PMAIP1 ELISA Kit for Human(Homo sapiens) | EIAab.comPMAIP1 ELISA Kit for Human(Homo sapiens) | EIAab.com

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PMAIP1 (Gene name),

Phorbol-12-myristate-13-acetate-induced protein 1 (Protein name ), APR_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Gene name:

PMAIP1(NOXA);

Protein name:

Phorbol-12-myristate-13-acetate-induced protein 1(PMA-induced protein 1);

Alternative:

Protein Noxa;Immediate-early-response protein APR;

Organism:

PMAIP1 (Homo sapiens).

General Annotation

Sub Unit:

Interacts with MCL1 and BAX.

Function:

Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.

Subcellular Location:

Mitochondrion

Protein Attributes:

Sequence length:

136

Sequence:

50:

MPGKKARKNA | QPSPARAPAG | PAGTAGTARD | QAGFAIGMQL | RFTRGKKLLS |

100:

SSLSSSPLAL | PRGHEEQVQV | AGSRVCYSTQ | EIWRQTELPA | ETSESDIQTL |

136:

LLRNLTASKT | CMRGLLQKSF | LRRCTFHQFE | ERLHCN

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Pfam:

MIM:

STRING:

9606.ENSP00000326119

KEGG:

String:

UniGene:

Hs.96

Uniprot:

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ELISA Kit for Human PMA-induced protein 1

Cat.:

E13268r

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Packing:

96T

ELISA Kit for Human PMA-induced protein 1

Cat.:

E13268m

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MSDS:

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Packing:

96T

ELISA Kit for Human PMA-induced protein 1

Cat.:

E13268h

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Manual:

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ELISA Kit for Human PMA-induced protein 1

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CLIA Kit for Human PMA-induced protein 1

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CLIA Kit for Human PMA-induced protein 1

Cat.:

U13268m

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MSDS:

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Packing:

96T

CLIA Kit for Human PMA-induced protein 1

Cat.:

U13268h

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Packing:

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CLIA Kit for Human PMA-induced protein 1

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Polyclonal Antibody for Human PMA-induced protein 1

Polyclonal Antibody for Human PMA-induced protein 1

Polyclonal Antibody for Human PMA-induced protein 1

Polyclonal Antibody for Human PMA-induced protein 1

Monoclonal Antibody for Human PMA-induced protein 1

Monoclonal Antibody for Human PMA-induced protein 1

Monoclonal Antibody for Human PMA-induced protein 1

Monoclonal Antibody for Human PMA-induced protein 1

Protein for Human PMA-induced protein 1

Protein for Human PMA-induced protein 1

Protein for Human PMA-induced protein 1

Protein for Human PMA-induced protein 1

R&D Technical Data

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12% SDS-PAGE Analysis

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Precision

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Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤ 6.1%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤ 11.3%

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Recovery

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Recovery was determined by spiking various levels of ACE into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	99	92-104
Plasma	98	94-107

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Linearity

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The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	92-105%	91-101%	96-105%	93-106%
EDTA plasma(n=5)	89-97%	92-104%	89-99%	92-107%
heparin plasma(n=5)	92-104%	94-110%	101-108%	93-109%

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References

1.

"Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line."
Hijikata M. , Kato N. , Sato T. , Kagami Y. , Shimotohno K.
J. Virol.64:4632-4639(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
3.

"DNA sequence and analysis of human chromosome 18."
Nusbaum C. , Zody M.C. , Borowsky M.L. , Kamal M. , Kodira C.D. , Taylor T.D. , Whittaker C.A. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Yang X. , Abouelleil A. , Allen N.R. , Anderson S. , Bloom T. , Bugalter B. , Butler J. , more...
Nature437:551-555(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Ovary.
tissue: Uterus.
5.

"Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis."
Oda E. , Ohki R. , Murasawa H. , Nemoto J. , Shibue T. , Yamashita T. , Tokino T. , Taniguchi T. , Tanaka N.
Science288:1053-1058(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
6.

"Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection."
Sun Y. , Leaman D.W.
J. Biol. Chem.280:15561-15568(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION;SUBCELLULAR LOCATION;INTERACTION WITH BAX;MUTAGENESIS OF LEU-29
7.

"Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function."
Chen L. , Willis S.N. , Wei A. , Smith B.J. , Fletcher J.I. , Hinds M.G. , Colman P.M. , Day C.L. , Adams J.M. , Huang D.C.S.
Mol. Cell17:393-403(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY;MUTAGENESIS OF PHE-32 AND LYS-35;INTERACTION WITH MCL1
8.

"Functional linkage between NOXA and Bim in mitochondrial apoptotic events."
Han J. , Goldstein L.A. , Hou W. , Rabinowich H.
J. Biol. Chem.282:16223-16231(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MCL1;INDUCTION;SUBCELLULAR LOCATION
9.

"Structural insights into the degradation of Mcl-1 induced by BH3 domains."
Czabotar P.E. , Lee E.F. , van Delft M.F. , Day C.L. , Smith B.J. , Huang D.C.S. , Fairlie W.D. , Hinds M.G. , Colman P.M.
Proc. Natl. Acad. Sci. U.S.A.104:6217-6222(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF LEU-29; PHE-32 AND LEU-36;INTERACTION WITH MCL1
10.

"Crystal structure of human BFL-1 in complex with NOXA BH3 peptide."
Northeast structural genomics consortium (NESG)
Submitted (2010-07) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.24 ANGSTROMS) OF 19-43 IN COMPLEX WITH BCL2A1

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