ADAM10 ELISA Kit for Bovine(Bos taurus) | EIAab.comADAM10 ELISA Kit for Bovine(Bos taurus)

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ADAM10 (Gene name),

Disintegrin and metalloproteinase domain-containing protein 10 (Protein name ), ADA10_BOVIN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ADAM10(MADM);

Protein name:

Disintegrin and metalloproteinase domain-containing protein 10(ADAM 10);

Alternative:

Mammalian disintegrin-metalloprotease;Kuzbanian protein homolog;Myelin-associated metalloproteinase;

CD:

CD156c;

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function. Interacts with EPHA2.

Function:

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch. May regulate the EFNA5-EPHA3 signaling.

Subcellular Location:

Golgi apparatus membrane Single-pass type I membrane protein Cell membrane Single-pass type I membrane protein The protealytically actived form is localized mainly in the plasma membrane whereas the proenzyme is found intracellularly in the Golgi.

Protein Attributes:

Sequence length:

748

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

748:

VHTPSSNPKL | PPPKPLPGTL | KRRRPPQPIQ | QPQRQRPRES | YQMGHMRR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q10741

KEGG:

bta:282132

SMR:

Q10741

Pfam:

PF00200

UniGene:

Bt.49218

Uniprot:

Q10741

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ELISA Kit for Bovine ADAM 10

Cat.:

E0766h

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96T

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ELISA Kit for Bovine ADAM 10

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ELISA Kit for Bovine ADAM 10

Cat.:

E0766m

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Packing:

96T

ELISA Kit for Bovine ADAM 10

Cat.:

E0766b

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96T

ELISA Kit for Bovine ADAM 10

Cat.:

E0766r

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Packing:

96T

CLIA Kit for Bovine ADAM 10

Cat.:

U0766m

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MSDS:

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Packing:

96T

CLIA Kit for Bovine ADAM 10

MSDS:

Please sign in first.

CLIA Kit for Bovine ADAM 10

Cat.:

U0766h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

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CLIA Kit for Bovine ADAM 10

Cat.:

U0766b

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MSDS:

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Packing:

96T

CLIA Kit for Bovine ADAM 10

Cat.:

U0766r

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96T

Polyclonal Antibody for Bovine ADAM 10

Cat.:

P0766Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Bovine ADAM 10

Cat.:

P0766Rb-m

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40ug/0.2ml

Polyclonal Antibody for Bovine ADAM 10

Cat.:

P0766Rb-r

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40ug/0.2ml

Monoclonal Antibody for Bovine ADAM 10

Protein for Bovine ADAM 10

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types."
Howard L. , Mitchell S. , Lu X. , Griffiths S. , Glynn P.
Biochem. J.317:45-50(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
2.

"Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease."
Lammich S. , Kojro E. , Postina R. , Gilbert S. , Pfeiffer R. , Jasionowski M. , Haass C. , Fahrenholz F.
Proc. Natl. Acad. Sci. U.S.A.96:3922-3927(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 214-233;FUNCTION;MUTAGENESIS OF GLU-384
3.

NIH - Mammalian Gene Collection (MGC) project
Submitted (2007-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: Hereford.
tissue: Basal ganglia.
4.

"Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans."
Janes P.W. , Saha N. , Barton W.A. , Kolev M.V. , Wimmer-Kleikamp S.H. , Nievergall E. , Blobel C.P. , Himanen J.P. , Lackmann M. , Nikolov D.B.
Cell123:291-304(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 455-646;DISULFIDE BONDS;SUBUNIT;MUTAGENESIS OF GLU-573; GLU-578 AND GLU-579

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