AADAT ELISA Kit for Human(Homo sapiens) | EIAab.comAADAT ELISA Kit for Human(Homo sapiens) | EIAab.com

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AADAT (Gene name),

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (Protein name ), AADAT_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

AADAT(KAT2);

Protein name:

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial(KAT/AadAT);

Alternative:

2.6.1.39;2-aminoadipate transaminase);2-aminoadipate aminotransferase;KAT/AadAT;Alpha-aminoadipate aminotransferase(AadAT);2.6.1.7;Kynurenine--oxoglutarate aminotransferase II);Kynurenine aminotransferase II;Kynurenine--oxoglutarate transaminase II;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer.

Function:

Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).

Subcellular Location:

Mitochondrion

Protein Attributes:

Sequence length:

425

Sequence:

50:

MNYARFITAA | SAARNPSPIR | TMTDILSRGP | KSMISLAGGL | PNPNMFPFKT |

100:

AVITVENGKT | IQFGEEMMKR | ALQYSPSAGI | PELLSWLKQL | QIKLHNPPTI |

150:

HYPPSQGQMD | LCVTSGSQQG | LCKVFEMIIN | PGDNVLLDEP | AYSGTLQSLH |

200:

PLGCNIINVA | SDESGIVPDS | LRDILSRWKP | EDAKNPQKNT | PKFLYTVPNG |

250:

NNPTGNSLTS | ERKKEIYELA | RKYDFLIIED | DPYYFLQFNK | FRVPTFLSMD |

300:

VDGRVIRADS | FSKIISSGLR | IGFLTGPKPL | IERVILHIQV | STLHPSTFNQ |

350:

LMISQLLHEW | GEEGFMAHVD | RVIDFYSNQK | DAILAAADKW | LTGLAEWHVP |

400:

AAGMFLWIKV | KGINDVKELI | EEKAVKMGVL | MLPGNAFYVD | SSAPSPYLRA |

425:

SFSSASPEQM | DVAFQVLAQL | IKESL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

String:

Pfam:

SMR:

MIM:

KEGG:

STRING:

9606.ENSP00000226840

Uniprot:

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ELISA Kit for Human KAT/AadAT

MSDS:

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ELISA Kit for Human KAT/AadAT

MSDS:

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ELISA Kit for Human KAT/AadAT

Cat.:

E12537r

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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ELISA Kit for Human KAT/AadAT

Cat.:

E12537m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human KAT/AadAT

Cat.:

U12537h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human KAT/AadAT

Cat.:

U12537r

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human KAT/AadAT

MSDS:

Please sign in first.

CLIA Kit for Human KAT/AadAT

Cat.:

U12537m

Price:

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MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human KAT/AadAT

Cat.:

P12537Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human KAT/AadAT

Polyclonal Antibody for Human KAT/AadAT

Polyclonal Antibody for Human KAT/AadAT

Monoclonal Antibody for Human KAT/AadAT

Monoclonal Antibody for Human KAT/AadAT

Monoclonal Antibody for Human KAT/AadAT

Monoclonal Antibody for Human KAT/AadAT

Protein for Human KAT/AadAT

Protein for Human KAT/AadAT

Protein for Human KAT/AadAT

Protein for Human KAT/AadAT

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

s

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s

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤5.7%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤8.2%

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Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤3.9%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.7%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Recovery

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Recovery was determined by spiking various levels of AADAT into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	97	94-103
Plasma	98	93-105

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Recovery was determined by spiking various levels of ACE into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	99	91-103
Plasma	98	93-106

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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The linearity of the kit was assayed by testing samples spiked with appropriate concentration of AADAT and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	93-101%	91-104%	95-100%	92-101%
EDTA plasma(n=5)	90-105%	95-103%	90-108%	94-102%
heparin plasma(n=5)	92-103%	93-102%	92-105%	91-106%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	92-105%	90-101%	95-105%	92-109%
EDTA plasma(n=5)	89-95%	93105%	89-94%	90-106%
heparin plasma(n=5)	93-104%	94-110%	101-111%	91-110%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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References

1.

"Cloning of human L-kynurenine/alpha-aminoadipate aminotransferase cDNA from brain tissue."
Gatti S. , Breton J. , Mostardini M. , Mosca M. , Tarroni P. , Schwarcz R. , Speciale C. , Okuno E. , Toma S. , Benatti L.
Submitted (1998-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
2.

"Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT)."
Goh D.L.M. , Patel A. , Thomas G.H. , Salomons G.S. , Schor D.S.M. , Jakobs C. , Geraghty M.T.
Mol. Genet. Metab.76:172-180(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CATALYTIC ACTIVITY;COFACTOR
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Brain.
5.

"Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II."
Han Q. , Cai T. , Tagle D.A. , Robinson H. , Li J.
Biosci. Rep.28:205-215(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH 2-OXOGLUTARATE;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES;ENZYME REGULATION;SUBUNIT;FUNCTION
6.

"Crystal structure of human kynurenine aminotransferase II."
Han Q. , Robinson H. , Li J.
J. Biol. Chem.283:3567-3573(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) IN COMPLEX WITH PYRIDOXAL PHOSPHATE AND KYRUNENINE;CATALYTIC ACTIVITY;COFACTOR;SUBUNIT
7.

"Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia."
Rossi F. , Garavaglia S. , Montalbano V. , Walsh M.A. , Rizzi M.
J. Biol. Chem.283:3559-3566(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) IN COMPLEX WITH PYRIDOXAL PHOSPHATE;SUBUNIT;COFACTOR

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