Language:
  
[Sign in] [Register]   

EIAab logo

Index > Protein center > HLA-B27(Gene name) > Human
  • Add your favorite
  • HLA-B27 (Gene name),
  • HLA class I histocompatibility antigen, B-27 alpha chain (Protein name ),  1B27_HUMAN from NCBI database.
  • top
  • Come back to page head.
  • |
  • General Annotation
  • |
  • Antigen Annotation
  • |
  • 3D
  • |
  • Predicted Eptitope
  • |
  • Vaild Sequence
  • |
  • Related Databases
  • |
  • Feedback
  • Gene name:
    HLA-B(HLAB);
    Protein name:
    HLA class I histocompatibility antigen, B-27 alpha chain;
    Alternative:
    MHC class I antigen B*27;
    Organism:
    HLA-B27 (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein.
    Function:
    Involved in the presentation of foreign antigens to the immune system.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    362
    Sequence:
    50:
    mrvtaprtvl | lllsgalalt | etwagshsmr | yfytamsrpg | rgeprfisvg | 
    100:
    yvddtqfvrf | dsdaaspree | prapwieqeg | peywdrntqi | cktntqtyre | 
    150:
    slrnlrgyyn | qseagshtlq | rmygcdvgpd | grllrghdqy | aydgkdyial | 
    200:
    nedlsswtaa | dtaaqitqrk | weaareaeql | rayleglcve | wlrrylengk | 
    250:
    etlqradppk | thvthhpisd | heatlrcwal | gfypaeitlt | wqrdgedqtq | 
    300:
    dtelvetrpa | gdrtfqkwaa | vvvpsgeeqr | ytchvqhegl | pkpltlrwep | 
    350:
    ssqstipivg | ivaglavlav | vvigavvatv | mcrrkssggk | ggsysqaass | 
    362:
    dsaqgsdvsl | ta
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    SMR:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human HLA class I histocompatibility antigen, B-27 alpha chain
    Cat.:
    E1857h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human HLA class I histocompatibility antigen, B-27 alpha chain
    Cat.:
    U1857h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human HLA class I histocompatibility antigen, B-27 alpha chain
    Cat.:
    P1857Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human HLA class I histocompatibility antigen, B-27 alpha chain
    Protein for Human HLA class I histocompatibility antigen, B-27 alpha chain
    Cat.:
    R1857h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%

