Gene name:
ALDH4A1 (ALDH4;P5CDH) ;
Protein name:
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) ;
Alternative:
L-glutamate gamma-semialdehyde dehydrogenase ;Aldehyde dehydrogenase family 4 member A1 ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.
Subcellular Location:
Mitochondrion matrix
Protein Attributes:
50:
MLLPAPALRR | ALLSRPWTGA | GLRWKHTSSL | KVANEPVLAF | TQGSPERDAL |
100:
QKALKDLKGR | MEAIPCVVGD | EEVWTSDVQY | QVSPFNHGHK | VAKFCYADKS |
150:
LLNKAIEAAL | AARKEWDLKP | IADRAQIFLK | AADMLSGPRR | AEILAKTMVG |
200:
QGKTVIQAEI | DAAAELIDFF | RFNAKYAVEL | EGQQPISVPP | STNSTVYRGL |
250:
EGFVAAISPF | NFTAIGGNLA | GAPALMGNVV | LWKPSDTAML | ASYAVYRILR |
300:
EAGLPPNIIQ | FVPADGPLFG | DTVTSSEHLC | GINFTGSVPT | FKHLWKQVAQ |
350:
NLDRFHTFPR | LAGECGGKNF | HFVHRSADVE | SVVSGTLRSA | FEYGGQKCSA |
400:
CSRLYVPHSL | WPQIKGRLLE | EHSRIKVGDP | AEDFGTFFSA | VIDAKSFARI |
450:
KKWLEHARSS | PSLTILAGGK | CDDSVGYFVE | PCIVESKDPQ | EPIMKEEIFG |
500:
PVLSVYVYPD | DKYKETLQLV | DSTTSYGLTG | AVFSQDKDVV | QEATKVLRNA |
550:
AGNFYINDKS | TGSIVGQQPF | GGARASGTND | KPGGPHYILR | WTSPQVIKET |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Bovine
Rat
ELISA Kit for Human P5C dehydrogenase
ELISA Kit for Human P5C dehydrogenase
ELISA Kit for Human P5C dehydrogenase
ELISA Kit for Human P5C dehydrogenase
CLIA Kit for Human P5C dehydrogenase
CLIA Kit for Human P5C dehydrogenase
CLIA Kit for Human P5C dehydrogenase
CLIA Kit for Human P5C dehydrogenase
Polyclonal Antibody for Human P5C dehydrogenase
Polyclonal Antibody for Human P5C dehydrogenase
Polyclonal Antibody for Human P5C dehydrogenase
Polyclonal Antibody for Human P5C dehydrogenase
Monoclonal Antibody for Human P5C dehydrogenase
Monoclonal Antibody for Human P5C dehydrogenase
Monoclonal Antibody for Human P5C dehydrogenase
Monoclonal Antibody for Human P5C dehydrogenase
Protein for Human P5C dehydrogenase
Protein for Human P5C dehydrogenase
Protein for Human P5C dehydrogenase
Protein for Human P5C dehydrogenase
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Kidney .
tissue :
Retina .
2.
"A novel transcript variant of human ALDH4A1 gene."
Stagos D.
,
Vasiliou V.
Submitted (2008-11) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
3.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT ILE-470
tissue :
Amygdala .
tissue :
Hippocampus .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Adipose tissue .
5.
"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G.
,
Barlow K.F.
,
McLay K.E.
,
Kaul R.
,
Swarbreck D.
,
Dunham A.
,
Scott C.E.
,
Howe K.L.
,
Woodfine K.
,
Spencer C.C.A.
,
Jones M.C.
,
Gillson C.
,
Searle S.
,
Zhou Y.
,
Kokocinski F.
,
McDonald L.
,
Evans R.
,
Phillips K.
,
Atkinson A.
,
Cooper R.
,
Jones C.
,
Hall R.E.
,
Andrews T.D.
,
Lloyd C.
,
Ainscough R.
,
Almeida J.P.
,
Ambrose K.D.
,
Anderson F.
,
Andrew R.W.
,
Ashwell R.I.S.
,
Aubin K.
,
Babbage A.K.
,
Bagguley C.L.
,
Bailey J.
,
Beasley H.
,
Bethel G.
,
Bird C.P.
,
Bray-Allen S.
,
Brown J.Y.
,
Brown A.J.
,
Buckley D.
,
Burton J.
,
Bye J.
,
Carder C.
,
Chapman J.C.
,
Clark S.Y.
,
Clarke G.
,
Clee C.
,
Cobley V.
,
Collier R.E.
,
Corby N.
,
Coville G.J.
,
Davies J.
,
Deadman R.
,
Dunn M.
,
Earthrowl M.
,
Ellington A.G.
,
Errington H.
,
Frankish A.
,
Frankland J.
,
French L.
,
Garner P.
,
Garnett J.
,
Gay L.
,
Ghori M.R.J.
,
Gibson R.
,
Gilby L.M.
,
Gillett W.
,
Glithero R.J.
,
Grafham D.V.
,
Griffiths C.
,
Griffiths-Jones S.
,
Grocock R.
,
Hammond S.
,
Harrison E.S.I.
,
Hart E.
,
Haugen E.
,
Heath P.D.
,
Holmes S.
,
Holt K.
,
Howden P.J.
,
Hunt A.R.
,
Hunt S.E.
,
Hunter G.
,
Isherwood J.
,
James R.
,
Johnson C.
,
Johnson D.
,
Joy A.
,
Kay M.
,
Kershaw J.K.
,
Kibukawa M.
,
Kimberley A.M.
,
King A.
,
Knights A.J.
,
Lad H.
,
Laird G.
,
Lawlor S.
,
Leongamornlert D.A.
,
Lloyd D.M.
,
Loveland J.
,
Lovell J.
,
Lush M.J.
,
Lyne R.
,
Martin S.
,
Mashreghi-Mohammadi M.
,
Matthews L.
,
Matthews N.S.W.
,
McLaren S.
,
Milne S.
,
Mistry S.
,
Moore M.J.F.
,
Nickerson T.
,
O'Dell C.N.
,
Oliver K.
,
Palmeiri A.
,
Palmer S.A.
,
Parker A.
,
Patel D.
,
Pearce A.V.
,
Peck A.I.
,
Pelan S.
,
Phelps K.
,
Phillimore B.J.
,
Plumb R.
,
Rajan J.
,
Raymond C.
,
Rouse G.
,
Saenphimmachak C.
,
Sehra H.K.
,
Sheridan E.
,
Shownkeen R.
,
Sims S.
,
Skuce C.D.
,
Smith M.
,
Steward C.
,
Subramanian S.
,
Sycamore N.
,
Tracey A.
,
Tromans A.
,
Van Helmond Z.
,
Wall M.
,
Wallis J.M.
,
White S.
,
Whitehead S.L.
,
Wilkinson J.E.
,
Willey D.L.
,
Williams H.
,
Wilming L.
,
Wray P.W.
,
Wu Z.
,
Coulson A.
,
Vaudin M.
,
Sulston J.E.
,
Durbin R.M.
,
Hubbard T.
,
Wooster R.
,
Dunham I.
,
Carter N.P.
,
McVean G.
,
Ross M.T.
,
Harrow J.
,
Olson M.V.
,
Beck S.
,
Rogers J.
,
Bentley D.R.
more...
Nature441:315-321(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ILE-470
tissue :
Lung .
tissue :
Placenta .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PARTIAL PROTEIN SEQUENCE
tissue :
Liver .
9.
"Human liver protein map: a reference database established by microsequencing and gel comparison."
Hochstrasser D.F.
,
Frutiger S.
,
Paquet N.
,
Bairoch A.
,
Ravier F.
,
Pasquali C.
,
Sanchez J.-C.
,
Tissot J.-D.
,
Bjellqvist B.
,
Vargas R.
,
Appel R.D.
,
Hughes G.J.
Electrophoresis13:992-1001(1992)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 25-35
tissue :
Liver .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 94-99; 105-113; 125-139; 176-191; 251-273; 339-347; 354-365 AND 510-526
tissue :
Liver .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 18-563 OF WILD-TYPE; MUTANT ALA-352 AND VARIANT HP-2 LEU-352;CATALYTIC ACTIVITY;FUNCTION;PATHWAY;BIOPHYSICOCHEMICAL PROPERTIES;SUBUNIT;ACTIVE SITE;CHARACTERIZATION OF VARIANT HP-2 LEU-352;MUTAGENESIS OF SER-352
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT HP-2 LEU-352;VARIANT LEU-16