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Index > Protein center > ADM(Gene name) > Human
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  • ADM (Gene name),
  • ADM (Protein name ),  ADML_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (2)
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  • Gene name:
    ADM(AM);
    Protein name:
    ADM;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    185
    Sequence:
    50:
    MKLVSVALMY | LGSLAFLGAD | TARLDVASEF | RKKWNKWALS | RGKRELRMSS | 
    100:
    SYPTGLADVK | AGPAQTLIRP | QDMKGASRSP | EDSSPDAARI | RVKRYRQSMN | 
    150:
    NFQGLRSFGC | RFGTCTVQKL | AHQIYQFTDK | DKDNVAPRSK | ISPQGYGRRR | 
    185:
    RRSLPEAGPG | RTLVSSKPQA | HGAPAPPSGS | APHFL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    MIM:
    String:
    KEGG:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human ADM
    Cat.:
    E0220b
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    Packing:
    96T
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    ELISA Kit for Human ADM
    Cat.:
    E0220h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human ADM
    Cat.:
    E0220p
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human ADM
    Cat.:
    E0220d
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human ADM
    Cat.:
    E0220m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human ADM
    Cat.:
    E0220r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human ADM
    Cat.:
    U0220r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human ADM
    Cat.:
    U0220m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human ADM
    Cat.:
    U0220b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human ADM
    Cat.:
    U0220h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human ADM
    Cat.:
    U0220d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human ADM
    Cat.:
    U0220p
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human ADM
    Polyclonal Antibody for Human ADM
    Cat.:
    P0220Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human ADM
    Polyclonal Antibody for Human ADM
    Polyclonal Antibody for Human ADM
    Cat.:
    P0220Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human ADM
    Cat.:
    P0220Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human ADM
    Monoclonal Antibody for Human ADM
    Monoclonal Antibody for Human ADM
    Monoclonal Antibody for Human ADM
    Monoclonal Antibody for Human ADM
    Monoclonal Antibody for Human ADM
    Protein for Human ADM
    Protein for Human ADM
    Protein for Human ADM
    Protein for Human ADM
    Protein for Human ADM
    Protein for Human ADM

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    References
    1. 1.
      "Cloning and characterization of cDNA encoding a precursor for human adrenomedullin."
      Kitamura K. , Sakata J. , Kangawa K. , Kojima M. , Matsuo H. , Eto T.
      Biochem. Biophys. Res. Commun.194:720-725(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Pheochromocytoma.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Liver.
    3. 3.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain cortex.
    6. 6.
      NIEHS SNPs program
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ARG-50
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Kidney.
    9. 9.
      "Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma."
      Kitamura K. , Kangawa K. , Kawamoto M. , Ichiki Y. , Nakamura S. , Matsuo H. , Eto T.
      Biochem. Biophys. Res. Commun.192:553-560(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 95-146;AMIDATION AT TYR-146;DISULFIDE BOND
      tissue: Pheochromocytoma.
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    11. 11.
      "Structure-activity relationships of adrenomedullin in the circulation and adrenal gland."
      Champion H.C. , Nussdorfer G.G. , Kadowitz P.J.
      Regul. Pept.85:1-8(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    12. 12.
      "NMR conformational analysis of proadrenomedullin N-terminal 20 peptide, a proangiogenic factor involved in tumor growth."
      Lucyk S. , Taha H. , Yamamoto H. , Miskolzie M. , Kotovych G.
      Biopolymers81:295-308(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 22-41;AMIDATION AT ARG-41
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