    R&D Technical Data

    12% SDS-PAGE analysis

             12% SDS-PAGE analysis

    wb1wb2

        Western blot - Anti-HLA-B27 antibody

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Organization, sequence and expression of the HLA-B27 gene: a molecular approach to analyze HLA and disease associations."
      Weiss E.H. , Kuon W. , Doerner C. , Lang M. , Riethmueller G.
      Immunobiology170:367-380(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*27:01)
    2. 2.
      "Complete sequence of HLA-B27 cDNA identified through the characterization of structural markers unique to the HLA-A, -B, and -C allelic series."
      Szoets H. , Riethmueller G. , Weiss E. , Meo T.
      Proc. Natl. Acad. Sci. U.S.A.83:1428-1432(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 25-361 (ALLELE B*27:01)
    3. 3.
      "Primary structure of papain-solubilized human histocompatibility antigen HLA-B27."
      Ezquerra A. , Bragado R. , Vega M.A. , Strominger J.L. , Woody J. , Lopez de Castro J.A.
      Biochemistry24:1733-1741(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-295 (B*27:01)
    4. 4.
      "Gene conversion-like mechanisms may generate polymorphism in human class I genes."
      Seemann G.H.A. , Rein R.S. , Brown C.S. , Ploegh H.L.
      EMBO J.5:547-552(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES B*27:01 AND B*27:02)
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*27:02)
    6. 6.
      "Structural analysis of an HLA-B27 functional variant: identification of residues that contribute to the specificity of recognition by cytolytic T lymphocytes."
      Vega M.A. , Ezquerra A. , Rojo S. , Aparicio P. , Bragado R. , Lopez de Castro J.A.
      Proc. Natl. Acad. Sci. U.S.A.82:7394-7398(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 86-107 AND 171-181 (B*27:02)
    7. 7.
      "Molecular analysis of the variant alloantigen HLA-B27d (HLA-B*2703) identifies a unique single amino acid substitution."
      Choo S.Y. , St John T. , Orr H.T. , Hansen J.A.
      Hum. Immunol.21:209-219(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*27:03)
    8. 8.
      "The nucleotide sequence of HLA-B*2704 reveals a new amino acid substitution in exon 4 which is also present in HLA-B*2706."
      Rudwaleit M. , Bowness P. , Wordsworth P.
      Immunogenetics43:160-162(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES B*27:04 AND B*27:06)
    9. 9.
      "Absence of polymorphism between HLA-B27 genomic exon sequences isolated from normal donors and ankylosing spondylitis patients."
      Coppin H.L. , McDevitt H.O.
      J. Immunol.137:2168-2172(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-298 (ALLELE B*27:05)
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*27:06)
    11. 11.
      "A novel HLA-B27 allele maps B27 allospecificity to the region around position 70 in the alpha 1 domain."
      Choo Y.S. , Fan L.A. , Hansen J.A.
      J. Immunol.147:174-180(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*27:07)
    12. 12.
      "The HLA-B7Qui antigen is encoded by a new subtype of HLA-B27 (B*2708)."
      Hildebrand W.H. , Domena J.D. , Shen S.Y. , Marsh S.G.E. , Bunce M. , Guttridge M.G. , Darke C. , Parham P.
      Tissue Antigens44:47-51(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*27:08)
    13. 13.
      "Identification of a novel HLA-B27 subtype by restriction analysis of a cytotoxic gamma/delta T cell clone."
      Del Porto P. , D'Amato M. , Fiorillo M.T. , Tuosto L. , Piccolella E. , Sorrentino R.
      J. Immunol.153:3093-3100(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*27:09)
      tissue: Blood.
    14. 14.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110
      tissue: Liver.
    15. 15.
      "The three-dimensional structure of HLA-B27 at 2.1-A resolution suggests a general mechanism for tight peptide binding to MHC."
      Madden D.R. , Gorga J.C. , Strominger J.L. , Wiley D.C.
      Cell70:1035-1048(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 25-300
    16. 16.
      "The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation."
      Madden D.R. , Gorga J.C. , Strominger J.L. , Wiley D.C.
      Nature353:321-325(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 25-300
    17. 17.
      "HLA-B27 subtypes differentially associated with disease exhibit subtle structural alterations."
      Hulsmeyer M. , Hillig R.C. , Volz A. , Ruhl M. , Schroder W. , Saenger W. , Ziegler A. , Uchanska-Ziegler B.
      J. Biol. Chem.277:47844-47853(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 25-300
    18. 18.
      "Rational design of nonnatural peptides as high-affinity ligands for the HLA-B*2705 human leukocyte antigen."
      Rognan D. , Scapozza L. , Folkers G. , Daser A.
      Proc. Natl. Acad. Sci. U.S.A.92:753-757(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING OF 115-206
    19. 19.
      "HLA-B27 in the Greek Cypriot population: distribution of subtypes in patients with ankylosing spondylitis and other HLA-B27-related diseases. The possible protective role of B*2707."
      Varnavidou-Nicolaidou A. , Karpasitou K. , Georgiou D. , Stylianou G. , Kokkofitou A. , Michalis C. , Constantina C. , Gregoriadou C. , Kyriakides G.
      Hum. Immunol.65:1451-1454(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE;POSSIBLE PROTECTIVE ROLE OF ALLELE B*27:07
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-65;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    Product Feedback Wall
    Hot Genes
    ALCAM ACE KSR2 ASPRO C19orf80 Gdf5 Trap1a Atf2
    Top Searches
    Ubiquitin ELISA Ubiquitin-protein ligase metalloproteinase Asprosin Tumor necrosis TRAP1A vitamin d
    Why choose EIAAB
    Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
    Further Information
    About us Protein center Bank account Distributors Terms & Conditions Career eiaab.cn

    Copyright & copy www.eiaab.com2006-2016 All Rights Reserved    EIAab         Email:eiaab@eiaab.com

    Twitter