APC ELISA Kit for Human(Homo sapiens) | EIAab.comAPC ELISA Kit for Human(Homo sapiens)

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APC (Gene name),

Adenomatous polyposis coli protein (Protein name ), APC_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

APC(DP2.5);

Protein name:

Adenomatous polyposis coli protein(Protein APC);

Alternative:

Deleted in polyposis 2.5;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Forms homooligomers and heterooligomers with APC2. Interacts with DIAPH1 and DIAPH2 (By similarity). Interacts with PDZ domains of DLG1 and DLG3. Associates with catenins. Binds axin. Interacts with ARHGEF4 (via N-terminus). Interacts with MAPRE1 (via C-terminus); probably required for APC targeting to the growing microtubule plus ends. Interacts with MAPRE2 and MAPRE3 (via C-terminus). Found in a complex consisting of ARHGEF4, APC and CTNNB1. Interacts with SCRIB; may mediate APC targeting to adherens junctions of epithelial cells. Interacts with SPATA13 (via N-terminus and SH3 domain). Interacts with ASAP1 (via SH3 domain). Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B.

Function:

Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

Subcellular Location:

Cell junction adherens junction Cytoplasm cytoskeleton Cell projection lamellipodium Cell projection ruffle membrane Cytoplasm Cell membrane Associated with the microtubule network at the growing distal tip of microtubules. Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane.

Protein Attributes:

Sequence length:

2843

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2843:

RPSQIPTPVN | NNTKKRDSKT | DSTESSGTQS | PKRHSGSYLV | TSV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:324

Pfam:

PF05972

SMR:

P25054

UniGene:

Hs.158932

String:

P25054

STRING:

9606.ENSP00000257430

MIM:

114550

Uniprot:

P25054

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ELISA Kit for Human Protein APC

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E10944m

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96T

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ELISA Kit for Human Protein APC

Cat.:

E10944h

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96T

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ELISA Kit for Human Protein APC

Cat.:

E10944r

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96T

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CLIA Kit for Human Protein APC

Cat.:

U10944h

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Packing:

96T

CLIA Kit for Human Protein APC

Cat.:

U10944m

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MSDS:

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Packing:

96T

CLIA Kit for Human Protein APC

Cat.:

U10944r

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96T

Polyclonal Antibody for Human Protein APC

Cat.:

P10944Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Protein APC

Protein for Human Protein APC

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Identification of deletion mutations and three new genes at the familial polyposis locus."
Joslyn G. , Carlson M. , Thliveris A. , Albertsen H. , Gelbert L. , Samowitz W. , Groden J. , Stevens J. , Spirio L. , Robertson M. , Sargeant L. , Krapcho K. , Wolff E. , Burt R. , Hughes J.P. , Warrington J. , McPherson J.D. , Wasmuth J.J. , more...
Cell66:601-613(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT);VARIANT ASP-1822
tissue: Fetal brain.
2.

"Identification of FAP locus genes from chromosome 5q21."
Kinzler K.W. , Nilbert M.C. , Su L.-K. , Vogelstein B. , Bryan T.M. , Levy D.B. , Smith K.J. , Preisinger A.C. , Hedge P. , McKechnie D. , Finniear R. , Markham A. , Groffen J. , Boguski M.S. , Altschul S.F. , Horii A.K. , Ando H. , Miyoshi Y. , more...
Science253:661-665(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG);VARIANT ASP-1822
3.

"Asef, a link between the tumor suppressor APC and G-protein signaling."
Kawasaki Y. , Senda T. , Ishidate T. , Koyama R. , Morishita T. , Iwayama Y. , Higuchi O. , Akiyama T.
Science289:1194-1197(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG);FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH ARHGEF4;IDENTIFICATION IN A COMPLEX WITH ARHGEF4 AND CTNNB1
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ASP-1822
5.

"Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer."
Miki Y. , Nishisho I. , Horii A. , Miyoshi Y. , Utsunomiya J. , Kinzler K.W. , Vogelstein B. , Nakamura Y.
Cancer Res.52:643-645(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1506-1524
6.

"Association of the APC tumor suppressor protein with catenins."
Su L.-K. , Vogelstein B. , Kinzler K.W.
Science262:1734-1737(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH CATENINS
7.

