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Index > Protein center > ACLY(Gene name) > Human
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  • ACLY (Gene name),
  • ATP-citrate synthase (Protein name ),  ACLY_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ACLY;
    Protein name:
    ATP-citrate synthase;
    Alternative:
    ATP-citrate (pro-S-)-lyase(ACL);Citrate cleavage enzyme;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotetramer.
    Function:
    ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    1101
    Sequence:
    50:
    MSAKAISEQT | GKELLYKFIC | TTSAIQNRFK | YARVTPDTDW | ARLLQDHPWL | 
    100:
    LSQNLVVKPD | QLIKRRGKLG | LVGVNLTLDG | VKSWLKPRLG | QEATVGKATG | 
    150:
    FLKNFLIEPF | VPHSQAEEFY | VCIYATREGD | YVLFHHEGGV | DVGDVDAKAQ | 
    200:
    KLLVGVDEKL | NPEDIKKHLL | VHAPEDKKEI | LASFISGLFN | FYEDLYFTYL | 
    250:
    EINPLVVTKD | GVYVLDLAAK | VDATADYICK | VKWGDIEFPP | PFGREAYPEE | 
    300:
    AYIADLDAKS | GASLKLTLLN | PKGRIWTMVA | GGGASVVYSD | TICDLGGVNE | 
    350:
    LANYGEYSGA | PSEQQTYDYA | KTILSLMTRE | KHPDGKILII | GGSIANFTNV | 
    400:
    AATFKGIVRA | IRDYQGPLKE | HEVTIFVRRG | GPNYQEGLRV | MGEVGKTTGI | 
    450:
    PIHVFGTETH | MTAIVGMALG | HRPIPNQPPT | AAHTANFLLN | ASGSTSTPAP | 
    500:
    SRTASFSESR | ADEVAPAKKA | KPAMPQDSVP | SPRSLQGKST | TLFSRHTKAI | 
    550:
    VWGMQTRAVQ | GMLDFDYVCS | RDEPSVAAMV | YPFTGDHKQK | FYWGHKEILI | 
    600:
    PVFKNMADAM | RKHPEVDVLI | NFASLRSAYD | STMETMNYAQ | IRTIAIIAEG | 
    650:
    IPEALTRKLI | KKADQKGVTI | IGPATVGGIK | PGCFKIGNTG | GMLDNILASK | 
    700:
    LYRPGSVAYV | SRSGGMSNEL | NNIISRTTDG | VYEGVAIGGD | RYPGSTFMDH | 
    750:
    VLRYQDTPGV | KMIVVLGEIG | GTEEYKICRG | IKEGRLTKPI | VCWCIGTCAT | 
    800:
    MFSSEVQFGH | AGACANQASE | TAVAKNQALK | EAGVFVPRSF | DELGEIIQSV | 
    850:
    YEDLVANGVI | VPAQEVPPPT | VPMDYSWARE | LGLIRKPASF | MTSICDERGQ | 
    900:
    ELIYAGMPIT | EVFKEEMGIG | GVLGLLWFQK | RLPKYSCQFI | EMCLMVTADH | 
    950:
    GPAVSGAHNT | IICARAGKDL | VSSLTSGLLT | IGDRFGGALD | AAAKMFSKAF | 
    1000:
    DSGIIPMEFV | NKMKKEGKLI | MGIGHRVKSI | NNPDMRVQIL | KDYVRQHFPA | 
    1050:
    TPLLDYALEV | EKITTSKKPN | LILNVDGLIG | VAFVDMLRNC | GSFTREEADE | 
    1100:
    YIDIGALNGI | FVLGRSMGFI | GHYLDQKRLK | QGLYRHPWDD | ISYVLPEHMS | 
    1101:
    M
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    MIM:
    Pfam:
    SMR:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human ATP-citrate synthase
    Cat.:
    E14203h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human ATP-citrate synthase
    Cat.:
    E14203m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human ATP-citrate synthase
    Cat.:
    E14203r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human ATP-citrate synthase
    MSDS:
    Please sign in first.
    CLIA Kit for Human ATP-citrate synthase
    MSDS:
    Please sign in first.
