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Index > Protein center > ADRA1A(Gene name) > Human
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  • ADRA1A (Gene name),
  • Alpha-1A adrenergic receptor (Protein name ),  ADA1A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    ADRA1A(ADRA1C);
    Protein name:
    Alpha-1A adrenergic receptor;
    Alternative:
    Alpha-1C adrenergic receptor;Alpha-1A adrenoreceptor(Alpha-1A adrenoceptor);Alpha-adrenergic receptor 1c;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    466
    Sequence:
    50:
    MVFLSGNASD | SSNCTQPPAP | VNISKAILLG | VILGGLILFG | VLGNILVILS | 
    100:
    VACHRHLHSV | THYYIVNLAV | ADLLLTSTVL | PFSAIFEVLG | YWAFGRVFCN | 
    150:
    IWAAVDVLCC | TASIMGLCII | SIDRYIGVSY | PLRYPTIVTQ | RRGLMALLCV | 
    200:
    WALSLVISIG | PLFGWRQPAP | EDETICQINE | EPGYVLFSAL | GSFYLPLAII | 
    250:
    LVMYCRVYVV | AKRESRGLKS | GLKTDKSDSE | QVTLRIHRKN | APAGGSGMAS | 
    300:
    AKTKTHFSVR | LLKFSREKKA | AKTLGIVVGC | FVLCWLPFFL | VMPIGSFFPD | 
    350:
    FKPSETVFKI | VFWLGYLNSC | INPIIYPCSS | QEFKKAFQNV | LRIQCLCRKQ | 
    400:
    SSKHALGYTL | HPPSQAVEGQ | HKDMVRIPVG | SRETFYRISK | TDGVCEWKFF | 
    450:
    SSMPRGSARI | TVSKDQSSCT | TARVRSKSFL | QVCCCVGPST | PSLDKNHQVP | 
    466:
    TIKVHTISLS | ENGEEV
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    SMR:
    MIM:
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Alpha-1A adrenergic receptor
    Cat.:
    E1298h
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    Packing:
    96T
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    ELISA Kit for Human Alpha-1A adrenergic receptor
    Cat.:
    E1298r
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    ELISA Kit for Human Alpha-1A adrenergic receptor
    Cat.:
    E1298m
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    ELISA Kit for Human Alpha-1A adrenergic receptor
    MSDS:
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    ELISA Kit for Human Alpha-1A adrenergic receptor
    MSDS:
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    ELISA Kit for Human Alpha-1A adrenergic receptor
    MSDS:
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    CLIA Kit for Human Alpha-1A adrenergic receptor
    Cat.:
    U1298b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Alpha-1A adrenergic receptor
    MSDS:
    Please sign in first.
    CLIA Kit for Human Alpha-1A adrenergic receptor
    MSDS:
    Please sign in first.
    CLIA Kit for Human Alpha-1A adrenergic receptor
    Cat.:
    U1298m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Alpha-1A adrenergic receptor
    Cat.:
    U1298r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Alpha-1A adrenergic receptor
    Cat.:
    U1298h
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    Polyclonal Antibody for Human Alpha-1A adrenergic receptor
    Polyclonal Antibody for Human Alpha-1A adrenergic receptor
    Cat.:
    P1298Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Alpha-1A adrenergic receptor
    Cat.:
    P1298Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Alpha-1A adrenergic receptor
    Cat.:
    P1298Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Alpha-1A adrenergic receptor
    Polyclonal Antibody for Human Alpha-1A adrenergic receptor
    Monoclonal Antibody for Human Alpha-1A adrenergic receptor
    Monoclonal Antibody for Human Alpha-1A adrenergic receptor
    Monoclonal Antibody for Human Alpha-1A adrenergic receptor
    Monoclonal Antibody for Human Alpha-1A adrenergic receptor
    Monoclonal Antibody for Human Alpha-1A adrenergic receptor
    Monoclonal Antibody for Human Alpha-1A adrenergic receptor
    Protein for Human Alpha-1A adrenergic receptor
    Protein for Human Alpha-1A adrenergic receptor
    Protein for Human Alpha-1A adrenergic receptor
    Protein for Human Alpha-1A adrenergic receptor
    Protein for Human Alpha-1A adrenergic receptor
    Protein for Human Alpha-1A adrenergic receptor

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor."
      Hirasawa A. , Horie K. , Tanaka T. , Takagaki K. , Murai M. , Yano J. , Tsujimoto G.
      Biochem. Biophys. Res. Commun.195:902-909(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);VARIANT ARG-347
      tissue: Prostate.
    2. 2.
      "Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c."
      Weinberg D.H. , Trivedi P. , Tan C.P. , Mitra S. , Perkins-Barrow A. , Borkowski D. , Strader C.D. , Bayne M.
      Biochem. Biophys. Res. Commun.201:1296-1304(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ARG-347
      tissue: Heart.