"Hereditary desmoid disease due to a frameshift mutation at codon 1924 of the APC gene."
Eccles D.M. , van der Luijt R.B. , Breukel C. , Bullman H. , Bunyan D. , Fisher A. , Barber J. , du Boulay C. , Primrose J. , Burn J. , Fodde R.
Am. J. Hum. Genet.59:1193-1201(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN HEREDITARY DESMOID DISEASE
8.

"Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein."
Matsumine A. , Ogai A. , Senda T. , Okumura N. , Satoh K. , Baeg G.-H. , Kawahara T. , Kobayashi S. , Okada M. , Toyoshima K. , Akiyama T.
Science272:1020-1023(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DLG1
9.

"Cloning and characterization of NE-dlg: a novel human homolog of the Drosophila discs large (dlg) tumor suppressor protein interacts with the APC protein."
Makino K. , Kuwahara H. , Masuko N. , Nishiyama Y. , Morisaki T. , Sasaki J. , Nakao M. , Kuwano A. , Nakata M. , Ushio Y. , Saya H.
Oncogene14:2425-2433(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DLG3
tissue: Fetal brain.
10.

"A germline mutation at the extreme 3' end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of beta-catenin in the desmoid tumor."
Couture J. , Mitri A. , Lagace R. , Smits R. , Berk T. , Bouchard H.-L. , Fodde R. , Alman B. , Bapat B.
Clin. Genet.57:205-212(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN HEREDITARY DESMOID DISEASE
11.

"Human APC2 localization and allelic imbalance."
Jarrett C.R. , Blancato J. , Cao T. , Bressette D.S. , Cepeda M. , Young P.E. , King C.R. , Byers S.W.
Cancer Res.61:7978-7984(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APC2
12.

"Characterization of functional domains of human EB1 family proteins."
Bu W. , Su L.-K.
J. Biol. Chem.278:49721-49731(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAPRE1; MAPRE2 AND MAPRE3
13.

"Adenomatous polyposis coli is down-regulated by the ubiquitin-proteasome pathway in a process facilitated by Axin."
Choi J. , Park S.Y. , Costantini F. , Jho E.-H. , Joo C.-K.
J. Biol. Chem.279:49188-49198(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION
14.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
15.

"Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli."
Takizawa S. , Nagasaka K. , Nakagawa S. , Yano T. , Nakagawa K. , Yasugi T. , Takeuchi T. , Kanda T. , Huibregtse J.M. , Akiyama T. , Taketani Y.
Genes Cells11:453-464(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH SCRIB;MUTAGENESIS OF THR-2841 AND VAL-2843
16.

"Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42."
Kawasaki Y. , Sagara M. , Shibata Y. , Shirouzu M. , Yokoyama S. , Akiyama T.
Oncogene26:7620-7627(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SPATA13
17.

"Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains."
Tran H. , Hamada F. , Schwarz-Romond T. , Bienz M.
Genes Dev.22:528-542(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEUBIQUITINATION
18.

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2671;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
19.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-780; SER-1042; SER-1360; SER-1861; SER-1863; SER-1864; THR-2151; SER-2260; SER-2270; SER-2283; SER-2473; SER-2535; SER-2671; SER-2674; THR-2679 AND SER-2789;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
20.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.

"An EB1-binding motif acts as a microtubule tip localization signal."
Honnappa S. , Gouveia S.M. , Weisbrich A. , Damberger F.F. , Bhavesh N.S. , Jawhari H. , Grigoriev I. , van Rijssel F.J. , Buey R.M. , Lawera A. , Jelesarov I. , Winkler F.K. , Wuthrich K. , Akhmanova A. , Steinmetz M.O.
Cell138:366-376(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAPRE1;SUBCELLULAR LOCATION
22.

"The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice."
Kawasaki Y. , Tsuji S. , Muroya K. , Furukawa S. , Shibata Y. , Okuno M. , Ohwada S. , Akiyama T.
EMBO Rep.10:1355-1362(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
23.

"Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration."
Sagara M. , Kawasaki Y. , Iemura S.I. , Natsume T. , Takai Y. , Akiyama T.
Oncogene28:1357-1365(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
24.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
25.

"ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells."
Zaoui K. , Benseddik K. , Daou P. , Salaun D. , Badache A.
Proc. Natl. Acad. Sci. U.S.A.107:18517-18522(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
26.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-744 AND SER-780;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
27.

"Structural and functional characterization of the Wnt inhibitor APC membrane recruitment 1 (Amer1)."
Tanneberger K. , Pfister A.S. , Kriz V. , Bryja V. , Schambony A. , Behrens J.
J. Biol. Chem.286:19204-19214(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AMER1
28.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1861; SER-1863 AND SER-1864;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
29.

