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Index > Protein center > NPPB(Gene name) > Human
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  • NPPB (Gene name),
  • Natriuretic peptides B (Protein name ),  ANFB_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
  • |
  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (2)
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  • Gene name:
    NPPB;
    Protein name:
    Natriuretic peptides B;
    Alternative:
    Gamma-brain natriuretic peptide;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    134
    Sequence:
    50:
    MDPQTAPSRA | LLLLLFLHLA | FLGGRSHPLG | SPGSASDLET | SGLQEQRNHL | 
    100:
    QGKLSELQVE | QTSLEPLQES | PRPTGVWKSR | EVATEGIRGH | RKMVLYTLRA | 
    134:
    PRSPKMVQGS | GCFGRKMDRI | SSSSGLGCKV | LRRH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    MIM:
    SMR:
    Pfam:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Natriuretic peptides B
    Cat.:
    E0541h
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    96T
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    ELISA Kit for Human Natriuretic peptides B
    Cat.:
    E0541r
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    96T
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    ELISA Kit for Human Natriuretic peptides B
    Cat.:
    E0541d
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    96T
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    ELISA Kit for Human Natriuretic peptides B
    Cat.:
    E0541p
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    Packing:
    96T
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    ELISA Kit for Human Natriuretic peptides B
    Cat.:
    E0541m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Natriuretic peptides B
    Cat.:
    E0541b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Natriuretic peptides B
    Cat.:
    U0541m
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    MSDS:
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    Packing:
    96T
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    CLIA Kit for Human Natriuretic peptides B
    Cat.:
    U0541b
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Natriuretic peptides B
    Cat.:
    U0541r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Natriuretic peptides B
    Cat.:
    U0541p
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Natriuretic peptides B
    Cat.:
    U0541d
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human Natriuretic peptides B
    Cat.:
    U0541h
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    MSDS:
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    Packing:
    96T
    Range:
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    Polyclonal Antibody for Human Natriuretic peptides B
    Polyclonal Antibody for Human Natriuretic peptides B
    Cat.:
    P0541Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Natriuretic peptides B
    Cat.:
    P0541Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Natriuretic peptides B
    Polyclonal Antibody for Human Natriuretic peptides B
    Cat.:
    P0541Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Natriuretic peptides B
    Monoclonal Antibody for Human Natriuretic peptides B
    Monoclonal Antibody for Human Natriuretic peptides B
    Monoclonal Antibody for Human Natriuretic peptides B
    Monoclonal Antibody for Human Natriuretic peptides B
    Monoclonal Antibody for Human Natriuretic peptides B
    Monoclonal Antibody for Human Natriuretic peptides B
    Protein for Human Natriuretic peptides B
    Cat.:
    R0541h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human Natriuretic peptides B
    Protein for Human Natriuretic peptides B
    Protein for Human Natriuretic peptides B
    Protein for Human Natriuretic peptides B
    Protein for Human Natriuretic peptides B

    R&D Technical Data

    12% SDS-PAGE analysis

         12% SDS-PAGE analysis


    wb

        Western blot - Anti-BNP antibody

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Cloning and sequence analysis of cDNA encoding a precursor for human brain natriuretic peptide."
      Sudoh T. , Maekawa K. , Kojima M. , Minamino N. , Kangawa K. , Matsuo H.
      Biochem. Biophys. Res. Commun.159:1427-1434(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Silver Project."
      Kitano T. , Kobayakawa H. , Saitou N.
      Submitted (2000-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      NHLBI resequencing and genotyping service (RS&G)
      Submitted (2007-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Pancreas.
      tissue: Spleen.
    9. 9.
      "Isolation and identification of human brain natriuretic peptides in cardiac atrium."
      Hino J. , Tateyaa H. , Minamino N. , Kangawa K. , Matsuo H.
      Biochem. Biophys. Res. Commun.167:693-700(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-58 AND 103-134
    10. 10.
      "Isolation and sequence determination of human brain natriuretic peptide in human atrium."
      Kambayashi Y. , Nakao K. , Mukoyama M. , Saito Y. , Ogawa Y. , Shiono S. , Inouye K. , Yoshida N. , Imura H.
      FEBS Lett.259:341-345(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 103-134
    11. 11.
      "Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP)."
      Koller K.J. , Lowe D.G. , Bennett G.L. , Minamino N. , Kangawa K. , Matsuo H. , Goeddel D.V.
      Science252:120-123(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 12.
      "The precursor to B-type natriuretic peptide is an O-linked glycoprotein."
      Schellenberger U. , O'Rear J. , Guzzetta A. , Jue R.A. , Protter A.A. , Pollitt N.S.
      Arch. Biochem. Biophys.451:160-166(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT THR-62; SER-63; SER-70; THR-74; SER-79; THR-84 AND THR-97
    13. 13.
      "Detection of endogenous B-type natriuretic peptide at very low concentrations in patients with heart failure."
      Niederkofler E.E. , Kiernan U.A. , O'Rear J. , Menon S. , Saghir S. , Protter A.A. , Nelson R.W. , Schellenberger U.
      Circ. Heart Fail.1:258-264(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING;IDENTIFICATION BY MASS SPECTROMETRY
    14. 14.
      "Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-alpha."
      Keane F.M. , Nadvi N.A. , Yao T.W. , Gorrell M.D.
      FEBS J.278:1316-1332(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE BY FAP;CLEAVAGE SITE
    15. 15.
      "Structural determinants of natriuretic peptide receptor specificity and degeneracy."
      He X.-L. , Dukkipati A. , Garcia K.C.
      J. Mol. Biol.361:698-714(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 111-131 IN COMPLEX WITH NPR3;DISULFIDE BOND
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