AHR ELISA Kit for Human(Homo sapiens) | EIAab.comAHR ELISA Kit for Human(Homo sapiens)

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Index > Protein center > AHR(Gene name) > Human

AHR (Gene name),

Aryl hydrocarbon receptor (Protein name ), AHR_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

AHR(BHLHE76);

Protein name:

Aryl hydrocarbon receptor(Ah receptor;AhR);

Alternative:

Class E basic helix-loop-helix protein 76(bHLHe76);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds MYBBP1A (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. In the nucleus, heterodimer of AHR and ARNT. Interacts with coactivators including SRC-1, RIP140 and NOCA7, and with the corepressor SMRT. Interacts with NEDD8 and IVNS1ABP.

Function:

Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues.

Subcellular Location:

Cytoplasm Nucleus Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus.

Protein Attributes:

Sequence length:

848

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

848:

KFQNGVLNET | YPAELNNINN | TQTTTHLQPL | HHPSEARPFP | DLTSSGFL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P35869

UniGene:

Hs.171189

STRING:

9606.ENSP00000242057

MIM:

600253

SMR:

P35869

Pfam:

PF00010

KEGG:

hsa:196

Uniprot:

P35869

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ELISA Kit for Human Ah receptor

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E1354h

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96T

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ELISA Kit for Human Ah receptor

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E1354m

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96T

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ELISA Kit for Human Ah receptor

Cat.:

E1354r

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ELISA Kit for Human Ah receptor

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CLIA Kit for Human Ah receptor

Cat.:

U1354r

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Packing:

96T

CLIA Kit for Human Ah receptor

Cat.:

U1354m

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Packing:

96T

CLIA Kit for Human Ah receptor

MSDS:

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CLIA Kit for Human Ah receptor

Cat.:

U1354h

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96T

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Polyclonal Antibody for Human Ah receptor

Cat.:

P1354Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Ah receptor

Cat.:

P1354Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Ah receptor

Cat.:

P1354Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Ah receptor

Monoclonal Antibody for Human Ah receptor

Protein for Human Ah receptor

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Human Ah receptor cDNA: analysis for highly conserved sequences."
Itoh S. , Kamataki T.
Nucleic Acids Res.21:3578-3578(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Liver.
2.

"Cloning and expression of a human Ah receptor cDNA."
Dolwick K.M. , Schmidt J.V. , Carver L.A. , Swanson H.I. , Bradfield C.A.
Mol. Pharmacol.44:911-917(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
3.

"Human arylhydrocarbon receptor: functional expression and chromosomal assignment to 7p21."
Ema M. , Matsushita N. , Sogawa K. , Ariyama T. , Inazawa J. , Nemoto T. , Ota M. , Oshimura M. , Fujii-Kuriyama Y.
J. Biochem.116:845-851(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Human chromosome 7: DNA sequence and biology."
Scherer S.W. , Cheung J. , MacDonald J.R. , Osborne L.R. , Nakabayashi K. , Herbrick J.-A. , Carson A.R. , Parker-Katiraee L. , Skaug J. , Khaja R. , Zhang J. , Hudek A.K. , Li M. , Haddad M. , Duggan G.E. , Fernandez B.A. , Kanematsu E. , Gentles S. , more...
Science300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The DNA sequence of human chromosome 7."
Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Placenta.
8.

"Complete structural characterisation of the human aryl hydrocarbon receptor gene."
Bennett P. , Ramsden D.B. , Williams A.C.
Clin. Mol. Pathol.49:M12-M16(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-235; 388-461 AND 764-848
9.

"Interindividual difference in expression of human Ah receptor and related P450 genes."
Hayashi S. , Watanabe J. , Nakachi K. , Eguchi H. , Gotoh O. , Kawajiri K.
Carcinogenesis15:801-806(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 236-341;TISSUE SPECIFICITY
10.

"Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors."
Ema M. , Ohe N. , Suzuki M. , Mimura J. , Sogawa K. , Ikawa S. , Fujii-Kuriyama Y.
J. Biol. Chem.269:27337-27343(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF VAL-381
11.

"Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex."
Nguyen T.A. , Hoivik D. , Lee J.-E. , Safe S.
Arch. Biochem. Biophys.367:250-257(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT
12.

"Cell-specific regulation of human aryl hydrocarbon receptor expression by transforming growth factor-beta(1)."
Wolff S. , Harper P.A. , Wong J.M.Y. , Mostert V. , Wang Y. , Abel J.
Mol. Pharmacol.59:716-724(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
13.

"Role of the aryl hydrocarbon receptor in cell cycle regulation."
Puga A. , Xia Y. , Elferink C.
Chem. Biol. Interact.141:117-130(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN CELL CYCLE
14.

"Interaction with Nedd8, a ubiquitin-like protein, enhances the transcriptional activity of the aryl hydrocarbon receptor."
Antenos M. , Casper R.F. , Brown T.J.
J. Biol. Chem.277:44028-44034(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NEDD8
15.

"The aryl hydrocarbon receptor signaling pathway is modified through interactions with a Kelch protein."
Dunham E.E. , Stevens E.A. , Glover E. , Bradfield C.A.
Mol. Pharmacol.70:8-15(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IVNS1ABP
16.

"Polymorphisms in the human AH receptor."
Harper P.A. , Wong J.M.Y. , Lam M.S.M. , Okey A.B.
Chem. Biol. Interact.141:161-187(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON VARIANTS
17.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"Polymorphisms of human Ah receptor gene are not involved in lung cancer."
Kawajiri K. , Watanabe J. , Eguchi H. , Nakachi K. , Kiyohara C. , Hayashi S.
Pharmacogenetics5:151-158(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LYS-554
19.

"Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms."
Smart J. , Daly A.K.
Pharmacogenetics10:11-24(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LYS-554 AND ILE-570
20.

"Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer."
Cauchi S. , Stucker I. , Solas C. , Laurent-Puig P. , Cenee S. , Hemon D. , Jacquet M. , Kremers P. , Beaune P. , Massaad-Massade L.
Carcinogenesis22:1819-1824(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LYS-554 AND VAL-786
21.

"Human aryl hydrocarbon receptor polymorphisms that result in loss of CYP1A1 induction."
Wong J.M.Y. , Okey A.B. , Harper P.A.
Biochem. Biophys. Res. Commun.288:990-996(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SER-517 AND ILE-570

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