"Amer2 protein is a novel negative regulator of Wnt/beta-Catenin signaling involved in neuroectodermal patterning."
Pfister A.S. , Tanneberger K. , Schambony A. , Behrens J.
J. Biol. Chem.287:1734-1741(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AMER2
30.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
31.

"Crystal structure of the amino-terminal coiled-coil domain of the APC tumor suppressor."
Day C.L. , Alber T.
J. Mol. Biol.301:147-156(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 2-55
32.

"Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex."
Eklof Spink K. , Fridman S.G. , Weis W.I.
EMBO J.20:6203-6212(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 1021-1035 IN COMPLEX WITH CTNNB1
33.

"Structural basis of the axin-adenomatous polyposis coli interaction."
Spink K.E. , Polakis P. , Weis W.I.
EMBO J.19:2270-2279(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 2034-2049 IN COMPLEX WITH AXIN
34.

"Mutations of the APC (adenomatous polyposis coli) gene."
Nagase H. , Nakamura Y.
Hum. Mutat.2:425-434(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON VARIANTS
35.

"Structural basis of the recognition of the SAMP motif of adenomatous polyposis coli by the Src-homology 3 domain."
Kaieda S. , Matsui C. , Mimori-Kiyosue Y. , Ikegami T.
Biochemistry49:5143-5153(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1578-1596 IN COMPLEX WITH ASAP1
36.

"Crystal structure of the armadillo repeat domain of adenomatous polyposis coli which reveals its inherent flexibility."
Zhang Z. , Lin K. , Gao L. , Chen L. , Shi X. , Wu G.
Biochem. Biophys. Res. Commun.412:732-736(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 407-775;DOMAIN ARM REPEATS
37.

"Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients."
Nishisho I. , Nakamura Y. , Miyoshi Y. , Miki Y. , Ando H. , Horii A. , Koyama K. , Utsunomiya J. , Baba S. , Hedge P. , Markham A. , Krush A.J. , Petersen G.M. , Hamilton S.R. , Nilbert M.C. , Levy D.B. , Bryan T.M. , Preisinger A.C. , more...
Science253:665-669(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FAP
38.

"Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene."
Miyoshi Y. , Nagase H. , Ando H. , Ichii S. , Nakatsuru S. , Aoki T. , Miki Y. , Mori T. , Nakamura Y.
Hum. Mol. Genet.1:229-233(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FAP
39.

"Somatic mutation of the APC gene in gastric cancer: frequent mutations in very well differentiated adenocarcinoma and signet-ring cell carcinoma."
Nakatsuru S. , Yanagisawa A. , Ichii S. , Tahara E. , Kato Y. , Nakamura Y. , Horii A.
Hum. Mol. Genet.1:559-563(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FAP
40.

"Screening for germ-line mutations in familial adenomatous polyposis patients: 61 new patients and a summary of 150 unrelated patients."
Nagase H. , Miyoshi Y. , Horii A. , Aoki T. , Petersen G.M. , Vogelstein B. , Maher E. , Ogawa M. , Maruyama M. , Utsunomiya J. , Baba S. , Nakamura Y.
Hum. Mutat.1:467-473(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FAP TRP-1348;VARIANTS ASP-1118; MET-1292; VAL-1304 AND SER-2502
41.

"Mutational analysis of the first 14 exons of the adenomatous polyposis coli (APC) gene."
Dobbie Z. , Spycher M. , Huerliman R. , Ammann R. , Ammann T. , Roth J. , Mueller A. , Mueller H. , Scott R.J.
Eur. J. Cancer30A:1709-1713(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FAP TRP-99
tissue: Peripheral blood lymphocyte.
42.

"Four novel mutations of the APC (adenomatous polyposis coli) gene in FAP patients."
Stella A. , Montera M. , Resta N. , Marchese C. , Susca F. , Gentile M. , Romio L. , Pilia S. , Prete F. , Mareni C. , Guanti G.
Hum. Mol. Genet.3:1687-1688(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FAP GLY-722
43.

Stella A. , Montera M. , Resta N. , Marchese C. , Susca F. , Gentile M. , Romio L. , Pilia S. , Prete F. , Mareni C. , Guanti G.
Hum. Mol. Genet.3:1918-1918(1994)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
44.

