ACTA1 ELISA Kit for Human(Homo sapiens) | EIAab.comACTA1 ELISA Kit for Human(Homo sapiens)

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ACTA1 (Gene name),

Actin, alpha skeletal muscle (Protein name ), ACTS_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ACTA1(ACTA);

Protein name:

Actin, alpha skeletal muscle;

Alternative:

Alpha-actin-1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Interacts with TTID. Interacts (via its C-terminus) with USP25; the interaction occurs for all USP25 isoforms but is strongest for isoform USP25m in muscle differentiating cells.

Function:

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Subcellular Location:

Cytoplasm cytoskeleton

Protein Attributes:

Sequence length:

377

Sequence:

50:

100:

150:

200:

250:

300:

350:

377:

LSTFQQMWIT | KQEYDEAGPS | IVHRKCF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.1288

STRING:

9606.ENSP00000355645

String:

P68133

Pfam:

PF00022

SMR:

P68133

MIM:

102610

KEGG:

hsa:58

Uniprot:

P68133

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ELISA Kit for Human Actin, alpha skeletal muscle

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E1634h

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96T

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ELISA Kit for Human Actin, alpha skeletal muscle

Cat.:

E1634b

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96T

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ELISA Kit for Human Actin, alpha skeletal muscle

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ELISA Kit for Human Actin, alpha skeletal muscle

Cat.:

E1634r

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Packing:

96T

ELISA Kit for Human Actin, alpha skeletal muscle

Cat.:

E1634m

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96T

ELISA Kit for Human Actin, alpha skeletal muscle

Cat.:

E1634p

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96T

ELISA Kit for Human Actin, alpha skeletal muscle

Cat.:

E1634c

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96T

CLIA Kit for Human Actin, alpha skeletal muscle

Cat.:

U1634c

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96T

CLIA Kit for Human Actin, alpha skeletal muscle

Cat.:

U1634r

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Packing:

96T

CLIA Kit for Human Actin, alpha skeletal muscle

Cat.:

U1634h

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Actin, alpha skeletal muscle

Cat.:

U1634b

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MSDS:

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Packing:

96T

CLIA Kit for Human Actin, alpha skeletal muscle

Cat.:

U1634p

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Actin, alpha skeletal muscle

Cat.:

U1634m

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96T

CLIA Kit for Human Actin, alpha skeletal muscle

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Polyclonal Antibody for Human Actin, alpha skeletal muscle

Cat.:

P1634Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Actin, alpha skeletal muscle

Cat.:

P1634Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Actin, alpha skeletal muscle

Cat.:

P1634Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Actin, alpha skeletal muscle

Monoclonal Antibody for Human Actin, alpha skeletal muscle

Protein for Human Actin, alpha skeletal muscle

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Isolation and characterization of cDNA clones for human skeletal muscle alpha actin."
Hanauer A. , Levin M. , Heilig R. , Daegelen D. , Kahn A. , Mandel J.-L.
Nucleic Acids Res.11:3503-3516(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Skeletal muscle.
2.

"Nucleotide sequence and expression of the human skeletal alpha-actin gene: evolution of functional regulatory domains."
Taylor A. , Erba H.P. , Muscat G.E.O. , Kedes L.
Genomics3:323-336(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Mutations in the skeletal muscle alpha-actin gene in patients with actin myopathy and nemaline myopathy."
Nowak K.J. , Wattanasirichaigoon D. , Goebel H.H. , Wilce M. , Pelin K. , Donner K. , Jacob R.L. , Hubner C. , Oexle K. , Anderson J.R. , Verity C.M. , North K.N.
Nat. Genet.23:208-212(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS NEM3 TYR-42; PRO-96; SER-117; VAL-134; ASP-184; CYS-185; HIS-258; VAL-261; LEU-265; LYS-282; GLY-288 AND PHE-372;VARIANTS MPCETM ARG-17 AND LEU-165
4.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Skeletal muscle.
8.

"Myotilin is mutated in limb girdle muscular dystrophy 1A."
Hauser M.A. , Horrigan S.K. , Salmikangas P. , Torian U.M. , Viles K.D. , Dancel R. , Tim R.W. , Taivainen A. , Bartoloni L. , Gilchrist J.M. , Stajich J.M. , Gaskell P.C. , Gilbert J.R. , Vance J.M. , Pericak-Vance M.A. , Carpen O. , Westbrook C.A. , Speer M.C.
Hum. Mol. Genet.9:2141-2147(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TTID
9.

"The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins."
Bosch-Comas A. , Lindsten K. , Gonzalez-Duarte R. , Masucci M.G. , Marfany G.
Cell. Mol. Life Sci.63:723-734(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH USP25
10.

"The first identification of lysine malonylation substrates and its regulatory enzyme."
Peng C. , Lu Z. , Xie Z. , Cheng Z. , Chen Y. , Tan M. , Luo H. , Zhang Y. , He W. , Yang K. , Zwaans B.M. , Tishkoff D. , Ho L. , Lombard D. , He T.C. , Dai J. , Verdin E. , Ye Y. , more...
Mol. Cell. Proteomics10:M111.012658.01-M111.012658.12(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MALONYLATION AT LYS-63
11.

"ALKBH4-dependent demethylation of actin regulates actomyosin dynamics."
Li M.M. , Nilsen A. , Shi Y. , Fusser M. , Ding Y.H. , Fu Y. , Liu B. , Niu Y. , Wu Y.S. , Huang C.M. , Olofsson M. , Jin K.X. , Lv Y. , Xu X.Z. , He C. , Dong M.Q. , Rendtlew Danielsen J.M. , Klungland A. , more...
Nat. Commun.4:1832-1832(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: METHYLATION AT LYS-86;DEMETHYLATION BY ALKBH4
12.

