ADA ELISA Kit for Human(Homo sapiens) | EIAab.comADA ELISA Kit for Human(Homo sapiens)

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ADA (Gene name),

Adenosine deaminase (Protein name ), ADA_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ADA(ADA1);

Protein name:

Adenosine deaminase;

Alternative:

Adenosine aminohydrolase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with DPP4 (extracellular domain).

Function:

Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion.

Subcellular Location:

Cell membrane Peripheral membrane protein Extracellular side Cell junction Cytoplasmic vesicle lumen Cytoplasm Colocalized with DPP4 at the cell junction in lymphocyte-epithelial cell adhesion.

Protein Attributes:

Sequence length:

363

Sequence:

50:

100:

150:

200:

250:

300:

350:

363:

YGMPPSASAG | QNL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P00813

STRING:

9606.ENSP00000361965

String:

P00813

Pfam:

PF00962

UniGene:

Hs.654536

KEGG:

hsa:100

MIM:

102700

Uniprot:

P00813

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ELISA Kit for Human Adenosine deaminase

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E1390h

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ELISA Kit for Human Adenosine deaminase

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E1390b

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96T

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ELISA Kit for Human Adenosine deaminase

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E1390r

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ELISA Kit for Human Adenosine deaminase

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E1390m

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ELISA Kit for Human Adenosine deaminase

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E1390c

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96T

CLIA Kit for Human Adenosine deaminase

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U1390h

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96T

CLIA Kit for Human Adenosine deaminase

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U1390r

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96T

CLIA Kit for Human Adenosine deaminase

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U1390b

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96T

CLIA Kit for Human Adenosine deaminase

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U1390m

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96T

CLIA Kit for Human Adenosine deaminase

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U1390c

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Polyclonal Antibody for Human Adenosine deaminase

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P1390Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Adenosine deaminase

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P1390Rb-m

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Polyclonal Antibody for Human Adenosine deaminase

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P1390Rb-h

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Polyclonal Antibody for Human Adenosine deaminase

Monoclonal Antibody for Human Adenosine deaminase

Protein for Human Adenosine deaminase

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Human adenosine deaminase. cDNA and complete primary amino acid sequence."
Daddona P.E. , Shewach D.S. , Kelley W.N. , Argos P. , Markham A.F. , Orkin S.H.
J. Biol. Chem.259:12101-12106(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Sequence of human adenosine deaminase cDNA including the coding region and a small intron."
Wiginton D.A. , Adrian G.S. , Hutton J.J.
Nucleic Acids Res.12:2439-2446(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Adenosine deaminase: characterization and expression of a gene with a remarkable promoter."
Valerio D. , Duyvesteyn M.G.C. , Dekker B.M.M. , Weeda G. , Berkvens T.M. , van der Voorn L. , van Ormondt H. , van der Eb A.J.
EMBO J.4:437-443(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Complete sequence and structure of the gene for human adenosine deaminase."
Wiginton D.A. , Kaplan D.J. , States J.C. , Akeson A.L. , Perme C.M. , Bilyk I.J. , Vaughn A.J. , Lattier D.L. , Hutton J.J.
Biochemistry25:8234-8244(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Thymus.
6.

"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
tissue: Placenta.
8.

Bienvenut W.V.
Submitted (2004-08) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-11;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue: B-cell lymphoma.
9.

"Molecular cloning of human adenosine deaminase gene sequences."
Orkin S.H. , Daddona P.E. , Shewach D.S. , Markham A.F. , Bruns G.A. , Goff S.C. , Kelley W.N.
J. Biol. Chem.258:12753-12756(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 141-363
10.

"Direct association of adenosine deaminase with a T cell activation antigen, CD26."
Kameoka J. , Tanaka T. , Nojima Y. , Schlossman S.F. , Morimoto C.
Science261:466-469(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DPP4;SUBCELLULAR LOCATION
11.

"Binding of adenosine deaminase to the lymphocyte surface via CD26."
De Meester I. , Vanham G. , Kestens L. , Vanhoof G. , Bosmans E. , Gigase P. , Scharpe S.
Eur. J. Immunol.24:566-570(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DPP4
12.

"Molecular characterization of dipeptidyl peptidase activity in serum: soluble CD26/dipeptidyl peptidase IV is responsible for the release of X-Pro dipeptides."
Durinx C. , Lambeir A.M. , Bosmans E. , Falmagne J.B. , Berghmans R. , Haemers A. , Scharpe S. , De Meester I.
Eur. J. Biochem.267:5608-5613(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DPP4
13.

"Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase-CD26 interaction."
Gines S. , Marino M. , Mallol J. , Canela E.I. , Morimoto C. , Callebaut C. , Hovanessian A. , Casado V. , Lluis C. , Franco R.
Biochem. J.361:203-209(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
14.

"N-linked glycosylation of dipeptidyl peptidase IV (CD26): effects on enzyme activity, homodimer formation, and adenosine deaminase binding."
Aertgeerts K. , Ye S. , Shi L. , Prasad S.G. , Witmer D. , Chi E. , Sang B.C. , Wijnands R.A. , Webb D.R. , Swanson R.V.
Protein Sci.13:145-154(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APP4
15.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
16.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-54 AND LYS-232;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"The crystal structure of human adenosine deaminase."
Structural genomics consortium (SGC)
Submitted (2009-08) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.52 ANGSTROMS) OF 5-363 IN COMPLEX WITH NICKEL IONS AND 2-DEAOXYADENOSINE;COFACTOR
19.

