AOX1 ELISA Kit for Human(Homo sapiens) | EIAab.comAOX1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > AOX1(Gene name) > Human

AOX1 (Gene name),

Aldehyde oxidase (Protein name ), AOXA_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

AOX1(AO);

Protein name:

Aldehyde oxidase;

Alternative:

1.17.3.-;Azaheterocycle hydroxylase);Aldehyde oxidase 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer.

Function:

Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N-methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

1338

Sequence:

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1150:

1200:

1250:

1300:

1338:

TLNSPLTPEK | IRMACEDKFT | KMIPRDEPGS | YVPWNVPI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.406238

Pfam:

PF01315

KEGG:

hsa:316

MIM:

602841

STRING:

9606.ENSP00000363832

SMR:

Q06278

Uniprot:

Q06278

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ELISA Kit for Human Aldehyde oxidase

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E5988m

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96T

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ELISA Kit for Human Aldehyde oxidase

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ELISA Kit for Human Aldehyde oxidase

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E5988r

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96T

ELISA Kit for Human Aldehyde oxidase

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E5988b

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96T

ELISA Kit for Human Aldehyde oxidase

Cat.:

E5988h

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96T

CLIA Kit for Human Aldehyde oxidase

Cat.:

U5988r

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96T

CLIA Kit for Human Aldehyde oxidase

Cat.:

U5988m

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MSDS:

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Packing:

96T

CLIA Kit for Human Aldehyde oxidase

Cat.:

U5988b

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Packing:

96T

CLIA Kit for Human Aldehyde oxidase

MSDS:

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CLIA Kit for Human Aldehyde oxidase

Cat.:

U5988h

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96T

Polyclonal Antibody for Human Aldehyde oxidase

Cat.:

P5988Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Aldehyde oxidase

Cat.:

P5988Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Aldehyde oxidase

Monoclonal Antibody for Human Aldehyde oxidase

Protein for Human Aldehyde oxidase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"cDNA cloning, characterization, and tissue-specific expression of human xanthine dehydrogenase/xanthine oxidase."
Wright R.M. , Vaitaitis G.M. , Wilson C.M. , Repine T.B. , Terada L.S. , Repine J.E.
Proc. Natl. Acad. Sci. U.S.A.90:10690-10694(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
tissue: Liver.
2.

"Molecular cloning, refined chromosomal mapping, and structural analysis of the human gene encoding aldehyde oxidase (AOX1), a candidate for the ALS2 gene."
Wright R.M. , Weigel L.K. , Varella-Garcia M. , Vaitaitis G. , Repine J.E.
Redox Rep.3:135-144(1997)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Mutation of human molybdenum cofactor sulfurase gene is responsible to classical xanthinuria type II."
Ichida K. , Matsumura T. , Sakuma R. , Hosoya T. , Nishino T.
Biochem. Biophys. Res. Commun.282:1194-1200(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Liver.
4.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Colon.
7.

"Substrate specificity of human liver aldehyde oxidase toward substituted quinazolines and phthalazines: a comparison with hepatic enzyme from guinea pig, rabbit, and baboon."
Beedham C. , Critchley D.J. , Rance D.J.
Arch. Biochem. Biophys.319:481-490(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS AZAHETEROCYCLE OXIDASE;SUBSTRATE SPECIFICITY
8.

"In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver."
Rashidi M.R. , Smith J.A. , Clarke S.E. , Beedham C.
Drug Metab. Dispos.25:805-813(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS AZAHETEROCYCLE OXIDASE;CATALYTIC ACTIVITY;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES
9.

"Aldehyde oxidase 1 is highly abundant in hepatic steatosis and is down-regulated by adiponectin and fenofibric acid in hepatocytes in vitro."
Neumeier M. , Weigert J. , Schaeffler A. , Weiss T.S. , Schmidl C. , Buettner R. , Bollheimer C. , Aslanidis C. , Schoelmerich J. , Buechler C.
Biochem. Biophys. Res. Commun.350:731-735(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
10.

"Mammalian aldehyde oxidases: genetics, evolution and biochemistry."
Garattini E. , Fratelli M. , Terao M.
Cell. Mol. Life Sci.65:1019-1048(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;NOMENCLATURE;TISSUE SPECIFICITY
11.

"Small-interference RNA-mediated knock-down of aldehyde oxidase 1 in 3T3-L1 cells impairs adipogenesis and adiponectin release."
Weigert J. , Neumeier M. , Bauer S. , Mages W. , Schnitzbauer A.A. , Obed A. , Groeschl B. , Hartmann A. , Schaeffler A. , Aslanidis C. , Schoelmerich J. , Buechler C.
FEBS Lett.582:2965-2972(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;SUBCELLULAR LOCATION
12.

"In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase."
Zientek M. , Jiang Y. , Youdim K. , Obach R.S.
Drug Metab. Dispos.38:1322-1327(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS DRUG-METABOLIZING ENZYME;SUBSTRATE SPECIFICITY;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
13.

"Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes."
Hutzler J.M. , Yang Y.S. , Albaugh D. , Fullenwider C.L. , Schmenk J. , Fisher M.B.
Drug Metab. Dispos.40:267-275(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS DRUG-METABOLIZING ENZYME;ENZYME REGULATION;SUBSTRATE SPECIFICITY;TISSUE SPECIFICITY
14.

"Hydralazine as a selective probe inactivator of aldehyde oxidase in human hepatocytes: estimation of the contribution of aldehyde oxidase to metabolic clearance."
Strelevitz T.J. , Orozco C.C. , Obach R.S.
Drug Metab. Dispos.40:1441-1448(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS DRUG-METABOLIZING ENZYME;ENZYME REGULATION;SUBSTRATE SPECIFICITY;TISSUE SPECIFICITY
15.

"The role of aldehyde oxidase in drug metabolism."
Garattini E. , Terao M.
Expert Opin. Drug Metab. Toxicol.8:487-503(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
16.

"Evidence for substrate-dependent inhibition profiles for human liver aldehyde oxidase."
Barr J.T. , Jones J.P.
Drug Metab. Dispos.41:24-29(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS AZAHETEROCYCLE OXIDASE;CATALYTIC ACTIVITY;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES
17.

"Aldehyde oxidase 1 (AOX1) in human liver cytosols: quantitative characterization of AOX1 expression level and activity relationship."
Fu C. , Di L. , Han X. , Soderstrom C. , Snyder M. , Troutman M.D. , Obach R.S. , Zhang H.
Drug Metab. Dispos.41:1797-1804(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS DRUG-METABOLIZING ENZYME;SUBSTRATE SPECIFICITY;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;IDENTIFICATION BY MASS SPECTROMETRY
18.

"The impact of single nucleotide polymorphisms on human aldehyde oxidase."
Hartmann T. , Terao M. , Garattini E. , Teutloff C. , Alfaro J.F. , Jones J.P. , Leimkuehler S.
Drug Metab. Dispos.40:856-864(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYS-802; HIS-921; SER-1135; LEU-1271 AND ARG-1297;CHARACTERIZATION OF VARIANTS CYS-802; HIS-921; SER-1135 AND ARG-1297;FUNCTION AS OXIDASE;HOMODIMER;COFACTOR;SUBSTRATE SPECIFICITY;BIOPHYSICOCHEMICAL PROPERTIES

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