"Nemaline myopathy caused by mutations in the muscle alpha-skeletal-actin gene."
Ilkovski B. , Cooper S.T. , Nowak K. , Ryan M.M. , Yang N. , Schnell C. , Durling H.J. , Roddick L.G. , Wilkinson I. , Kornberg A.J. , Collins K.J. , Wallace G. , Gunning P. , Hardeman E.C. , Laing N.G. , North K.N.
Am. J. Hum. Genet.68:1333-1343(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS NEM3 SER-117; MET-138; GLY-185; CYS-270 AND LEU-359
13.

"Muscle disease caused by mutations in the skeletal muscle alpha-actin gene (ACTA1)."
Sparrow J.C. , Nowak K.J. , Durling H.J. , Beggs A.H. , Wallgren-Pettersson C. , Romero N. , Nonaka I. , Laing N.G.
Neuromuscul. Disord.13:519-531(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON VARIANTS
14.

"Mild phenotype of nemaline myopathy with sleep hypoventilation due to a mutation in the skeletal muscle alpha-actin (ACTA1) gene."
Jungbluth H. , Sewry C.A. , Brown S.C. , Nowak K.J. , Laing N.G. , Wallgren-Pettersson C. , Pelin K. , Manzur A.Y. , Mercuri E. , Dubowitz V. , Muntoni F.
Neuromuscul. Disord.11:35-40(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS NEM3 VAL-134 AND ARG-271
15.

"Heterogeneity of nemaline myopathy cases with skeletal muscle alpha-actin gene mutations."
Agrawal P.B. , Strickland C.D. , Midgett C. , Morales A. , Newburger D.E. , Poulos M.A. , Tomczak K.K. , Ryan M.M. , Iannaccone S.T. , Crawford T.O. , Laing N.G. , Beggs A.H.
Ann. Neurol.56:86-96(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS NEM3 LEU-37; LEU-40; TYR-42; ARG-43; ASN-66; LEU-75; ARG-75; LEU-77; ALA-79; LYS-85; ALA-136; ASP-148; GLY-181; ASP-184; GLY-185; SER-199; GLY-226; VAL-229; ILE-229; ARG-248; ASP-253; CYS-270; HIS-281; LYS-282; GLY-288 AND GLN-375
16.

"Actin mutations are one cause of congenital fibre type disproportion."
Laing N.G. , Clarke N.F. , Dye D.E. , Liyanage K. , Walker K.R. , Kobayashi Y. , Shimakawa S. , Hagiwara T. , Ouvrier R. , Sparrow J.C. , Nishino I. , North K.N. , Nonaka I.
Ann. Neurol.56:689-694(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CFTD PRO-223; VAL-294 AND SER-334
17.

"Evidence for a dominant-negative effect in ACTA1 nemaline myopathy caused by abnormal folding, aggregation and altered polymerization of mutant actin isoforms."
Ilkovski B. , Nowak K.J. , Domazetovska A. , Maxwell A.L. , Clement S. , Davies K.E. , Laing N.G. , North K.N. , Cooper S.T.
Hum. Mol. Genet.13:1727-1743(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS NEM3 ILE-68; LYS-74; SER-117; MET-138; LEU-165; MET-165; GLY-185; CYS-270 AND LEU-359
18.

"Missense mutations of ACTA1 cause dominant congenital myopathy with cores."
Kaindl A.M. , Rueschendorf F. , Krause S. , Goebel H.-H. , Koehler K. , Becker C. , Pongratz D. , Mueller-Hoecker J. , Nuernberg P. , Stoltenburg-Didinger G. , Lochmueller H. , Huebner A.
J. Med. Genet.41:842-848(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS NEM3 TYR-3 AND ALA-336
19.

"Follow-up of nemaline myopathy in two patients with novel mutations in the skeletal muscle alpha-actin gene (ACTA1)."
Ohlsson M. , Tajsharghi H. , Darin N. , Kyllerman M. , Oldfors A.
Neuromuscul. Disord.14:471-475(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS NEM3 ASP-270 AND GLU-375
20.

"Autosomal dominant nemaline myopathy with intranuclear rods due to mutation of the skeletal muscle ACTA1 gene: clinical and pathological variability within a kindred."
Hutchinson D.O. , Charlton A. , Laing N.G. , Ilkovski B. , North K.N.
Neuromuscul. Disord.16:113-121(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT NEM3 MET-165
21.

"Fatal hypertrophic cardiomyopathy and nemaline myopathy associated with ACTA1 K336E mutation."
D'Amico A. , Graziano C. , Pacileo G. , Petrini S. , Nowak K.J. , Boldrini R. , Jacques A. , Feng J.-J. , Porfirio B. , Sewry C.A. , Santorelli F.M. , Limongelli G. , Bertini E. , Laing N. , Marston S.B.
Neuromuscul. Disord.16:548-552(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT NEM3 GLU-338
22.

"The pathogenesis of ACTA1-related congenital fiber type disproportion."
Clarke N.F. , Ilkovski B. , Cooper S. , Valova V.A. , Robinson P.J. , Nonaka I. , Feng J.-J. , Marston S. , North K.
Ann. Neurol.61:552-561(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT CFTD VAL-294
23.

"Intranuclear rod myopathy: molecular pathogenesis and mechanisms of weakness."
Domazetovska A. , Ilkovski B. , Kumar V. , Valova V.A. , Vandebrouck A. , Hutchinson D.O. , Robinson P.J. , Cooper S.T. , Sparrow J.C. , Peckham M. , North K.N.
Ann. Neurol.62:597-608(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT NEM3 MET-165

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