"The molecular basis of Turcot's syndrome."
Hamilton S.R. , Liu B. , Parsons R.E. , Papadopoulos N. , Jen J. , Powell S.M. , Krush A.J. , Berk T. , Cohen Z. , Tetu B. , Burger P.C. , Wood P.A. , Taqi F. , Booker S.V. , Petersen G.M. , Offerhaus G.J.A. , Tersmette A.C. , Giardiello F.M. , more...
N. Engl. J. Med.332:839-847(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN MMRCS
45.

"Somatic mutations of the APC gene in sporadic hepatoblastomas."
Oda H. , Imai Y. , Nakatsuru Y. , Hata J. , Ishikawa T.
Cancer Res.56:3320-3323(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HEPATOBLASTOMA CYS-1395
46.

"Molecular analysis of the APC gene in 105 Dutch kindreds with familial adenomatous polyposis: 67 germline mutations identified by DGGE, PTT, and southern analysis."
van der Luijt R.B. , Meera Khan P. , Vasen H.F.A. , Tops C.M.J. , van Leeuwen-Cornelisse I.S.J. , Wijnen J.T. , van der Klift H.M. , Plug R.J. , Griffioen G. , Fodde R.
Hum. Mutat.9:7-16(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FAP ILE-171
47.

"Drastic genetic instability of tumors and normal tissues in Turcot syndrome."
Miyaki M. , Nishio J. , Konishi M. , Kikuchi-Yanoshita R. , Tanaka K. , Muraoka M. , Nagato M. , Chong J.-M. , Koike M. , Terada T. , Kawahara Y. , Fukutome A. , Tomiyama J. , Chuganji Y. , Momoi M. , Utsunomiya J.
Oncogene15:2877-2881(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS COLORECTAL CARCINOMA THR-880; ILE-890 AND VAL-1508
48.

"The APC I1307K allele and breast cancer risk."
Redston M. , Nathanson K.L. , Yuan Z.Q. , Neuhausen S.L. , Satagopan J. , Wong N. , Yang D. , Nafa D. , Abrahamson J. , Ozcelik H. , Antin-Ozerkis D. , Andrulis I. , Daly M. , Pinsky L. , Schrag D. , Gallinger S. , Kaback M. , King M.-C. , more...
Nat. Genet.20:13-14(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LYS-1307
49.

"The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history."
Frayling I.M. , Beck N.E. , Ilyas M. , Dove-Edwin I. , Goodman P. , Pack K. , Bell J.A. , Williams C.B. , Hodgson S.V. , Thomas H.J.W. , Talbot I.C. , Bodmer W.F. , Tomlinson I.P.M.
Proc. Natl. Acad. Sci. U.S.A.95:10722-10727(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LYS-1307 AND GLN-1317
tissue: Peripheral blood.
50.

"The APC I1307K allele and cancer risk in a community-based study of Ashkenazi Jews."
Woodage T. , King S.M. , Wacholder S. , Hartge P. , Struewing J.P. , McAdams M. , Laken S.J. , Tucker M.A. , Brody L.C.
Nat. Genet.20:62-65(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LYS-1307
51.

"Inherited colorectal polyposis and cancer risk of the APC I1307K polymorphism."
Gryfe R. , Di Nicola N. , Lal G. , Gallinger S. , Redston M.
Am. J. Hum. Genet.64:378-384(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LYS-1307
52.

"Molecular analysis of the APC gene in 205 families: extended genotype-phenotype correlations in FAP and evidence for the role of APC amino acid changes in colorectal cancer predisposition."
Wallis Y.L. , Morton D.G. , McKeown C.M. , Macdonald F.
J. Med. Genet.36:14-20(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLY-1057; CYS-1171; ASP-1822 AND THR-2738
53.

"The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis."
Lamlum H. , Ilyas M. , Rowan A. , Clark S. , Johnson V. , Bell J.A. , Frayling I.M. , Efstathiou J. , Pack K. , Payne S. , Roylance R. , Gorman P. , Sheer D. , Neale K. , Phillips R. , Talbot I.C. , Bodmer W.F. , Tomlinson I.P.M.
Nat. Med.5:1071-1075(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FAP PRO-1184
54.

"APC mutations in sporadic medulloblastomas."
Huang H. , Mahler-Araujo B.M. , Sankila A. , Chimelli L. , Yonekawa Y. , Kleihues P. , Ohgaki H.
Am. J. Pathol.156:433-437(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MDB VAL-1296; ILE-1472 AND GLY-1495
55.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-1254

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