AQP2 ELISA Kit for Human(Homo sapiens) | EIAab.comAQP2 ELISA Kit for Human(Homo sapiens)

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AQP2 (Gene name),

Aquaporin-2 (Protein name ), AQP2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

AQP2;

Protein name:

Aquaporin-2(AQP-2);

Alternative:

Aquaporin-CD(AQP-CD);ADH water channel;WCH-CD;Collecting duct water channel protein;Water channel protein for renal collecting duct;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.

Subcellular Location:

Apical cell membrane Multi-pass membrane protein Cytoplasmic vesicle membrane Multi-pass membrane protein Shuttles from vesicles to the apical membrane.

Protein Attributes:

Sequence length:

271

Sequence:

50:

100:

150:

200:

250:

271:

VRRRQSVELH | SPQSLPRGTK | A

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

107777

UniGene:

Hs.130730

String:

P41181

KEGG:

hsa:359

STRING:

9606.ENSP00000199280

SMR:

P41181

Pfam:

PF00230

Uniprot:

P41181

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ELISA Kit for Human AQP-2

Cat.:

E0580b

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96T

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ELISA Kit for Human AQP-2

Cat.:

E0580r

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96T

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ELISA Kit for Human AQP-2

Cat.:

E0580m

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96T

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ELISA Kit for Human AQP-2

Cat.:

E0580h

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96T

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ELISA Kit for Human AQP-2

Cat.:

E0580d

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96T

ELISA Kit for Human AQP-2

MSDS:

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CLIA Kit for Human AQP-2

Cat.:

U0580h

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Packing:

96T

CLIA Kit for Human AQP-2

MSDS:

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CLIA Kit for Human AQP-2

Cat.:

U0580b

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Packing:

96T

CLIA Kit for Human AQP-2

Cat.:

U0580d

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96T

CLIA Kit for Human AQP-2

Cat.:

U0580m

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MSDS:

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Packing:

96T

CLIA Kit for Human AQP-2

Cat.:

U0580r

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Packing:

96T

Polyclonal Antibody for Human AQP-2

Cat.:

P0580Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human AQP-2

Cat.:

P0580Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human AQP-2

Cat.:

P0580Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human AQP-2

Monoclonal Antibody for Human AQP-2

Protein for Human AQP-2

Cat.:

R0580h

Price:

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Packing:

1mg

Purity:

>90%

Protein for Human AQP-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine."
Deen P.M.T. , Verdijk M.A.J. , Knoers V.V.A.M. , Wieringa B. , Monnens L.A.H. , van Os C.H. , van Oost B.A.
Science264:92-94(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.

"Isolation of human aquaporin-CD gene."
Uchida S. , Sasaki S. , Fushimi K. , Marumo F.
J. Biol. Chem.269:23451-23455(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Patients with autosomal nephrogenic diabetes insipidus homozygous for mutations in the aquaporin 2 water-channel gene."
van Lieburg A.F. , Verdijk M.A.J. , Knoers V.V.A.M. , van Essen A.J. , Proesmans W. , Mallmann R. , Monnens L.A.H. , van Oost B.A. , van Os C.H. , Deen P.M.T.
Am. J. Hum. Genet.55:648-652(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS ANDI ARG-64; CYS-187 AND PRO-216
4.

"Cloning, characterization, and chromosomal mapping of human aquaporin of collecting duct."
Sasaki S. , Fushimi K. , Saito H. , Saito F. , Uchida S. , Ishibashi K. , Kuwahara M. , Ikeuchi T. , Inui K. , Nakajima K.
J. Clin. Invest.93:1250-1256(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Kidney.
5.

"Heteroligomerization of an aquaporin-2 mutant with wild-type aquaporin-2 and their misrouting to late endosomes/lysosomes explains dominant nephrogenic diabetes insipidus."
Marr N. , Bichet D.G. , Lonergan M. , Arthus M.-F. , Jeck N. , Seyberth H.W. , Rosenthal W. , van Os C.H. , Oksche A. , Deen P.M.T.
Hum. Mol. Genet.11:779-789(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Kidney.
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Colon.
7.

"The role of putative phosphorylation sites in the targeting and shuttling of the aquaporin-2 water channel."
van Balkom B.W.M. , Savelkoul P.J.M. , Markovich D. , Hofman E. , Nielsen S. , van der Sluijs P. , Deen P.M.T.
J. Biol. Chem.277:41473-41479(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-256;MUTAGENESIS OF SER-148; SER-229; SER-231; THR-244 AND SER-256
8.

"Two novel mutations in the aquaporin-2 and the vasopressin V2 receptor genes in patients with congenital nephrogenic diabetes insipidus."
Oksche A. , Moeller A. , Dickson J. , Rosendahl W. , Rascher W. , Bichet D.G. , Rosenthal W.
Hum. Genet.98:587-589(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ANDI CYS-202
9.

"Identification and characterization of aquaporin-2 water channel mutations causing nephrogenic diabetes insipidus with partial vasopressin response."
Canfield M.C. , Tamarappoo B.K. , Moses A.M. , Verkman A.S. , Holtzman E.J.
Hum. Mol. Genet.6:1865-1871(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ANDI VAL-22 AND TRP-181
10.

"New mutations in the AQP2 gene in nephrogenic diabetes insipidus resulting in functional but misrouted water channels."
Mulders S.M. , Knoers N.V. , Van Lieburg A.F. , Monnens L.A. , Leumann E. , Wuhl E. , Schober E. , Rijss J.P.L. , Van Os C.H. , Deen P.M.T.
J. Am. Soc. Nephrol.8:242-248(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ANDI SER-68; MET-126 AND THR-147
11.

"Mutations in the vasopressin V2 receptor and aquaporin-2 genes in 12 families with congenital nephrogenic diabetes insipidus."
Vargas-Poussou R. , Forestier L. , Dautzenberg M.D. , Niaudet P. , Dechaux M. , Antignac C.
J. Am. Soc. Nephrol.8:1855-1862(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ANDI MET-168 AND PRO-216
12.

"Aquaporin-2, a vasopressin-sensitive water channel, and nephrogenic diabetes insipidus."
Kuwahara M.
Intern. Med.37:215-217(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ANDI MET-125; ARG-175; THR-190 AND LEU-262
13.

"An aquaporin-2 water channel mutant which causes autosomal dominant nephrogenic diabetes insipidus is retained in the Golgi complex."
Mulders S.M. , Bichet D.G. , Rijss J.P.L. , Kamsteeg E.-J. , Arthus M.-F. , Lonergan M. , Fujiwara M. , Morgan K. , Leijendekker R. , van der Sluijs P. , van Os C.H. , Deen P.M.T.
J. Clin. Invest.102:57-66(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ANDI LYS-258
14.

"Novel mutations in aquaporin-2 gene in female siblings with nephrogenic diabetes insipidus: evidence of disrupted water channel function."
Goji K. , Kuwahara M. , Gu Y. , Matsuo M. , Marumo F. , Sasaki S.
J. Clin. Endocrinol. Metab.83:3205-3209(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ANDI MET-125 AND ARG-175
15.

"Cell-biologic and functional analyses of five new Aquaporin-2 missense mutations that cause recessive nephrogenic diabetes insipidus."
Marr N. , Bichet D.G. , Hoefs S. , Savelkoul P.J.M. , Konings I.B. , De Mattia F. , Graat M.P. , Arthus M.-F. , Lonergan M. , Fujiwara T.M. , Knoers N.V. , Landau D. , Balfe W.J. , Oksche A. , Rosenthal W. , Muller D. , Van Os C.H. , Deen P.M.
J. Am. Soc. Nephrol.13:2267-2277(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ANDI PRO-28; VAL-47; MET-71; MET-125; ARG-175 AND ALA-185;VARIANT ILE-194
16.

"Two novel aquaporin-2 mutations responsible for congenital nephrogenic diabetes insipidus in Chinese families."
Lin S.H. , Bichet D.G. , Sasaki S. , Kuwahara M. , Arthus M.-F. , Lonergan M. , Lin Y.-F.
J. Clin. Endocrinol. Metab.87:2694-2700(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ANDI PRO-57 AND VAL-100
17.

"A novel mechanism in recessive nephrogenic diabetes insipidus: wild-type aquaporin-2 rescues the apical membrane expression of intracellularly retained AQP2-P262L."
de Mattia F. , Savelkoul P.J.M. , Bichet D.G. , Kamsteeg E.-J. , Konings I.B.M. , Marr N. , Arthus M.-F. , Lonergan M. , van Os C.H. , van der Sluijs P. , Robertson G. , Deen P.M.T.
Hum. Mol. Genet.13:3045-3056(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ANDI CYS-187; THR-190 AND LEU-262;CHARACTERIZATION OF VARIANTS ANDI CYS-187; THR-190 AND LEU-262
18.

"Lack of arginine vasopressin-induced phosphorylation of aquaporin-2 mutant AQP2-R254L explains dominant nephrogenic diabetes insipidus."
de Mattia F. , Savelkoul P.J.M. , Kamsteeg E.-J. , Konings I.B.M. , van der Sluijs P. , Mallmann R. , Oksche A. , Deen P.M.T.
J. Am. Soc. Nephrol.16:2872-2880(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ANDI LEU-254;CHARACTERIZATION OF VARIANT ANDI LEU-254
19.

"Two novel mutations in the aquaporin 2 gene in a girl with congenital nephrogenic diabetes insipidus."
Cheong H.I. , Cho S.J. , Zheng S.H. , Cho H.Y. , Ha I.S. , Choi Y.
J. Korean Med. Sci.20:1076-1078(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ANDI ASP-70 AND HIS-187
20.

"Novel mutations underlying nephrogenic diabetes insipidus in Arab families."
Carroll P. , Al-Mojalli H. , Al-Abbad A. , Al-Hassoun I. , Al-Hamed M. , Al-Amr R. , Butt A.I. , Meyer B.F.
Genet. Med.8:443-447(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ANDI ARG-100 AND SER-180
21.

"p.R254Q mutation in the aquaporin-2 water channel causing dominant nephrogenic diabetes insipidus is due to a lack of arginine vasopressin-induced phosphorylation."
Savelkoul P.J.M. , De Mattia F. , Li Y. , Kamsteeg E.-J. , Konings I.B.M. , van der Sluijs P. , Deen P.M.T.
Hum. Mutat.30:E891-E903(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN ANDI;VARIANT ANDI GLN-254;CHARACTERIZATION OF VARIANT ANDI GLN-254
22.

"Repulsion between Lys258 and upstream arginines explains the missorting of the AQP2 mutant p.Glu258Lys in nephrogenic diabetes insipidus."
Kamsteeg E.-J. , Stoffels M. , Tamma G. , Konings I.B.M. , Deen P.M.T.
Hum. Mutat.30:1387-1396(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MISSORTING MOTIF OF VARIANT ANDI LYS-258
23.

"Congenital nephrogenic diabetes insipidus with a novel mutation in the aquaporin 2 gene."
Park Y.J. , Baik H.W. , Cheong H.I. , Kang J.H.
Biomed. Rep.2:596-598(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ANDI MET-108

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