Protein name:
Aldo-keto reductase family 1 member C4;
Alternative:
1.1.1.357;3-alpha-hydroxysteroid dehydrogenase type I);3-alpha-HSD1;Dihydrodiol dehydrogenase 4(DD-4;DD4);1.1.1.225;Chlordecone reductase(CDR);HAKRA;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MDPKYQRVEL | NDGHFMPVLG | FGTYAPPEVP | RNRAVEVTKL | AIEAGFRHID |
100:
SAYLYNNEEQ | VGLAIRSKIA | DGSVKREDIF | YTSKLWCTFF | QPQMVQPALE |
150:
SSLKKLQLDY | VDLYLLHFPM | ALKPGETPLP | KDENGKVIFD | TVDLSATWEV |
200:
MEKCKDAGLA | KSIGVSNFNC | RQLEMILNKP | GLKYKPVCNQ | VECHPYLNQS |
250:
KLLDFCKSKD | IVLVAHSALG | TQRHKLWVDP | NSPVLLEDPV | LCALAKKHKQ |
300:
TPALIALRYQ | LQRGVVVLAK | SYNEQRIREN | IQVFEFQLTS | EDMKVLDGLN |
323:
RNYRYVVMDF | LMDHPDYPFS | DEY
Vaild Sequence:
Related Databases
Uniprot: