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Index > Protein center > APLN(Gene name) > Human
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  • APLN (Gene name),
  • Apelin (Protein name ),  APEL_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    APLN(APEL);
    Protein name:
    Apelin;
    Alternative:
    APJ endogenous ligand;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    77
    Sequence:
    50:
    MNLRLCVQAL | LLLWLSLTAV | CGGSLMPLPD | GNGLEDGNVR | HLVQPRGSRN | 
    77:
    GPGPWQGGRR | KFRRQRPRLS | HKGPMPF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    KEGG:
    Pfam:
    UniGene:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Apelin
    Cat.:
    E2232h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Apelin
    Cat.:
    E2232r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Apelin
    Cat.:
    E2232m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Apelin
    Cat.:
    E2232b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Apelin
    Cat.:
    U2232r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Apelin
    Cat.:
    U2232b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Apelin
    Cat.:
    U2232m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Apelin
    Cat.:
    U2232h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Apelin
    Polyclonal Antibody for Human Apelin
    Cat.:
    P2232Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Apelin
    Cat.:
    P2232Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Apelin
    Cat.:
    P2232Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Apelin
    Monoclonal Antibody for Human Apelin
    Monoclonal Antibody for Human Apelin
    Monoclonal Antibody for Human Apelin
    Protein for Human Apelin
    Protein for Human Apelin
    Protein for Human Apelin
    Protein for Human Apelin

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    References
    1. 1.
      "Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor."
      Tatemoto K. , Hosoya M. , Habata Y. , Fujii R. , Kakegawa T. , Zou M.-X. , Kawamata Y. , Fukusumi S. , Hinuma S. , Kitada C. , Kurokawa T. , Onda H. , Fujino M.
      Biochem. Biophys. Res. Commun.251:471-476(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Brain.
    2. 2.
      "Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum."
      Habata Y. , Fujii R. , Hosoya M. , Fukusumi S. , Kawamata Y. , Hinuma S. , Kitada C. , Nishizawa N. , Murosaki S. , Kurokawa T. , Onda H. , Tatemoto K. , Fujino M.
      Biochim. Biophys. Acta1452:25-35(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Brain.
    3. 3.
      "Characterization of apelin, the ligand for the APJ receptor."
      Lee D.K. , Cheng R. , Nguyen T. , Fan T. , Kariyawasam A.P. , Liu Y. , Osmond D.H. , George S.R. , O'Dowd B.F.
      J. Neurochem.74:34-41(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Hypothalamus.
    4. 4.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Kidney.
    6. 6.
      "Apelin, the natural ligand of the orphan seven-transmembrane receptor APJ, inhibits human immunodeficiency virus type 1 entry."
      Cayabyab M. , Hinuma S. , Farzan M. , Choe H. , Fukusumi S. , Kitada C. , Nishizawa N. , Hosoya M. , Nishimura O. , Messele T. , Pollakis G. , Goudsmit J. , Fujino M. , Sodroski J.
      J. Virol.74:11972-11976(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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