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Index > Protein center > AADAT(Gene name) > Human
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  • AADAT (Gene name),
  • Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (Protein name ),  AADAT_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    AADAT(KAT2);
    Protein name:
    Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial(KAT/AadAT);
    Alternative:
    2.6.1.7;Kynurenine--oxoglutarate aminotransferase II);Kynurenine aminotransferase II;KAT/AadAT;Alpha-aminoadipate aminotransferase(AadAT);Kynurenine--oxoglutarate transaminase II;2-aminoadipate aminotransferase;2.6.1.39;2-aminoadipate transaminase);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).
    Subcellular Location:
    Mitochondrion
    Protein Attributes:
    Sequence length:
    425
    Sequence:
    50:
    MNYARFITAA | SAARNPSPIR | TMTDILSRGP | KSMISLAGGL | PNPNMFPFKT | 
    100:
    AVITVENGKT | IQFGEEMMKR | ALQYSPSAGI | PELLSWLKQL | QIKLHNPPTI | 
    150:
    HYPPSQGQMD | LCVTSGSQQG | LCKVFEMIIN | PGDNVLLDEP | AYSGTLQSLH | 
    200:
    PLGCNIINVA | SDESGIVPDS | LRDILSRWKP | EDAKNPQKNT | PKFLYTVPNG | 
    250:
    NNPTGNSLTS | ERKKEIYELA | RKYDFLIIED | DPYYFLQFNK | FRVPTFLSMD | 
    300:
    VDGRVIRADS | FSKIISSGLR | IGFLTGPKPL | IERVILHIQV | STLHPSTFNQ | 
    350:
    LMISQLLHEW | GEEGFMAHVD | RVIDFYSNQK | DAILAAADKW | LTGLAEWHVP | 
    400:
    AAGMFLWIKV | KGINDVKELI | EEKAVKMGVL | MLPGNAFYVD | SSAPSPYLRA | 
    425:
    SFSSASPEQM | DVAFQVLAQL | IKESL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    SMR:
    UniGene:
    String:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human KAT/AadAT
    MSDS:
    Please sign in first.
    ELISA Kit for Human KAT/AadAT
    MSDS:
    Please sign in first.
    ELISA Kit for Human KAT/AadAT
    Cat.:
    E12537m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human KAT/AadAT
    Cat.:
    E12537r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human KAT/AadAT
    Cat.:
    U12537r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human KAT/AadAT
    Cat.:
    U12537m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human KAT/AadAT
    Cat.:
    U12537h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human KAT/AadAT
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Human KAT/AadAT
    Polyclonal Antibody for Human KAT/AadAT
    Polyclonal Antibody for Human KAT/AadAT
    Cat.:
    P12537Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human KAT/AadAT
    Monoclonal Antibody for Human KAT/AadAT
    Monoclonal Antibody for Human KAT/AadAT
    Monoclonal Antibody for Human KAT/AadAT
    Monoclonal Antibody for Human KAT/AadAT
    Protein for Human KAT/AadAT
    Protein for Human KAT/AadAT
    Protein for Human KAT/AadAT
    Protein for Human KAT/AadAT

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    s

    s
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤5.7%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤8.2%

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤3.9%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.7%

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    Recovery was determined by spiking various levels of AADAT into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    97

    94-103

    Plasma

    98

    93-105

     

     

     

     

    Recovery was determined by spiking various levels of ACE into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    99

    91-103

    Plasma

    98

    93-106

     

     

     

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of AADAT and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    93-101%

    91-104%

    95-100%

    92-101%

    EDTA plasma(n=5)

    90-105%

    95-103%

    90-108%

    94-102%

    heparin plasma(n=5)

    92-103%

     

    93-102%

    92-105%

    91-106%

     

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    92-105%

    90-101%

    95-105%

    92-109%

    EDTA plasma(n=5)

    89-95%

    93105%

    89-94%

    90-106%

    heparin plasma(n=5)

    93-104%

     

    94-110%

    101-111%

    91-110%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Cloning of human L-kynurenine/alpha-aminoadipate aminotransferase cDNA from brain tissue."
      Gatti S. , Breton J. , Mostardini M. , Mosca M. , Tarroni P. , Schwarcz R. , Speciale C. , Okuno E. , Toma S. , Benatti L.
      Submitted (1998-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    2. 2.
      "Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT)."
      Goh D.L.M. , Patel A. , Thomas G.H. , Salomons G.S. , Schor D.S.M. , Jakobs C. , Geraghty M.T.
      Mol. Genet. Metab.76:172-180(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CATALYTIC ACTIVITY;COFACTOR
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
    5. 5.
      "Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II."
      Han Q. , Cai T. , Tagle D.A. , Robinson H. , Li J.
      Biosci. Rep.28:205-215(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH 2-OXOGLUTARATE;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES;ENZYME REGULATION;SUBUNIT;FUNCTION
    6. 6.
      "Crystal structure of human kynurenine aminotransferase II."
      Han Q. , Robinson H. , Li J.
      J. Biol. Chem.283:3567-3573(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) IN COMPLEX WITH PYRIDOXAL PHOSPHATE AND KYRUNENINE;CATALYTIC ACTIVITY;COFACTOR;SUBUNIT
    7. 7.
      "Crystal structure of human kynurenine aminotransferase II, a drug target for the treatment of schizophrenia."
      Rossi F. , Garavaglia S. , Montalbano V. , Walsh M.A. , Rizzi M.
      J. Biol. Chem.283:3559-3566(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) IN COMPLEX WITH PYRIDOXAL PHOSPHATE;SUBUNIT;COFACTOR
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