ADAM10 ELISA Kit for Human(Homo sapiens) | EIAab.comADAM10 ELISA Kit for Human(Homo sapiens)

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ADAM10 (Gene name),

Disintegrin and metalloproteinase domain-containing protein 10 (Protein name ), ADA10_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ADAM10(KUZ;MADM);

Protein name:

Disintegrin and metalloproteinase domain-containing protein 10(ADAM 10);

Alternative:

Kuzbanian protein homolog;CDw156;Mammalian disintegrin-metalloprotease;

CD:

CD156c;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with EPHA2 (By similarity). Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function.

Function:

Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. May regulate the EFNA5-EPHA3 signaling.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Endomembrane system Single-pass type I membrane protein Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi.

Protein Attributes:

Sequence length:

748

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

748:

VHTPSSNPKL | PPPKPLPGTL | KRRRPPQPIQ | QPQRQRPRES | YQMGHMRR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:102

String:

O14672

MIM:

602192

UniGene:

Hs.578508

STRING:

9606.ENSP00000260408

SMR:

O14672

Pfam:

PF00200

Uniprot:

O14672

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ELISA Kit for Human ADAM 10

Cat.:

E0766h

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96T

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ELISA Kit for Human ADAM 10

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ELISA Kit for Human ADAM 10

Cat.:

E0766m

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96T

ELISA Kit for Human ADAM 10

Cat.:

E0766b

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96T

ELISA Kit for Human ADAM 10

Cat.:

E0766r

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96T

CLIA Kit for Human ADAM 10

Cat.:

U0766m

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96T

CLIA Kit for Human ADAM 10

MSDS:

Please sign in first.

CLIA Kit for Human ADAM 10

Cat.:

U0766h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human ADAM 10

Cat.:

U0766b

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96T

CLIA Kit for Human ADAM 10

Cat.:

U0766r

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96T

Polyclonal Antibody for Human ADAM 10

Cat.:

P0766Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human ADAM 10

Cat.:

P0766Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human ADAM 10

Cat.:

P0766Rb-r

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40ug/0.2ml

Monoclonal Antibody for Human ADAM 10

Protein for Human ADAM 10

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Identification and characterization of a pro-tumor necrosis factor-alpha-processing enzyme from the ADAM family of zinc metalloproteases."
Rosendahl M.S. , Ko S.C. , Long D.L. , Brewer M.T. , Rosenzweig B. , Hedl E. , Anderson L. , Pyle S.M. , Moreland J. , Meyers M.A. , Kohno T. , Lyons D. , Lichenstein H.S.
J. Biol. Chem.272:24588-24593(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 216-237
2.

"Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types."
Howard L. , Mitchell S. , Lu X. , Griffiths S. , Glynn P.
Biochem. J.317:45-50(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 109-748 (ISOFORM 1)
3.

"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C. , Garber M. , Sharpe T. , Young S.K. , Rowen L. , O'Neill K. , Whittaker C.A. , Kamal M. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Kodira C.D. , Madan A. , Qin S. , Yang X. , Abbasi N. , Abouelleil A. , more...
Nature440:671-675(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Placenta.
5.

"Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes."
McKie N. , Edwards T. , Dallas D.J. , Houghton A. , Stringer B. , Graham R. , Russell G. , Croucher P.I.
Biochem. Biophys. Res. Commun.230:335-339(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
6.

"ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles."
Gutwein P. , Mechtersheimer S. , Riedle S. , Stoeck A. , Gast D. , Joumaa S. , Zentgraf H. , Fogel M. , Altevogt P.
FASEB J.17:292-294(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein."
Vincent B. , Paitel E. , Saftig P. , Frobert Y. , Hartmann D. , De Strooper B. , Grassi J. , Lopez-Perez E. , Checler F.
J. Biol. Chem.276:37743-37746(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"ADAM-10 protein is present in human articular cartilage primarily in the membrane-bound form and is upregulated in osteoarthritis and in response to IL-1alpha in bovine nasal cartilage."
Chubinskaya S. , Mikhail R. , Deutsch A. , Tindal M.H.
J. Histochem. Cytochem.49:1165-1176(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
9.

"Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells."
Lemjabbar H. , Basbaum C.
Nat. Med.8:41-46(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans."
Janes P.W. , Saha N. , Barton W.A. , Kolev M.V. , Wimmer-Kleikamp S.H. , Nievergall E. , Blobel C.P. , Himanen J.P. , Lackmann M. , Nikolov D.B.
Cell123:291-304(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH EFNA5 AND EPHA3;FUNCTION IN EFNA5-EPHA3 SIGNALING
11.

"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
Lewandrowski U. , Moebius J. , Walter U. , Sickmann A.
Mol. Cell. Proteomics5:226-233(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-278
tissue: Platelet.
12.

"The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells."
Kirkin V. , Cahuzac N. , Guardiola-Serrano F. , Huault S. , Luckerath K. , Friedmann E. , Novac N. , Wels W.S. , Martoglio B. , Hueber A.O. , Zornig M.
Cell Death Differ.14:1678-1687(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CLEAVAGE OF FASLG
13.

"Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis."
Martin L. , Fluhrer R. , Haass C.
J. Biol. Chem.284:5662-5670(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CLEAVAGE OF ITM2B
14.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-278
tissue: Liver.
15.

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-278
tissue: Leukemic T-cell.
16.

"Junctional adhesion molecule-C is a soluble mediator of angiogenesis."
Rabquer B.J. , Amin M.A. , Teegala N. , Shaheen M.K. , Tsou P.S. , Ruth J.H. , Lesch C.A. , Imhof B.A. , Koch A.E.
J. Immunol.185:1777-1785(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CLEAVAGE OF JAM3
17.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"Ectodomain shedding and autocleavage of the cardiac membrane protease corin."
Jiang J. , Wu S. , Wang W. , Chen S. , Peng J. , Zhang X. , Wu Q.
J. Biol. Chem.286:10066-10072(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CLEAVAGE OF CORIN
19.

"Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity."
Kim M. , Suh J. , Romano D. , Truong M.H. , Mullin K. , Hooli B. , Norton D. , Tesco G. , Elliott K. , Wagner S.L. , Moir R.D. , Becker K.D. , Tanzi R.E.
Hum. Mol. Genet.18:3987-3996(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AD18 HIS-170 AND GLY-181;CHARACTERIZATION OF VARIANTS AD18 HIS-170 AND GLY-181
20.

"Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma."
Wei X. , Moncada-Pazos A. , Cal S. , Soria-Valles C. , Gartner J. , Rudloff U. , Lin J.C. , Rosenberg S.A. , Lopez-Otin C. , Samuels Y.
Hum. Mutat.32:E2148-E2175(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TYR-176
21.

"Whole-exome sequencing identifies ADAM10 mutations as a cause of reticulate acropigmentation of Kitamura, a clinical entity distinct from Dowling-Degos disease."
Kono M. , Sugiura K. , Suganuma M. , Hayashi M. , Takama H. , Suzuki T. , Matsunaga K. , Tomita Y. , Akiyama M.
Hum. Mol. Genet.22:3524-3533(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS RAK SER-139 AND TYR-524
22.

"ADAM10 missense mutations potentiate beta-amyloid accumulation by impairing prodomain chaperone function."
Suh J. , Choi S.H. , Romano D.M. , Gannon M.A. , Lesinski A.N. , Kim D.Y. , Tanzi R.E.
Neuron80:385-401(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS AD18 HIS-170 AND GLY-181

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