Gene name:
ANXA2 (ANX2;ANX2L4;CAL1H;LPC2D) ;
Protein name:
Annexin A2 ;
Alternative:
Annexin-2 ;Annexin II ;Calpactin-1 heavy chain ;Calpactin I heavy chain ;Lipocortin II ;Chromobindin-8 ;Protein I ;Placental anticoagulant protein IV (PAP-IV) ;p36 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF (By similarity). Interacts with human cytomegalovirus (HCMV).
Function:
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
basement membrane
Melanosome
In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.
Protein Attributes:
50:
MSTVHEILCK | LSLEGDHSTP | PSAYGSVKAY | TNFDAERDAL | NIETAIKTKG |
100:
VDEVTIVNIL | TNRSNAQRQD | IAFAYQRRTK | KELASALKSA | LSGHLETVIL |
150:
GLLKTPAQYD | ASELKASMKG | LGTDEDSLIE | IICSRTNQEL | QEINRVYKEM |
200:
YKTDLEKDII | SDTSGDFRKL | MVALAKGRRA | EDGSVIDYEL | IDQDARDLYD |
250:
AGVKRKGTDV | PKWISIMTER | SVPHLQKVFD | RYKSYSPYDM | LESIRKEVKG |
300:
DLENAFLNLV | QCIQNKPLYF | ADRLYDSMKG | KGTRDKVLIR | IMVSRSEVDM |
339:
LKIRSEFKRK | YGKSLYYYIQ | QDTKGDYQKA | LLYLCGGDD
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Dog
Pig
Mouse
Chicken
Bovine
ELISA Kit for Human Annexin A2
ELISA Kit for Human Annexin A2
ELISA Kit for Human Annexin A2
ELISA Kit for Human Annexin A2
ELISA Kit for Human Annexin A2
ELISA Kit for Human Annexin A2
ELISA Kit for Human Annexin A2
CLIA Kit for Human Annexin A2
CLIA Kit for Human Annexin A2
CLIA Kit for Human Annexin A2
CLIA Kit for Human Annexin A2
CLIA Kit for Human Annexin A2
CLIA Kit for Human Annexin A2
CLIA Kit for Human Annexin A2
Polyclonal Antibody for Human Annexin A2
Polyclonal Antibody for Human Annexin A2
Polyclonal Antibody for Human Annexin A2
Polyclonal Antibody for Human Annexin A2
Polyclonal Antibody for Human Annexin A2
Polyclonal Antibody for Human Annexin A2
Polyclonal Antibody for Human Annexin A2
Monoclonal Antibody for Human Annexin A2
Monoclonal Antibody for Human Annexin A2
Monoclonal Antibody for Human Annexin A2
Monoclonal Antibody for Human Annexin A2
Monoclonal Antibody for Human Annexin A2
Monoclonal Antibody for Human Annexin A2
Monoclonal Antibody for Human Annexin A2
Protein for Human Annexin A2
Protein for Human Annexin A2
Protein for Human Annexin A2
Protein for Human Annexin A2
Protein for Human Annexin A2
Protein for Human Annexin A2
Protein for Human Annexin A2
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Shetty P, Patil V S, Mohan R, et al.
References
1.
"Two human 35 kd inhibitors of phospholipase A2 are related to substrates of pp60v-src and of the epidermal growth factor receptor/kinase."
Huang K.-S.
,
Wallner B.P.
,
Mattaliano R.J.
,
Tizard R.
,
Burne C.
,
Frey A.
,
Hession C.
,
McGray P.
,
Sinclair L.K.
,
Chow E.P.
,
Browning J.L.
,
Ramachandran K.L.
,
Tang J.
,
Smart J.E.
,
Pepinsky R.B.
Cell46:191-199(1986)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Placenta .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N.
,
Chen X.
,
Rolfs A.
,
Halleck A.
,
Hines L.
,
Eisenstein S.
,
Koundinya M.
,
Raphael J.
,
Moreira D.
,
Kelley T.
,
LaBaer J.
,
Lin Y.
,
Phelan M.
,
Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
4.
"The full-ORF clone resource of the German cDNA consortium."
Bechtel S.
,
Rosenfelder H.
,
Duda A.
,
Schmidt C.P.
,
Ernst U.
,
Wellenreuther R.
,
Mehrle A.
,
Schuster C.
,
Bahr A.
,
Bloecker H.
,
Heubner D.
,
Hoerlein A.
,
Michel G.
,
Wedler H.
,
Koehrer K.
,
Ottenwaelder B.
,
Poustka A.
,
Wiemann S.
,
Schupp I.
more...
BMC Genomics8:399-399(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Colon endothelium .
5.
"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C.
,
Garber M.
,
Sharpe T.
,
Young S.K.
,
Rowen L.
,
O'Neill K.
,
Whittaker C.A.
,
Kamal M.
,
Chang J.L.
,
Cuomo C.A.
,
Dewar K.
,
FitzGerald M.G.
,
Kodira C.D.
,
Madan A.
,
Qin S.
,
Yang X.
,
Abbasi N.
,
Abouelleil A.
,
Arachchi H.M.
,
Baradarani L.
,
Birditt B.
,
Bloom S.
,
Bloom T.
,
Borowsky M.L.
,
Burke J.
,
Butler J.
,
Cook A.
,
DeArellano K.
,
DeCaprio D.
,
Dorris L. III
,
Dors M.
,
Eichler E.E.
,
Engels R.
,
Fahey J.
,
Fleetwood P.
,
Friedman C.
,
Gearin G.
,
Hall J.L.
,
Hensley G.
,
Johnson E.
,
Jones C.
,
Kamat A.
,
Kaur A.
,
Locke D.P.
,
Madan A.
,
Munson G.
,
Jaffe D.B.
,
Lui A.
,
Macdonald P.
,
Mauceli E.
,
Naylor J.W.
,
Nesbitt R.
,
Nicol R.
,
O'Leary S.B.
,
Ratcliffe A.
,
Rounsley S.
,
She X.
,
Sneddon K.M.B.
,
Stewart S.
,
Sougnez C.
,
Stone S.M.
,
Topham K.
,
Vincent D.
,
Wang S.
,
Zimmer A.R.
,
Birren B.W.
,
Hood L.
,
Lander E.S.
,
Nusbaum C.
more...
Nature440:671-675(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT LEU-98
tissue :
Brain .
tissue :
Colon .
tissue :
Pancreas .
tissue :
Prostate .
tissue :
Skin .
tissue :
Testis .
tissue :
Urinary bladder .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 2-10; 38-47; 50-63; 69-77; 89-115; 153-169 AND 213-220;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Colon adenocarcinoma .
tissue :
Osteosarcoma .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 11-27; 49-62; 68-77; 120-135; 314-323 AND 329-339
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 15-40 AND 50-63
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 18-37; 119-126; 172-191 AND 301-307;INTERACTION WITH HCMV
tissue :
Umbilical vein endothelial cell .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 234-241 AND 252-261
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-26
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-24;MUTAGENESIS OF TYR-24
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ISGYLATION
15.
"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
Chi A.
,
Valencia J.C.
,
Hu Z.-Z.
,
Watabe H.
,
Yamaguchi H.
,
Mangini N.J.
,
Huang H.
,
Canfield V.A.
,
Cheng K.C.
,
Yang F.
,
Abe R.
,
Yamagishi S.
,
Shabanowitz J.
,
Hearing V.J.
,
Wu C.
,
Appella E.
,
Hunt D.F.
J. Proteome Res.5:3135-3144(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
tissue :
Melanoma .
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH COCH
18.
"The crystal structure and ion channel activity of human annexin II, a peripheral membrane protein."
Burger A.
,
Berendes R.
,
Liemann S.
,
Benz J.
,
Hofmann A.
,
Goettig P.
,
Huber R.
,
Gerke V.
,
Tiel C.
,
Roemisch J.
,
Weber K.
J. Mol. Biol.257:839-847(1996)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS)