Adam10 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comAdam10 ELISA Kit for Rat(Rattus norvegicus)

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Adam10 (Gene name),

Disintegrin and metalloproteinase domain-containing protein 10 (Protein name ), ADA10_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Adam10(Madm);

Protein name:

Disintegrin and metalloproteinase domain-containing protein 10(ADAM 10);

Alternative:

Mammalian disintegrin-metalloprotease;Kuzbanian protein homolog;

CD:

CD156c;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function. Interacts with EPHA2.

Function:

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch. May regulate the EFNA5-EPHA3 signaling.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

544

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

544:

SSNPKLPPPK | PLPGTLKRRR | PPQPIQQPQR | QRPRESYQMG | HMRR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.42924

STRING:

10116.ENSRNOP00000021066

String:

Q10743

SMR:

Q10743

Pfam:

PF00200

Uniprot:

Q10743

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ELISA Kit for Rat ADAM 10

Cat.:

E0766h

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96T

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ELISA Kit for Rat ADAM 10

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ELISA Kit for Rat ADAM 10

Cat.:

E0766m

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Packing:

96T

ELISA Kit for Rat ADAM 10

Cat.:

E0766b

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Packing:

96T

ELISA Kit for Rat ADAM 10

Cat.:

E0766r

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Packing:

96T

CLIA Kit for Rat ADAM 10

Cat.:

U0766m

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Packing:

96T

CLIA Kit for Rat ADAM 10

MSDS:

Please sign in first.

CLIA Kit for Rat ADAM 10

Cat.:

U0766h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Rat ADAM 10

Cat.:

U0766b

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MSDS:

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Packing:

96T

CLIA Kit for Rat ADAM 10

Cat.:

U0766r

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96T

Polyclonal Antibody for Rat ADAM 10

Cat.:

P0766Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat ADAM 10

Cat.:

P0766Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat ADAM 10

Cat.:

P0766Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat ADAM 10

Protein for Rat ADAM 10

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular cloning of MADM: a catalytically active mammalian disintegrin-metalloprotease expressed in various cell types."
Howard L. , Mitchell S. , Lu X. , Griffiths S. , Glynn P.
Biochem. J.317:45-50(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Sprague-Dawley.
tissue: Brain.

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