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Index > Protein center > AP2B1(Gene name) > Human
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  • AP2B1 (Gene name),
  • AP-2 complex subunit beta (Protein name ),  AP2B1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    AP2B1(ADTB2;CLAPB1);
    Protein name:
    AP-2 complex subunit beta;
    Alternative:
    Clathrin assembly protein complex 2 beta large chain;Beta-adaptin;Beta-2-adaptin;Adaptor protein complex AP-2 subunit beta;Plasma membrane adaptor HA2/AP2 adaptin beta subunit;AP105B;Adapter-related protein complex 2 beta subunit;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Adaptor protein complex 2 (AP-2) is an heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). Interacts with EPN1. Interacts with EPS15; clathrin competes with EPS15. Interacts with SNAP91; clathrin competes with SNAP91. Interacts with CLTC; clathrin competes with EPS15, SNAP91 and PIP5K1C. Interacts with LDLRAP1. Interacts with AMPH and BIN1. Interacts with ARF6 (GDP-bound). Interacts (dephosphorylated at Tyr-737) with ARRB1; phosphorylation of AP2B1 at Tyr-737 disrupts the interaction. Interacts with SLC2A8. Interacts with SCYL1 and SCYL2. Interacts with TGFBR1 and TGFBR2. Interacts with PIP5K1C; clathrin competes with PIP5K1C (By similarity). Interacts with DENND1B, but not with DENND1A, nor DENND1C.
    Function:
    Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly.
    Subcellular Location:
    Cell membrane Membrane coated pit Peripheral membrane protein Cytoplasmic side AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV.
    Protein Attributes:
    Sequence length:
    937
    Sequence:
    50:
    MTDSKYFTTN | KKGEIFELKA | ELNNEKKEKR | KEAVKKVIAA | MTVGKDVSSL | 
    100:
    FPDVVNCMQT | DNLELKKLVY | LYLMNYAKSQ | PDMAIMAVNS | FVKDCEDPNP | 
    150:
    LIRALAVRTM | GCIRVDKITE | YLCEPLRKCL | KDEDPYVRKT | AAVCVAKLHD | 
    200:
    INAQMVEDQG | FLDSLRDLIA | DSNPMVVANA | VAALSEISES | HPNSNLLDLN | 
    250:
    PQNINKLLTA | LNECTEWGQI | FILDCLSNYN | PKDDREAQSI | CERVTPRLSH | 
    300:
    ANSAVVLSAV | KVLMKFLELL | PKDSDYYNML | LKKLAPPLVT | LLSGEPEVQY | 
    350:
    VALRNINLIV | QKRPEILKQE | IKVFFVKYND | PIYVKLEKLD | IMIRLASQAN | 
    400:
    IAQVLAELKE | YATEVDVDFV | RKAVRAIGRC | AIKVEQSAER | CVSTLLDLIQ | 
    450:
    TKVNYVVQEA | IVVIRDIFRK | YPNKYESIIA | TLCENLDSLD | EPDARAAMIW | 
    500:
    IVGEYAERID | NADELLESFL | EGFHDESTQV | QLTLLTAIVK | LFLKKPSETQ | 
    550:
    ELVQQVLSLA | TQDSDNPDLR | DRGYIYWRLL | STDPVTAKEV | VLSEKPLISE | 
    600:
    ETDLIEPTLL | DELICHIGSL | ASVYHKPPNA | FVEGSHGIHR | KHLPIHHGST | 
    650:
    DAGDSPVGTT | TATNLEQPQV | IPSQGDLLGD | LLNLDLGPPV | NVPQVSSMQM | 
    700:
    GAVDLLGGGL | DSLVGQSFIP | SSVPATFAPS | PTPAVVSSGL | NDLFELSTGI | 
    750:
    GMAPGGYVAP | KAVWLPAVKA | KGLEISGTFT | HRQGHIYMEM | NFTNKALQHM | 
    800:
    TDFAIQFNKN | SFGVIPSTPL | AIHTPLMPNQ | SIDVSLPLNT | LGPVMKMEPL | 
    850:
    NNLQVAVKNN | IDVFYFSCLI | PLNVLFVEDG | KMERQVFLAT | WKDIPNENEL | 
    900:
    QFQIKECHLN | ADTVSSKLQN | NNVYTIAKRN | VEGQDMLYQS | LKLTNGIWIL | 
    937:
    AELRIQPGNP | NYTLSLKCRA | PEVSQYIYQV | YDSILKN
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    String:
    KEGG:
    MIM:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human AP-2 complex subunit beta
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    E12362h
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    ELISA Kit for Human AP-2 complex subunit beta
    MSDS:
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    ELISA Kit for Human AP-2 complex subunit beta
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    E12362m
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    Packing:
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    ELISA Kit for Human AP-2 complex subunit beta
    Cat.:
    E12362r
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    Packing:
    96T
    CLIA Kit for Human AP-2 complex subunit beta
    Cat.:
    U12362m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human AP-2 complex subunit beta
    MSDS:
    Please sign in first.
    CLIA Kit for Human AP-2 complex subunit beta
    Cat.:
    U12362h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human AP-2 complex subunit beta
    Cat.:
    U12362r
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human AP-2 complex subunit beta
    Polyclonal Antibody for Human AP-2 complex subunit beta
    Polyclonal Antibody for Human AP-2 complex subunit beta
    Polyclonal Antibody for Human AP-2 complex subunit beta
    Cat.:
    P12362Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human AP-2 complex subunit beta
    Monoclonal Antibody for Human AP-2 complex subunit beta
    Monoclonal Antibody for Human AP-2 complex subunit beta
    Monoclonal Antibody for Human AP-2 complex subunit beta
    Protein for Human AP-2 complex subunit beta
    Protein for Human AP-2 complex subunit beta
    Protein for Human AP-2 complex subunit beta
    Protein for Human AP-2 complex subunit beta

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    References
    1. 1.
      "Conservation and diversity in families of coated vesicle adaptins."
      Ponnambalam S. , Robinson M.S. , Jackson A.P. , Peiperl L. , Parham P.
      J. Biol. Chem.265:4814-4820(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    2. 2.
      "Expression of a novel beta adaptin subunit mRNA splice variant in human testes."
      Zhang X.D. , Yin L.L. , Zheng Y. , Lu L. , Zhou Z.M. , Sha J.H.
      Asian J. Androl.7:179-188(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);ALTERNATIVE SPLICING
      tissue: Testis.
    3. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Muscle.
    5. 6.
      "beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binding site in beta 2-adaptin."
      Laporte S.A. , Miller W.E. , Kim K.-M. , Caron M.G.
      J. Biol. Chem.277:9247-9254(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARRB1;MUTAGENESIS OF GLU-849 AND GLU-902
    6. 7.
      "Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit."
      Yao D. , Ehrlich M. , Henis Y.I. , Leof E.B.
      Mol. Biol. Cell13:4001-4012(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TGFBR1 AND TGFBR2
    7. 8.
      "Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network."
      Nakatsu F. , Ohno H.
      Cell Struct. Funct.28:419-429(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF THE AP-2 COMPLEX IN CLATHRIN-MEDIATED ENDOCYTOSIS
    8. 9.
      "The AP-2 complex is excluded from the dynamic population of plasma membrane-associated clathrin."
      Rappoport J.Z. , Taha B.W. , Lemeer S. , Benmerah A. , Simon S.M.
      J. Biol. Chem.278:47357-47360(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    9. 10.
      "Adaptors for clathrin coats: structure and function."
      Owen D.J. , Collins B.M. , Evans P.R.
      Annu. Rev. Cell Dev. Biol.20:153-191(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF THE AP-2 COMPLEX IN CLATHRIN-MEDIATED ENDOCYTOSIS
    10. 11.
      "Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference."
      Huang F. , Khvorova A. , Marshall W. , Sorkin A.
      J. Biol. Chem.279:16657-16661(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CLATHRIN-MEDIATED ENDOCYTOSIS
    11. 12.
      "Functional dissection of an AP-2 beta2 appendage-binding sequence within the autosomal recessive hypercholesterolemia protein."
      Mishra S.K. , Keyel P.A. , Edeling M.A. , Dupin A.L. , Owen D.J. , Traub L.M.
      J. Biol. Chem.280:19270-19280(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LDLRAP1;MUTAGENESIS OF TRP-841 AND TYR-888
    12. 13.
      "Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex."
      Schmidt U. , Briese S. , Leicht K. , Schuermann A. , Joost H.-G. , Al-Hasani H.
      J. Cell Sci.119:2321-2331(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SLC2A8
    13. 14.
      "ARF6 regulates angiotensin II type 1 receptor endocytosis by controlling the recruitment of AP-2 and clathrin."
      Poupart M.-E. , Fessart D. , Cotton M. , Laporte S.A. , Claing A.
      Cell. Signal.19:2370-2378(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARF6
    14. 15.
      "Src-dependent phosphorylation of beta2-adaptin dissociates the beta-arrestin-AP-2 complex."
      Fessart D. , Simaan M. , Zimmerman B. , Comeau J. , Hamdan F.F. , Wiseman P.W. , Bouvier M. , Laporte S.A.
      J. Cell Sci.120:1723-1732(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-737;INTERACTION WITH ARRB1
    15. 16.
      "The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway."
      Lau A.W. , Chou M.M.
      J. Cell Sci.121:4008-4017(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF THE AP-2 COMPLEX IN NON-CLATHRIN-DEPENDENT ENDOCYTOSIS
    16. 17.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    17. 18.
      "c-Src-mediated phosphorylation of AP-2 reveals a general mechanism for receptors internalizing through the clathrin pathway."
      Zimmerman B. , Simaan M. , Lee M.-H. , Luttrell L.M. , Laporte S.A.
      Cell. Signal.21:103-110(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-737
    18. 19.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-265;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 20.
      "The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery."
      Marat A.L. , McPherson P.S.
      J. Biol. Chem.285:10627-10637(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DENND1B;MUTAGENESIS OF TRP-841; GLU-849; TYR-888 AND GLU-902
    20. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    21. 22.
      "Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning."
      Umasankar P.K. , Sanker S. , Thieman J.R. , Chakraborty S. , Wendland B. , Tsang M. , Traub L.M.
      Nat. Cell Biol.14:488-501(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FCHO1
    22. 23.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT THR-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    23. 24.
      "The structure and function of the beta 2-adaptin appendage domain."
      Owen D.J. , Vallis Y. , Pearse B.M.F. , McMahon H.T. , Evans P.R.
      EMBO J.19:4216-4227(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 701-937;MUTAGENESIS OF ARG-879; TYR-888 AND LYS-917;INTERACTION WITH EPN1; EPS15; SNAP91 AND CLTC
    24. 25.
      "Molecular architecture and functional model of the endocytic AP2 complex."
      Collins B.M. , McCoy A.J. , Kent H.M. , Evans P.R. , Owen D.J.
      Cell109:523-535(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.59 ANGSTROMS) OF 1-591 IN COMPLEX WITH AP2A2; AP2M1; AP2S1 AND AN INOSITOL POLYPHOSPHATE HEADGROUP
    25. 26.
      "Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly."
      Edeling M.A. , Mishra S.K. , Keyel P.A. , Steinhauser A.L. , Collins B.M. , Roth R. , Heuser J.E. , Owen D.J. , Traub L.M.
      Dev. Cell10:329-342(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 701-937 IN COMPLEX WITH LDLRAP1;INTERACTION WITH ARRB1; EPN1; SNAP91; AMPH AND BIN1;MUTAGENESIS OF TYR-815; TRP-841; GLU-849; TYR-888 AND GLU-902
    26. 27.
      "Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly."
      Schmid E.M. , Ford M.G.J. , Burtey A. , Praefcke G.J.K. , Peak-Chew S.-Y. , Mills I.G. , Benmerah A. , McMahon H.T.
      PLoS Biol.4:E262-E262(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 700-937 IN COMPLEX WITH EPS15;X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 700-937 IN COMPLEX WITH ARRB1;INTERACTION WITH SCYL1; SCYL2; EPS15; AMPH; SNAP91; ARRB1 AND LDLRAP1;MUTAGENESIS OF TYR-815; TRP-841; LYS-842; GLN-851; ARG-879 AND TYR-888
    27. 28.
      "A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex."
      Kelly B.T. , McCoy A.J. , Spaete K. , Miller S.E. , Evans P.R. , Hoening S. , Owen D.J.
      Nature456:976-979(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 1-591 IN COMPLEX WITH AP2A2; AP2M1; AP2S1 AND CD4 INTERNALIZATION SIGNAL
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