Gene name:
APOA5 (UNQ411/PRO773;RAP3) ;
Protein name:
Apolipoprotein A-V (Apo-AV;ApoA-V) ;
Alternative:
Regeneration-associated protein 3 ;Apolipoprotein A5 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with GPIHBP1.
Function:
Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages.
Subcellular Location:
Secreted
Protein Attributes:
50:
MASMAAVLTW | ALALLSAFSA | TQARKGFWDY | FSQTSGDKGR | VEQIHQQKMA |
100:
REPATLKDSL | EQDLNNMNKF | LEKLRPLSGS | EAPRLPQDPV | GMRRQLQEEL |
150:
EEVKARLQPY | MAEAHELVGW | NLEGLRQQLK | PYTMDLMEQV | ALRVQELQEQ |
200:
LRVVGEDTKA | QLLGGVDEAW | ALLQGLQSRV | VHHTGRFKEL | FHPYAESLVS |
250:
GIGRHVQELH | RSVAPHAPAS | PARLSRCVQV | LSRKLTLKAK | ALHARIQQNL |
300:
DQLREELSRA | FAGTGTEEGA | GPDPQMLSEE | VRQRLQAFRQ | DTYLQIAAFT |
350:
RAIDQETEEV | QQQLAPPPPG | HSAFAPEFQQ | TDSGKVLSKL | QARLDDLWED |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Human Apo-AV
ELISA Kit for Human Apo-AV
ELISA Kit for Human Apo-AV
CLIA Kit for Human Apo-AV
CLIA Kit for Human Apo-AV
CLIA Kit for Human Apo-AV
Polyclonal Antibody for Human Apo-AV
Polyclonal Antibody for Human Apo-AV
Polyclonal Antibody for Human Apo-AV
Monoclonal Antibody for Human Apo-AV
Monoclonal Antibody for Human Apo-AV
Monoclonal Antibody for Human Apo-AV
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
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Liver .
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Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS TRP-19 AND MET-153
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Liver .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
10.
"The novel apolipoprotein A5 is present in human serum, is associated with VLDL, HDL, and chylomicrons, and circulates at very low concentrations compared with other apolipoproteins."
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Cited for : FUNCTION;TISSUE SPECIFICITY
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH GPIHBP1
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT TRP-19
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT CYS-185
15.
"Apoa5 Q139X truncation predisposes to late-onset hyperchylomicronemia due to lipoprotein lipase impairment."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN HLPP5