    3. 3.
      "The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype."
      Forray C. , Bard J.A. , Wetzel J.M. , Chiu G. , Shapiro E. , Tang R. , Lepor H. , Hartig P.R. , Weinshank R.L. , Branchek T.A. , Gluchowski C.
      Mol. Pharmacol.45:703-708(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
      tissue: Hippocampus.
      tissue: Lymphocyte.
    4. 4.
      "The alpha 1C-adrenoceptor in human prostate: cloning, functional expression, and localization to specific prostatic cell types."
      Tseng-Crank J. , Kost T. , Goetz A. , Hazum S. , Roberson K.M. , Haizlip J. , Godinot N. , Robertson C.N. , Saussy D.
      Br. J. Pharmacol.115:1475-1485(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ARG-347
    5. 5.
      "Cloning, functional expression and tissue distribution of human alpha 1c-adrenoceptor splice variants."
      Hirasawa A. , Shibata K. , Horie K. , Takei Y. , Obika K. , Tanaka T. , Muramoto N. , Takagaki K. , Yano J. , Tsujimoto G.
      FEBS Lett.363:256-260(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3);VARIANT ARG-347;TISSUE SPECIFICITY
      tissue: Prostate.
    6. 6.
      "Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues."
      Schwinn D.A. , Johnston G.I. , Page S.O. , Mosley M.J. , Wilson K.H. , Worman N.P. , Campbell S. , Fidock M.D. , Furness L.M. , Parry-Smith D.J. , Peter B. , Bailey D.S.
      J. Pharmacol. Exp. Ther.272:134-142(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ARG-347
    7. 7.
      "Molecular cloning, genomic characterization and expression of novel human alpha1A-adrenoceptor isoforms."
      Chang D.J. , Chang T.K. , Yamanishi S.S. , Salazar F.H.R. , Kosaka A.H. , Khare R. , Bhakta S. , Jasper J.R. , Shieh I.-S. , Lesnick J.D. , Ford A.P.D.W. , Daniels D.V. , Clarke D.E. , Bach C.T. , Chan H.W.
      FEBS Lett.422:279-283(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);TISSUE SPECIFICITY
      tissue: Prostate.
    8. 8.
      "Truncated isoforms inhibit [3H]prazosin binding and cellular trafficking of native human alpha1A-adrenoceptors."
      Coge F. , Guenin S.P. , Renouard-Try A. , Rique H. , Ouvry C. , Fabry N. , Beauverger P. , Nicolas J.P. , Galizzi J.-P. , Boutin J.A. , Canet E.
      Biochem. J.343:231-239(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5; 6; 7; 8 AND 9)
      tissue: Liver.
    9. 9.
      "RT-PCR cloning and sequence analysis of adrenergic receptor subtype-alpha-1a cDNA from human prostrate cell-line DU-145."
      Banerjee A.G.N. , Aarti A.
      Submitted (2001-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    10. 10.
      "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M. , Sato T. , Okouchi I. , Arita M. , Futami K. , Matsumoto S. , Tsutsumi S. , Aburatani H. , Asai K. , Akiyama Y.
      Submitted (2001-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    11. 11.
      "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A. , Aronstam R.S. , Sharma S.V.
      Submitted (2003-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    12. 12.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Cerebellum.
    13. 13.
      NHLBI resequencing and genotyping service (RS&G)
      Submitted (2007-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    14. 14.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ARG-347
    15. 15.
      "Identification of alpha 1-adrenoceptor subtypes present in the human prostate."
      Faure C. , Pimoule C. , Vallancien G. , Langer S.Z. , Graham D.
      Life Sci.54:1595-1605(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 52-400 (ISOFORMS 1/2/3/4);TISSUE SPECIFICITY;VARIANT ARG-347
      tissue: Prostate.
    16. 16.
      "Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes."
      Wright C.D. , Chen Q. , Baye N.L. , Huang Y. , Healy C.L. , Kasinathan S. , O'Connell T.D.
      Circ. Res.103:992-1000(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;FUNCTION
    17. 17.
      "Nuclear localization drives alpha1-adrenergic receptor oligomerization and signaling in cardiac myocytes."
      Wright C.D. , Wu S.C. , Dahl E.F. , Sazama A.J. , O'Connell T.D.
      Cell. Signal.24:794-802(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;SUBUNIT;FUNCTION;MUTAGENESIS OF LYS-334; LYS-335; ARG-342; ARG-348 AND LYS-349
    18. 18.
      "Alpha 1a-adrenoceptor polymorphism: pharmacological characterization and association with benign prostatic hypertrophy."
      Shibata K. , Hirasawa A. , Moriyama N. , Kawabe K. , Ogawa S. , Tsujimoto G.
      Br. J. Pharmacol.118:1403-1408(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARG-347
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARG-347
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] TRP-40
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