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Index > Protein center > ALDH4A1(Gene name) > Human
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  • ALDH4A1 (Gene name),
  • Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (Protein name ),  AL4A1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ALDH4A1(ALDH4;P5CDH);
    Protein name:
    Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial(P5C dehydrogenase);
    Alternative:
    Aldehyde dehydrogenase family 4 member A1;L-glutamate gamma-semialdehyde dehydrogenase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes.
    Subcellular Location:
    Mitochondrion matrix
    Protein Attributes:
    Sequence length:
    563
    Sequence:
    50:
    MLLPAPALRR | ALLSRPWTGA | GLRWKHTSSL | KVANEPVLAF | TQGSPERDAL | 
    100:
    QKALKDLKGR | MEAIPCVVGD | EEVWTSDVQY | QVSPFNHGHK | VAKFCYADKS | 
    150:
    LLNKAIEAAL | AARKEWDLKP | IADRAQIFLK | AADMLSGPRR | AEILAKTMVG | 
    200:
    QGKTVIQAEI | DAAAELIDFF | RFNAKYAVEL | EGQQPISVPP | STNSTVYRGL | 
    250:
    EGFVAAISPF | NFTAIGGNLA | GAPALMGNVV | LWKPSDTAML | ASYAVYRILR | 
    300:
    EAGLPPNIIQ | FVPADGPLFG | DTVTSSEHLC | GINFTGSVPT | FKHLWKQVAQ | 
    350:
    NLDRFHTFPR | LAGECGGKNF | HFVHRSADVE | SVVSGTLRSA | FEYGGQKCSA | 
    400:
    CSRLYVPHSL | WPQIKGRLLE | EHSRIKVGDP | AEDFGTFFSA | VIDAKSFARI | 
    450:
    KKWLEHARSS | PSLTILAGGK | CDDSVGYFVE | PCIVESKDPQ | EPIMKEEIFG | 
    500:
    PVLSVYVYPD | DKYKETLQLV | DSTTSYGLTG | AVFSQDKDVV | QEATKVLRNA | 
    550:
    AGNFYINDKS | TGSIVGQQPF | GGARASGTND | KPGGPHYILR | WTSPQVIKET | 
    563:
    HKPLGDWSYA | YMQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    MIM:
    String:
    Pfam:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human P5C dehydrogenase
    Cat.:
    E15026m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human P5C dehydrogenase
    Cat.:
    E15026h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human P5C dehydrogenase
    MSDS:
    Please sign in first.
    ELISA Kit for Human P5C dehydrogenase
    MSDS:
    Please sign in first.
    CLIA Kit for Human P5C dehydrogenase
    MSDS:
    Please sign in first.
    CLIA Kit for Human P5C dehydrogenase
    MSDS:
    Please sign in first.
    CLIA Kit for Human P5C dehydrogenase
    Cat.:
    U15026h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human P5C dehydrogenase
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Human P5C dehydrogenase
    Polyclonal Antibody for Human P5C dehydrogenase
    Polyclonal Antibody for Human P5C dehydrogenase
    Polyclonal Antibody for Human P5C dehydrogenase
    Monoclonal Antibody for Human P5C dehydrogenase
    Monoclonal Antibody for Human P5C dehydrogenase
    Monoclonal Antibody for Human P5C dehydrogenase
    Monoclonal Antibody for Human P5C dehydrogenase
    Protein for Human P5C dehydrogenase
    Protein for Human P5C dehydrogenase
    Protein for Human P5C dehydrogenase
    Protein for Human P5C dehydrogenase

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    Precision
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    Linearity
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    References
    1. 1.
      "Cloning, characterization, and expression of cDNAs encoding human delta 1-pyrroline-5-carboxylate dehydrogenase."
      Hu C.-A. , Lin W.-W. , Valle D.
      J. Biol. Chem.271:9795-9800(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Kidney.
      tissue: Retina.
    2. 2.
      "A novel transcript variant of human ALDH4A1 gene."
      Stagos D. , Vasiliou V.
      Submitted (2008-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT ILE-470
      tissue: Amygdala.
      tissue: Hippocampus.
    4. 4.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Adipose tissue.
    5. 5.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ILE-470
      tissue: Lung.
      tissue: Placenta.
    8. 8.
      "Human liver glutamic gamma-semialdehyde dehydrogenase: structural relationship to the yeast enzyme."
      Hempel J. , Eckey R. , Berie D. , Romovacek H. , Agarwal D.P. , Goedde H.W.
      Comp. Biochem. Physiol.102B:791-793(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE
      tissue: Liver.
    9. 9.
      "Human liver protein map: a reference database established by microsequencing and gel comparison."
      Hochstrasser D.F. , Frutiger S. , Paquet N. , Bairoch A. , Ravier F. , Pasquali C. , Sanchez J.-C. , Tissot J.-D. , Bjellqvist B. , Vargas R. , Appel R.D. , Hughes G.J.
      Electrophoresis13:992-1001(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-35
      tissue: Liver.
    10. 10.
      "Human liver high Km aldehyde dehydrogenase (ALDH4): properties and structural relationship to the glutamic gamma-semialdehyde dehydrogenase."
      Agarwal D.P. , Eckey R. , Hempel J. , Goedde H.W.
      Adv. Exp. Med. Biol.328:191-197(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 94-99; 105-113; 125-139; 176-191; 251-273; 339-347; 354-365 AND 510-526
      tissue: Liver.
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      "The three-dimensional structural basis of type II hyperprolinemia."
      Srivastava D. , Singh R.K. , Moxley M.A. , Henzl M.T. , Becker D.F. , Tanner J.J.
      J. Mol. Biol.420:176-189(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 18-563 OF WILD-TYPE; MUTANT ALA-352 AND VARIANT HP-2 LEU-352;CATALYTIC ACTIVITY;FUNCTION;PATHWAY;BIOPHYSICOCHEMICAL PROPERTIES;SUBUNIT;ACTIVE SITE;CHARACTERIZATION OF VARIANT HP-2 LEU-352;MUTAGENESIS OF SER-352
    13. 13.
      "Mutations in the Delta1-pyrroline 5-carboxylate dehydrogenase gene cause type II hyperprolinemia."
      Geraghty M.T. , Vaughn D. , Nicholson A.J. , Lin W.-W. , Jimenez-Sanchez G. , Obie C. , Flynn M.P. , Valle D. , Hu C.-A.A.
      Hum. Mol. Genet.7:1411-1415(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HP-2 LEU-352;VARIANT LEU-16
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