    CLIA Kit for Human ATP-citrate synthase
    Cat.:
    U14203h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human ATP-citrate synthase
    Cat.:
    U14203m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human ATP-citrate synthase
    Cat.:
    U14203r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human ATP-citrate synthase
    Polyclonal Antibody for Human ATP-citrate synthase
    Polyclonal Antibody for Human ATP-citrate synthase
    Polyclonal Antibody for Human ATP-citrate synthase
    Monoclonal Antibody for Human ATP-citrate synthase
    Monoclonal Antibody for Human ATP-citrate synthase
    Monoclonal Antibody for Human ATP-citrate synthase
    Monoclonal Antibody for Human ATP-citrate synthase
    Protein for Human ATP-citrate synthase
    Protein for Human ATP-citrate synthase
    Protein for Human ATP-citrate synthase
    Protein for Human ATP-citrate synthase

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ASP-175
      tissue: Liver.
    2. 2.
      "Variant cDNA sequences of human ATP:citrate lyase: cloning, expression, and purification from baculovirus-infected insect cells."
      Lord K.A. , Wang X.M. , Simmons S.J. , Bruckner R.C. , Loscig J. , O'Connor B. , Bentley R. , Smallwood A. , Chadwick C.C. , Stevis P.E. , Ciccarelli R.B.
      Protein Expr. Purif.9:133-141(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ASP-175
      tissue: Liver.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3);VARIANT ASP-175
      tissue: Hippocampus.
      tissue: Uterus.
    4. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lymph.
    5. 6.
      "Phosphorylation of recombinant human ATP:citrate lyase by cAMP-dependent protein kinase abolishes homotropic allosteric regulation of the enzyme by citrate and increases the enzyme activity. Allosteric activation of ATP:citrate lyase by phosphorylated sugars."
      Potapova I.A. , El-Maghrabi M.R. , Doronin S.V. , Benjamin W.B.
      Biochemistry39:1169-1179(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;PHOSPHORYLATION
    6. 7.
      "Proteomic identification of proteins conjugated to ISG15 in mouse and human cells."
      Giannakopoulos N.V. , Luo J.K. , Papov V. , Zou W. , Lenschow D.J. , Jacobs B.S. , Borden E.C. , Li J. , Virgin H.W. , Zhang D.E.
      Biochem. Biophys. Res. Commun.336:496-506(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ISGYLATION
    7. 8.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
      Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-131 AND TYR-682;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    8. 9.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 10.
      "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
      Yu L.R. , Zhu Z. , Chan K.C. , Issaq H.J. , Dimitrov D.S. , Veenstra T.D.
      J. Proteome Res.6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Platelet.
    11. 12.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-455; SER-481 AND SER-1100;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 14.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481; THR-639; SER-663; TYR-682; SER-839 AND SER-1100;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 16.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-481;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    16. 17.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-546; LYS-554; LYS-948; LYS-968 AND LYS-1077;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 18.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-455 AND SER-481;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    18. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 20.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-455 AND SER-481;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 21.
      "Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth."
      Lin R. , Tao R. , Gao X. , Li T. , Zhou X. , Guan K.L. , Xiong Y. , Lei Q.Y.
      Mol. Cell51:506-518(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ACETYLATION AT LYS-540; LYS-546 AND LYS-554;UBIQUITINATION AT LYS-540; LYS-546 AND LYS-554;MUTAGENESIS OF LYS-540; LYS-546 AND LYS-554
    21. 22.
      "Identification of the citrate-binding site of human ATP-citrate lyase using X-ray crystallography."
      Sun T. , Hayakawa K. , Bateman K.S. , Fraser M.E.
      J. Biol. Chem.285:27418-27428(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 1-425 AND 487-820 IN COMPLEX WITH CITRATE;CITRATE-BINDING SITES
    22. 23.
      "ADP-Mg2+ bound to the ATP-grasp domain of ATP-citrate lyase."
      Sun T. , Hayakawa K. , Fraser M.E.
      Acta Crystallogr. F67:1168-1172(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1-817 IN COMPLEX WITH ADP
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