Gene name:
ADRA1A (ADRA1C) ;
Protein name:
Alpha-1A adrenergic receptor ;
Alternative:
Alpha-1C adrenergic receptor ;Alpha-1A adrenoreceptor (Alpha-1A adrenoceptor) ;Alpha-adrenergic receptor 1c ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Protein Attributes:
50:
MVFLSGNASD | SSNCTQPPAP | VNISKAILLG | VILGGLILFG | VLGNILVILS |
100:
VACHRHLHSV | THYYIVNLAV | ADLLLTSTVL | PFSAIFEVLG | YWAFGRVFCN |
150:
IWAAVDVLCC | TASIMGLCII | SIDRYIGVSY | PLRYPTIVTQ | RRGLMALLCV |
200:
WALSLVISIG | PLFGWRQPAP | EDETICQINE | EPGYVLFSAL | GSFYLPLAII |
250:
LVMYCRVYVV | AKRESRGLKS | GLKTDKSDSE | QVTLRIHRKN | APAGGSGMAS |
300:
AKTKTHFSVR | LLKFSREKKA | AKTLGIVVGC | FVLCWLPFFL | VMPIGSFFPD |
350:
FKPSETVFKI | VFWLGYLNSC | INPIIYPCSS | QEFKKAFQNV | LRIQCLCRKQ |
400:
SSKHALGYTL | HPPSQAVEGQ | HKDMVRIPVG | SRETFYRISK | TDGVCEWKFF |
450:
SSMPRGSARI | TVSKDQSSCT | TARVRSKSFL | QVCCCVGPST | PSLDKNHQVP |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Dog
Bovine
Rabbit
ELISA Kit for Human Alpha-1A adrenergic receptor
ELISA Kit for Human Alpha-1A adrenergic receptor
ELISA Kit for Human Alpha-1A adrenergic receptor
ELISA Kit for Human Alpha-1A adrenergic receptor
ELISA Kit for Human Alpha-1A adrenergic receptor
ELISA Kit for Human Alpha-1A adrenergic receptor
CLIA Kit for Human Alpha-1A adrenergic receptor
CLIA Kit for Human Alpha-1A adrenergic receptor
CLIA Kit for Human Alpha-1A adrenergic receptor
CLIA Kit for Human Alpha-1A adrenergic receptor
CLIA Kit for Human Alpha-1A adrenergic receptor
CLIA Kit for Human Alpha-1A adrenergic receptor
Polyclonal Antibody for Human Alpha-1A adrenergic receptor
Polyclonal Antibody for Human Alpha-1A adrenergic receptor
Polyclonal Antibody for Human Alpha-1A adrenergic receptor
Polyclonal Antibody for Human Alpha-1A adrenergic receptor
Polyclonal Antibody for Human Alpha-1A adrenergic receptor
Polyclonal Antibody for Human Alpha-1A adrenergic receptor
Monoclonal Antibody for Human Alpha-1A adrenergic receptor
Monoclonal Antibody for Human Alpha-1A adrenergic receptor
Monoclonal Antibody for Human Alpha-1A adrenergic receptor
Monoclonal Antibody for Human Alpha-1A adrenergic receptor
Monoclonal Antibody for Human Alpha-1A adrenergic receptor
Monoclonal Antibody for Human Alpha-1A adrenergic receptor
Protein for Human Alpha-1A adrenergic receptor
Protein for Human Alpha-1A adrenergic receptor
Protein for Human Alpha-1A adrenergic receptor
Protein for Human Alpha-1A adrenergic receptor
Protein for Human Alpha-1A adrenergic receptor
Protein for Human Alpha-1A adrenergic receptor
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);VARIANT ARG-347
tissue :
Prostate .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ARG-347
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Heart .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
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Hippocampus .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3);VARIANT ARG-347;TISSUE SPECIFICITY
tissue :
Prostate .
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"Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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"Molecular cloning, genomic characterization and expression of novel human alpha1A-adrenoceptor isoforms."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);TISSUE SPECIFICITY
tissue :
Prostate .
8.
"Truncated isoforms inhibit [3H]prazosin binding and cellular trafficking of native human alpha1A-adrenoceptors."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5; 6; 7; 8 AND 9)
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Liver .
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"RT-PCR cloning and sequence analysis of adrenergic receptor subtype-alpha-1a cDNA from human prostrate cell-line DU-145."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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"Complete sequencing and characterization of 21,243 full-length human cDNAs."
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more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Cerebellum .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ARG-347
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 52-400 (ISOFORMS 1/2/3/4);TISSUE SPECIFICITY;VARIANT ARG-347
tissue :
Prostate .
16.
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Cited for : SUBCELLULAR LOCATION;FUNCTION
17.
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Cited for : SUBCELLULAR LOCATION;SUBUNIT;FUNCTION;MUTAGENESIS OF LYS-334; LYS-335; ARG-342; ARG-348 AND LYS-349
18.
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Cited for : VARIANT ARG-347
19.
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Cited for : VARIANT ARG-347
20.
"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T.
,
Jones S.
,
Wood L.D.
,
Parsons D.W.
,
Lin J.
,
Barber T.D.
,
Mandelker D.
,
Leary R.J.
,
Ptak J.
,
Silliman N.
,
Szabo S.
,
Buckhaults P.
,
Farrell C.
,
Meeh P.
,
Markowitz S.D.
,
Willis J.
,
Dawson D.
,
Willson J.K.V.
,
Gazdar A.F.
,
Hartigan J.
,
Wu L.
,
Liu C.
,
Parmigiani G.
,
Park B.H.
,
Bachman K.E.
,
Papadopoulos N.
,
Vogelstein B.
,
Kinzler K.W.
,
Velculescu V.E.
more...
Science314:268-274(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANT [LARGE SCALE ANALYSIS] TRP-40