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Index > Protein center > ANXA1(Gene name) > Human
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  • ANXA1 (Gene name),
  • Annexin A1 (Protein name ),  ANXA1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ANXA1(ANX1;LPC1);
    Protein name:
    Annexin A1;
    Alternative:
    Lipocortin I;Chromobindin-9;Calpactin-2;Calpactin II;p35;Phospholipase A2 inhibitory protein;Annexin I;Annexin-1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF.
    Function:
    Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.
    Subcellular Location:
    Nucleus Cytoplasm Cell projection cilium Basolateral cell membrane Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and alveolar macrophages.
    Protein Attributes:
    Sequence length:
    346
    Sequence:
    50:
    MAMVSEFLKQ | AWFIENEEQE | YVQTVKSSKG | GPGSAVSPYP | TFNPSSDVAA | 
    100:
    LHKAIMVKGV | DEATIIDILT | KRNNAQRQQI | KAAYLQETGK | PLDETLKKAL | 
    150:
    TGHLEEVVLA | LLKTPAQFDA | DELRAAMKGL | GTDEDTLIEI | LASRTNKEIR | 
    200:
    DINRVYREEL | KRDLAKDITS | DTSGDFRNAL | LSLAKGDRSE | DFGVNEDLAD | 
    250:
    SDARALYEAG | ERRKGTDVNV | FNTILTTRSY | PQLRRVFQKY | TKYSKHDMNK | 
    300:
    VLDLELKGDI | EKCLTAIVKC | ATSKPAFFAE | KLHQAMKGVG | TRHKALIRIM | 
    346:
    VSRSEIDMND | IKAFYQKMYG | ISLCQAILDE | TKGDYEKILV | ALCGGN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    MIM:
    String:
    SMR:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Annexin A1
    Cat.:
    E0333h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Annexin A1
    Cat.:
    E0333p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Annexin A1
    Cat.:
    E0333r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Annexin A1
    Cat.:
    E0333m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Annexin A1
    MSDS:
    Please sign in first.
    ELISA Kit for Human Annexin A1
    Cat.:
    E0333c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Annexin A1
    Cat.:
    E0333b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Annexin A1
    Cat.:
    U0333m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Annexin A1
    Cat.:
    U0333p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Annexin A1
    Cat.:
    U0333r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Annexin A1
    Cat.:
    U0333c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Annexin A1
    Cat.:
    U0333b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Annexin A1
    MSDS:
    Please sign in first.
    CLIA Kit for Human Annexin A1
    Cat.:
    U0333h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Annexin A1
    Polyclonal Antibody for Human Annexin A1
    Cat.:
    P0333Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Annexin A1
    Cat.:
    P0333Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Annexin A1
    Cat.:
    P0333Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Annexin A1
    Polyclonal Antibody for Human Annexin A1
    Polyclonal Antibody for Human Annexin A1
    Monoclonal Antibody for Human Annexin A1
    Monoclonal Antibody for Human Annexin A1
    Monoclonal Antibody for Human Annexin A1
    Monoclonal Antibody for Human Annexin A1
    Monoclonal Antibody for Human Annexin A1
    Monoclonal Antibody for Human Annexin A1
    Monoclonal Antibody for Human Annexin A1
    Protein for Human Annexin A1
    Protein for Human Annexin A1
    Protein for Human Annexin A1
    Protein for Human Annexin A1
    Protein for Human Annexin A1
    Protein for Human Annexin A1
    Protein for Human Annexin A1

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    References
    1. 1.
      "Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity."
      Wallner B.P. , Mattaliano R.J. , Hession C. , Cate R.L. , Tizard R. , Sinclair L.K. , Foeller C. , Chow E.P. , Browning J.L. , Ramachandran K.L. , Pepinsky R.B.
      Nature320:77-81(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Correlation of gene and protein structure of rat and human lipocortin I."
      Kovacic R.T. , Tizard R. , Cate R.L. , Frey A.Z. , Wallner B.P.
      Biochemistry30:9015-9021(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli."
      Arcone R. , Arpaia G. , Ruoppolo M. , Malorni A. , Pucci P. , Marino G. , Ialenti A. , di Rosa M. , Ciliberto G.
      Eur. J. Biochem.211:347-355(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Cervix.
      tissue: Lung.
    5. 5.
      "Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C."
      Varticovski L. , Chahwala S.B. , Whitman M. , Cantley L. , Schindler D. , Chow E.P. , Sinclair L.K. , Pepinsky R.B.
      Biochemistry27:3682-3690(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;PHOSPHORYLATION AT TYR-21 BY EGFR AND SER-27 BY PKC
    6. 6.
      "Characterization by tandem mass spectrometry of structural modifications in proteins."
      Biemann K. , Scoble H.A.
      Science237:992-998(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
    7. 7.
      "A dimeric form of lipocortin-1 in human placenta."
      Pepinsky R.B. , Sinclair L.K. , Chow E.P. , O'Brine-Greco B.
      Biochem. J.263:97-103(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DIMERIZATION
    8. 8.
      "Phosphorylation of annexin I by TRPM7 channel-kinase."
      Dorovkov M.V. , Ryazanov A.G.
      J. Biol. Chem.279:50643-50646(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-5 BY TRPM7
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-239 AND LYS-312;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "Crystal structure of human annexin I at 2.5-A resolution."
      Weng X. , Luecke H. , Song I.S. , Kang D.S. , Kim S.-H. , Huber R.
      Protein Sci.2:448-458(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)
    14. 14.
      "NMR solution structure of domain 1 of human annexin I shows an autonomous folding unit."
      Gao J. , Li Y. , Yan H.
      J. Biol. Chem.274:2971-2977(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 41-113
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