Protein name:
Aquaporin-4 (AQP-4) ;
Alternative:
WCH4 ;Mercurial-insensitive water channel (MIWC) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Function:
Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system. It is expressed predominantly in the ependymal cell lining the aqueductal system and over the space of the brain in contact with the subarachnoid space, as cerebrospinal fluid fills these structures it may facilitate water balance between brain parenchyma and the fluid compartment. In the plasma membranes of the neurons of the paraventricular and supraoptic nuclei, it may mediate rapid changes in cell volume in response to local shifts in extracellular osmolarity.
Subcellular Location:
Membrane
Multi-pass membrane protein
Protein Attributes:
50:
MSDGAAARRW | GKCGPPCSRE | SIMVAFKGVW | TQAFWKAVTA | EFLAMLIFVL |
100:
LSVGSTINWG | GSENPLPVDM | VLISLCFGLS | IATMVQCFGH | ISGGHINPAV |
150:
TVAMVCTRKI | SIAKSVFYIT | AQCLGAIIGA | GILYLVTPPS | VVGGLGVTTV |
200:
HGNLTAGHGL | LVELIITFQL | VFTIFASCDS | KRTDVTGSVA | LAIGFSVAIG |
250:
HLFAINYTGA | SMNPARSFGP | AVIMGNWENH | WIYWVGPIIG | AVLAGALYEY |
300:
VFCPDVELKR | RLKEAFSKAA | QQTKGSYMEV | EDNRSQVETE | DLILKPGVVH |
323:
VIDIDRGDEK | KGKDSSGEVL | SSV
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
Rat
Polyclonal Antibody for Rat AQP-4
Polyclonal Antibody for Rat AQP-4
Polyclonal Antibody for Rat AQP-4
Polyclonal Antibody for Rat AQP-4
Monoclonal Antibody for Rat AQP-4
Monoclonal Antibody for Rat AQP-4
Monoclonal Antibody for Rat AQP-4
Monoclonal Antibody for Rat AQP-4
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];MUTAGENESIS OF HIS-201
tissue :
Brain .
2.
"Isolation of an aquaporin-4 water channel (AQP4) gene induced following cerebral ischemia from the rat brain using modified subtractive hybridization and differential screening."
Chen D.
,
Chen J.
,
Jing K.
,
Simon R.P.
,
Graham S.H.
Submitted (1999-04) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Brain .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 23-323
tissue :
Lung .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-285
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-111
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-180
8.
"Implications of the aquaporin-4 structure on array formation and cell adhesion."
Hiroaki Y.
,
Tani K.
,
Kamegawa A.
,
Gyobu N.
,
Nishikawa K.
,
Suzuki H.
,
Walz T.
,
Sasaki S.
,
Mitsuoka K.
,
Kimura K.
,
Mizoguchi A.
,
Fujiyoshi Y.
J. Mol. Biol.355:628-639(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 23-323;SUBUNIT
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 23-323;SUBUNIT