"Hot spot mutations in adenosine deaminase deficiency."
Hirschhorn R. , Tzall S. , Ellenbogen A.
Proc. Natl. Acad. Sci. U.S.A.87:6171-6175(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ADASCID TRP-76; PRO-107; GLN-149; CYS-211; THR-215 AND LEU-274
20.

"An Asp8Asn substitution results in the adenosine deaminase (ADA) genetic polymorphism (ADA 2 allozyme): occurrence on different chromosomal backgrounds and apparent intragenic crossover."
Hirschhorn R. , Yang D.R. , Israni A.
Ann. Hum. Genet.58:1-9(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ADA*2 ASN-8
21.

"Structure of adenosine deaminase mRNAs from normal and adenosine deaminase-deficient human cell lines."
Adrian G.S. , Wiginton D.A. , Hutton J.
Mol. Cell. Biol.4:1712-1717(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ADASCID
22.

"Identification of a point mutation in the adenosine deaminase gene responsible for immunodeficiency."
Bonthron D.T. , Markham A.F. , Ginsburg D. , Orkin S.H.
J. Clin. Invest.76:894-897(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ADASCID GLN-101
23.

"Mutant human adenosine deaminase alleles and their expression by transfection into fibroblasts."
Akeson A.L. , Wiginton D.A. , Dusing M.R. , States J.C. , Hutton J.J.
J. Biol. Chem.263:16291-16296(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ADASCID TRP-101; HIS-211 AND VAL-329
24.

"Identification of a point mutation resulting in a heat-labile adenosine deaminase (ADA) in two unrelated children with partial ADA deficiency."
Hirschhorn R. , Tzall S. , Ellenbogen A. , Orkin S.H.
J. Clin. Invest.83:497-501(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ADASCID GLN-297
25.

"Identification of two new missense mutations (R156C and S291L) in two ADA-SCID patients unusual for response to therapy with partial exchange transfusions."
Hirschhorn R.
Hum. Mutat.1:166-168(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ADASCID CYS-156 AND LEU-291
26.

"Novel splicing, missense, and deletion mutations in seven adenosine deaminase-deficient patients with late/delayed onset of combined immunodeficiency disease. Contribution of genotype to phenotype."
Santisteban I. , Arredondo-Vega F.X. , Kelly S. , Mary A. , Fischer A. , Hummell D.S. , Lawton A. , Sorensen R.U. , Stiehm E.R. , Uribe L. , Weinberg K. , Hershfield M.S.
J. Clin. Invest.92:2291-2302(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ADASCID LEU-101; HIS-156; MET-177; ARG-216 AND LEU-291
27.

"Homozygosity for a missense mutation (G20R) associated with neonatal onset adenosine deaminase-deficient severe combined immunodeficiency (ADA-SCID)."
Yang D.R. , Huie M.L. , Hirschhorn R.
Clin. Immunol. Immunopathol.70:171-175(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ADASCID ARG-20
28.

"Three new adenosine deaminase mutations that define a splicing enhancer and cause severe and partial phenotypes: implications for evolution of a CpG hotspot and expression of a transduced ADA cDNA."
Santisteban I. , Arredondo-Vega F.X. , Kelly S. , Loubser M. , Meydan N. , Roifman C. , Howell P.L. , Bowen T. , Weinberg K.I. , Schroeder M.L. , Hershfield M.S.
Hum. Mol. Genet.4:2081-2087(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ARG-80 AND GLN-142
29.

"Four new adenosine deaminase mutations, altering a zinc-binding histidine, two conserved alanines, and a 5' splice site."
Santisteban I. , Arredondo-Vega F.X. , Kelly S. , Debre M. , Fisher A. , Perignon J.L. , Hilman B. , Eldahr J. , Dreyfus D.H. , Gelfand E.W. , Howell P.L. , Hershfield M.S.
Hum. Mutat.5:243-250(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ADASCID ASP-15; ASP-83 AND ASP-179
30.

"Two newly identified mutations (Thr233Ile and Leu152Met) in partially adenosine deaminase-deficient (ADA-) individuals that result in differing biochemical and metabolic phenotypes."
Hirschhorn R. , Borkowsky W. , Jiang C.-K. , Yang D.R. , Jenkins T.
Hum. Genet.100:22-29(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MET-152 AND ILE-233
31.

"Seven novel mutations in the adenosine deaminase (ADA) gene in patients with severe and delayed onset combined immunodeficiency: G74C, V129M, G140E, R149W, Q199P, 462delG, and E337del."
Arrendondo-Vega F.X. , Santisteban I. , Notarangelo L.D. , El Dahr J. , Buckley R. , Roifman C. , Conley M.E. , Hershfield M.S.
Hum. Mutat.11:482-482(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ADASCID CYS-74; MET-129; GLU-140; TRP-149 AND PRO-199
32.

"A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans."
Retey J.V. , Adam M. , Honegger E. , Khatami R. , Luhmann U.F.O. , Jung H.H. , Berger W. , Landolt H.-P.
Proc. Natl. Acad. Sci. U.S.A.102:15676-15681(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: EFFECT OF VARIANT ADA*2 ASN-8 ON SLEEP
33.

"Core signaling pathways in human pancreatic cancers revealed by global genomic analyses."
Jones S. , Zhang X. , Parsons D.W. , Lin J.C. , Leary R.J. , Angenendt P. , Mankoo P. , Carter H. , Kamiyama H. , Jimeno A. , Hong S.M. , Fu B. , Lin M.T. , Calhoun E.S. , Kamiyama M. , Walter K. , Nikolskaya T. , Nikolsky Y. , more...
Science321:1801-1806(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-142

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