ACTN4 ELISA Kit for Human(Homo sapiens) | EIAab.comACTN4 ELISA Kit for Human(Homo sapiens)

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ACTN4 (Gene name),

Alpha-actinin-4 (Protein name ), ACTN4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ACTN4;

Protein name:

Alpha-actinin-4;

Alternative:

Non-muscle alpha-actinin 4;F-actin cross-linking protein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer; antiparallel (By similarity). Binds TRIM3 at the N-terminus (By similarity). Identified in a complex with CASK, IQGAP1, MAGI2, NPHS1, SPTAN1 and SPTBN1 (By similarity). Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3. Interacts with BAIAP1 and PDLIM2.

Function:

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation.

Subcellular Location:

Nucleus Cytoplasm Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Colocalizes with actin stress fibers. Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines.

Protein Attributes:

Sequence length:

911

Sequence:

50:

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350:

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650:

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850:

900:

911:

FSTALYGESD | L

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.270291

KEGG:

hsa:81

Pfam:

PF00307

String:

O43707

STRING:

9606.ENSP00000252699

SMR:

O43707

MIM:

603278

Uniprot:

O43707

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ELISA Kit for Human Alpha-actinin-4

Cat.:

E1460h

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Manual:

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96T

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ELISA Kit for Human Alpha-actinin-4

Cat.:

E1460c

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96T

ELISA Kit for Human Alpha-actinin-4

Cat.:

E1460r

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96T

ELISA Kit for Human Alpha-actinin-4

Cat.:

E1460m

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96T

ELISA Kit for Human Alpha-actinin-4

Cat.:

E1460b

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96T

CLIA Kit for Human Alpha-actinin-4

Cat.:

U1460m

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96T

CLIA Kit for Human Alpha-actinin-4

Cat.:

U1460h

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Packing:

96T

CLIA Kit for Human Alpha-actinin-4

Cat.:

U1460r

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Packing:

96T

CLIA Kit for Human Alpha-actinin-4

Cat.:

U1460c

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Packing:

96T

CLIA Kit for Human Alpha-actinin-4

Cat.:

U1460b

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Packing:

96T

Polyclonal Antibody for Human Alpha-actinin-4

Cat.:

P1460Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Alpha-actinin-4

Cat.:

P1460Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Alpha-actinin-4

Cat.:

P1460Rb-m

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40ug/0.2ml

Monoclonal Antibody for Human Alpha-actinin-4

Protein for Human Alpha-actinin-4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion."
Honda K. , Yamada T. , Endo R. , Ino Y. , Gotoh M. , Tsuda H. , Yamada Y. , Chiba H. , Hirohashi S.
J. Cell Biol.140:1383-1393(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-911 (ISOFORM 1)
2.

Honda K. , Yamada T. , Endo R. , Ino Y. , Gotoh M. , Tsuda H. , Yamada Y. , Chiba H. , Hirohashi S.
J. Cell Biol.143:276-276(1998)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
3.

"The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells."
Nikolopoulos S.N. , Spengler B.A. , Kisselbach K. , Evans A.E. , Biedler J.L. , Ross R.A.
Oncogene19:380-386(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Neuroblastoma.
4.

"Novel splicing isoform of actin-binding protein alpha-actinin 4 in epidermoid carcinoma cells A431."
Aksenova V.I.U. , Khotin M.G. , Turoverova L.V. , Iudintseva N.M. , Magnusson K.E. , Pinaev G.P. , Tentler D.G.
Tsitologiia54:25-32(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ACTN4ISO);SUBCELLULAR LOCATION;ALTERNATIVE SPLICING
5.

"Actinin alpha4, an actin binding protein, is a transcriptional coactivator that antagonizes class II HDAC activity."
Chakraborty S. , Cheng X. , Lam M. , Reineke E.L. , Li X. , Liu Y. , Gao C. , Khurana S. , Kao H.-Y.
Submitted (2006-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
6.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Placenta.
8.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-170 (ISOFORM 1)
tissue: Uterus.
9.

"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes."
Kimura K. , Wakamatsu A. , Suzuki Y. , Ota T. , Nishikawa T. , Yamashita R. , Yamamoto J. , Sekine M. , Tsuritani K. , Wakaguri H. , Ishii S. , Sugiyama T. , Saito K. , Isono Y. , Irie R. , Kushida N. , Yoneyama T. , Otsuka R. , more...
Genome Res.16:55-65(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-218 (ISOFORM 1)
10.

"Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1."
Patrie K.M. , Drescher A.J. , Welihinda A. , Mundel P. , Margolis B.
J. Biol. Chem.277:30183-30190(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BAIAP1
11.

"CART: an Hrs/actinin-4/BERP/myosin V protein complex required for efficient receptor recycling."
Yan Q. , Sun W. , Kujala P. , Lotfi Y. , Vida T.A. , Bean A.J.
Mol. Biol. Cell16:2470-2482(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE CART COMPLEX
12.

"Molecular composition of IMP1 ribonucleoprotein granules."
Joeson L. , Vikesaa J. , Krogh A. , Nielsen L.K. , Hansen T. , Borup R. , Johnsen A.H. , Christiansen J. , Nielsen F.C.
Mol. Cell. Proteomics6:798-811(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A MRNP GRANULE COMPLEX;IDENTIFICATION BY MASS SPECTROMETRY;SUBCELLULAR LOCATION
13.

"Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
Denis N.J. , Vasilescu J. , Lambert J.-P. , Smith J.C. , Figeys D.
Proteomics7:868-874(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-378
tissue: Mammary cancer.
14.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-114; LYS-592 AND LYS-625;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.

"Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis."
Kaplan J.M. , Kim S.H. , North K.N. , Rennke H. , Correia L.A. , Tong H.-Q. , Mathis B.J. , Rodriguez-Perez J.-C. , Allen P.G. , Beggs A.H. , Pollak M.R.
Nat. Genet.24:251-256(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FSGS1 GLU-255; ILE-259 AND PRO-262
tissue: Lymphocyte.

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