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Index > Protein center > HLA-DRB1-15(Gene name) > Human
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  • HLA-DRB1-15 (Gene name),
  • HLA class II histocompatibility antigen, DRB1-15 beta chain (Protein name ),  2B1F_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    HLA-DRB1(HLA-DRB2);
    Protein name:
    HLA class II histocompatibility antigen, DRB1-15 beta chain;
    Alternative:
    MHC class II antigen DRB1*15;DW2.2/DR2.2;
    Organism:
    HLA-DRB1-15 (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms an heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B cells, in order to release CLIP and facilitate the binding of antigenic peptides.
    Function:
    Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accomodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form an heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein Endoplasmic reticulum membrane Single-pass type I membrane protein Golgi apparatus trans-Golgi network membrane Single-pass type I membrane protein Endosome membrane Single-pass type I membrane protein Lysosome membrane Single-pass type I membrane protein Late endosome membrane Single-pass type I membrane protein The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
    Protein Attributes:
    Sequence length:
    266
    Sequence:
    50:
    MVCLKLPGGS | CMTALTVTLM | VLSSPLALSG | DTRPRFLWQP | KRECHFFNGT | 
    100:
    ERVRFLDRYF | YNQEESVRFD | SDVGEFRAVT | ELGRPDAEYW | NSQKDILEQA | 
    150:
    RAAVDTYCRH | NYGVVESFTV | QRRVQPKVTV | YPSKTQPLQH | HNLLVCSVSG | 
    200:
    FYPGSIEVRW | FLNGQEEKAG | MVSTGLIQNG | DWTFQTLVML | ETVPRSGEVY | 
    250:
    TCQVEHPSVT | SPLTVEWRAR | SESAQSKMLS | GVGGFVLGLL | FLGAGLFIYF | 
    266:
    RNQKGHSGLQ | PTGFLS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    String:
    UniGene:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human HLA class II histocompatibility antigen, DRB1-15 beta chain
    Cat.:
    E9159h
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    MSDS:
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    Packing:
    96T
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    CLIA Kit for Human HLA class II histocompatibility antigen, DRB1-15 beta chain
    Cat.:
    U9159h
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    MSDS:
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    Packing:
    96T
    Range:
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    Polyclonal Antibody for Human HLA class II histocompatibility antigen, DRB1-15 beta chain
    Cat.:
    P9159Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human HLA class II histocompatibility antigen, DRB1-15 beta chain
    Protein for Human HLA class II histocompatibility antigen, DRB1-15 beta chain

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "MHC class II sequences of an HLA-DR2 narcoleptic."
      Lock C.B. , So A.K. , Welsh K.I. , Parkes J.D. , Trowsdale J.
      Immunogenetics27:449-455(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE DRB1*15:01)
      tissue: B-cell.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES DRB1*15:01; DRB1*15:02 AND DRB1*15:03)
    3. 3.
      "Group-specific amplification of cDNA from DRB1 genes. Complete coding sequences of partially defined alleles and identification of the new alleles DRB1*040602, DRB1*111102, DRB1*080103, and DRB1*0113."
      Balas A. , Vilches C. , Rodriguez M.A. , Fernandez B. , Martinez M.P. , de Pablo R. , Garcia-Sanchez F. , Vicario J.L.
      Hum. Immunol.67:1008-1016(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELES DRB1*15:03 AND DRB1*15:04)
      tissue: Blood.
    4. 4.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE DRB1*15:01)
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELES DRB1*15:01 AND DRB1*15:02)
      tissue: Leukocyte.
    6. 6.
      "cDNA cloning and sequencing reveals that the electrophoretically constant DR beta 2 molecules, as well as the variable DR beta 1 molecules, from HLA-DR2 subtypes have different amino acid sequences including a hypervariable region for a functionally important epitope."
      Wu S.K. , Yabe T. , Madden M. , Saunders T.L. , Bach F.H.
      J. Immunol.138:2953-2959(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-266 (ALLELE DRB1*15:02)
      tissue: Lymphoblast.
    7. 7.
      "HLA-DR2 subtypes form an additional supertypic family of DR beta alleles."
      Lee B.S.M. , Rust N.A. , McMichael A.J. , McDevitt H.O.
      Proc. Natl. Acad. Sci. U.S.A.84:4591-4595(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-266 (ALLELE DRB1*15:01)
      tissue: Lymphoblast.
    8. 8.
      "Allelic variation in the DR subregion of the human major histocompatibility complex."
      Bell J.I. , Denney D. Jr. , Foster L. , Belt T.K. , Todd J.A. , McDevitt H.O.
      Proc. Natl. Acad. Sci. U.S.A.84:6234-6238(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 30-266 (ALLELE DRB1*15:01)
      tissue: Lymphoblast.
    9. 9.
      "Primary structure of class II human histocompatibility antigens. 1st communication. Amino acid sequence of the N-terminal 198 residues of the beta chain of a HLA-Dw2,2;DR2,2-alloantigen."
      Kratzin H. , Yang C.-Y. , Gotz H. , Pauly E. , Kolbel S. , Egert G. , Thinnes F.P. , Wernet P. , Altevogt P. , Hilschmann N.
      Hoppe-Seyler's Z. Physiol. Chem.362:1665-1669(1981) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 30-228
      tissue: Lymphoblast.
    10. 10.
      "N-terminal amino acid sequences of the alpha and beta chains of HLA-DR1 and HLA-DR2 antigens."
      Walker L.E. , Hewick R. , Hunkapiller M.W. , Hood L.E. , Dreyer W.J. , Reisfeld R.A.
      Biochemistry22:185-188(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 30-64
      tissue: B-cell.
    11. 11.
      "Invariant chain structure and MHC class II function."
      Cresswell P.
      Cell84:505-507(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    12. 12.
      "Presentation of antigens by MHC class II molecules: getting the most out of them."
      Villadangos J.A.
      Mol. Immunol.38:329-346(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    13. 13.
      "Autophagy in MHC class II presentation: sampling from within."
      Menendez-Benito V. , Neefjes J.
      Immunity26:1-3(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    14. 14.
      "MHC class II molecules on the move for successful antigen presentation."
      Rocha N. , Neefjes J.
      EMBO J.27:1-5(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    15. 15.
      "MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation."
      De Gassart A. , Camosseto V. , Thibodeau J. , Ceppi M. , Catalan N. , Pierre P. , Gatti E.
      Proc. Natl. Acad. Sci. U.S.A.105:3491-3496(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY MARCH1;SUBCELLULAR LOCATION
    16. 16.
      "MHC class II transport at a glance."
      Berger A.C. , Roche P.A.
      J. Cell Sci.122:1-4(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    17. 17.
      "CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract."
      Beswick E.J. , Reyes V.E.
      World J. Gastroenterol.15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 19.
      "Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor."
      Hahn M. , Nicholson M.J. , Pyrdol J. , Wucherpfennig K.W.
      Nat. Immunol.6:490-496(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF 30-227
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