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Index > Protein center > SFN(Gene name) > Human
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  • SFN (Gene name),
  • 14-3-3 protein sigma (Protein name ),  1433S_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SFN(HME1);
    Protein name:
    14-3-3 protein sigma;
    Alternative:
    Stratifin;Epithelial cell marker protein 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer. Interacts with KRT17 and SAMSN1 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with GAB2.
    Function:
    p53-regulated inhibitor of G2/M progression.
    Subcellular Location:
    Cytoplasm Nucleus Secreted May be secreted by a non-classical secretory pathway.
    Protein Attributes:
    Sequence length:
    248
    Sequence:
    50:
    MERASLIQKA | KLAEQAERYE | DMAAFMKGAV | EKGEELSCEE | RNLLSVAYKN | 
    100:
    VVGGQRAAWR | VLSSIEQKSN | EEGSEEKGPE | VREYREKVET | ELQGVCDTVL | 
    150:
    GLLDSHLIKE | AGDAESRVFY | LKMKGDYYRY | LAEVATGDDK | KRIIDSARSA | 
    200:
    YQEAMDISKK | EMPPTNPIRL | GLALNFSVFH | YEIANSPEEA | ISLAKTTFDE | 
    248:
    AMADLHTLSE | DSYKDSTLIM | QLLRDNLTLW | TADNAGEEGG | EAPQEPQS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    String:
    SMR:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human 14-3-3 protein sigma
    Cat.:
    E15106m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human 14-3-3 protein sigma
    Cat.:
    E15106h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human 14-3-3 protein sigma
    MSDS:
    Please sign in first.
    CLIA Kit for Human 14-3-3 protein sigma
    MSDS:
    Please sign in first.
    CLIA Kit for Human 14-3-3 protein sigma
    MSDS:
    Please sign in first.
    CLIA Kit for Human 14-3-3 protein sigma
    Cat.:
    U15106h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human 14-3-3 protein sigma
    Polyclonal Antibody for Human 14-3-3 protein sigma
    Polyclonal Antibody for Human 14-3-3 protein sigma
    Monoclonal Antibody for Human 14-3-3 protein sigma
    Monoclonal Antibody for Human 14-3-3 protein sigma
    Monoclonal Antibody for Human 14-3-3 protein sigma
    Protein for Human 14-3-3 protein sigma
    Protein for Human 14-3-3 protein sigma
    Protein for Human 14-3-3 protein sigma

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Complementary DNA cloning of a novel epithelial cell marker protein, HME1, that may be down-regulated in neoplastic mammary cells."
      Prasad G.L. , Valverius E.M. , McDuffie E. , Cooper H.L.
      Cell Growth Differ.3:507-513(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Epithelium.
    2. 2.
      "Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway."
      Leffers H. , Madsen P. , Rasmussen H.H. , Honore B. , Andersen A.H. , Walbum E. , Vandekerckhove J. , Celis J.E.
      J. Mol. Biol.231:982-998(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 19-25; 42-49; 118-122; 130-139; 149-159; 161-181; 196-199; 225-229 AND 231-239
      tissue: Keratinocyte.
    3. 3.
      "14-3-3 sigma is a p53-regulated inhibitor of G2/M progression."
      Hermeking H. , Lengauer C. , Polyak K. , He T.-C. , Zhang L. , Thiagalingam S. , Kinzler K.W. , Vogelstein B.
      Mol. Cell1:3-11(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
    4. 4.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    5. 5.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Cervix.
      tissue: Lung.
      tissue: Placenta.
    7. 7.
      "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
      Rasmussen H.H. , van Damme J. , Puype M. , Gesser B. , Celis J.E. , Vandekerckhove J.
      Electrophoresis13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 42-49 AND 118-122
      tissue: Keratinocyte.
    8. 8.
      "Exportin 7 defines a novel general nuclear export pathway."
      Mingot J.-M. , Bohnsack M.T. , Jaekle U. , Goerlich D.
      EMBO J.23:3227-3236(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH XPO7; ARHGAP1; EIF4A1; VPS26A; VPS29 AND VPS35
    9. 9.
      "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
      Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-248;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      "CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2."
      Yang W. , Dicker D.T. , Chen J. , El-Deiry W.S.
      Cell Cycle7:670-682(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MDM2 UBIQUITINATION;UBIQUITINATION BY RFFL
    11. 11.
      "Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein."
      Brummer T. , Larance M. , Herrera Abreu M.T. , Lyons R.J. , Timpson P. , Emmerich C.H. , Fleuren E.D.G. , Lehrbach G.M. , Schramek D. , Guilhaus M. , James D.E. , Daly R.J.
      EMBO J.27:2305-2316(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GAB2
    12. 12.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-248;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-248;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      "Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons."
      Jang S.W. , Liu X. , Fu H. , Rees H. , Yepes M. , Levey A. , Ye K.
      J. Biol. Chem.284:24512-24525(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SRPK2
    15. 15.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5 AND SER-248;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 17.
      "COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3sigma."
      Choi H.H. , Gully C. , Su C.H. , Velazquez-Torres G. , Chou P.C. , Tseng C. , Zhao R. , Phan L. , Shaiken T. , Chen J. , Yeung S.C. , Lee M.H.
      Oncogene30:4791-4801(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH COPS6 AND RFWD2
    18. 18.
      "A structural basis for 14-3-3sigma functional specificity."
      Wilker E.W. , Grant R.A. , Artim S.C. , Yaffe M.B.
      J. Biol. Chem.280:18891-18898(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) IN COMPLEX WITH PHOSPHOSERINE PEPTIDE
    19. 19.
      "Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI."
      Rose R. , Rose M. , Ottmann C.
      J. Struct. Biol.180:65-72(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 1-231 IN COMPLEX WITH PADI6 PHOSPHOPEPTIDES
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