Gene name:
ARC (KIAA0278) ;
Protein name:
Activity-regulated cytoskeleton-associated protein ;
Alternative:
Activity-regulated gene 3.1 protein homolog (Arg3.1) ;ARC/ARG3.1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2.
Function:
Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors.
Subcellular Location:
Cytoplasm
cytoskeleton
Endosome
Cytoplasmic vesicle
secretory vesicle
acrosome
Cell junction
synapse
postsynaptic cell membrane
postsynaptic density
Cell projection
dendrite
Cell projection
dendritic spine
Cell junction
synapse
Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail.
Protein Attributes:
50:
MELDHRTSGG | LHAYPGPRGG | QVAKPNVILQ | IGKCRAEMLE | HVRRTHRHLL |
100:
AEVSKQVERE | LKGLHRSVGK | LESNLDGYVP | TSDSQRWKKS | IKACLCRCQE |
150:
TIANLERWVK | REMHVWREVF | YRLERWADRL | ESTGGKYPVG | SESARHTVSV |
200:
GVGGPESYCH | EADGYDYTVS | PYAITPPPAA | GELPGQEPAE | AQQYQPWVPG |
250:
EDGQPSPGVD | TQIFEDPREF | LSHLEEYLRQ | VGGSEEYWLS | QIQNHMNGPA |
300:
KKWWEFKQGS | VKNWVEFKKE | FLQYSEGTLS | REAIQRELDL | PQKQGEPLDQ |
350:
FLWRKRDLYQ | TLYVDADEEE | IIQYVVGTLQ | PKLKRFLRHP | LPKTLEQLIQ |
396:
RGMEVQDDLE | QAAEPAGPHL | PVEDEAETLT | PAPNSESVAS | DRTQPE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Mouse
Rat
ELISA Kit for Human Activity-regulated cytoskeleton-associated protein
ELISA Kit for Human Activity-regulated cytoskeleton-associated protein
ELISA Kit for Human Activity-regulated cytoskeleton-associated protein
ELISA Kit for Human Activity-regulated cytoskeleton-associated protein
CLIA Kit for Human Activity-regulated cytoskeleton-associated protein
CLIA Kit for Human Activity-regulated cytoskeleton-associated protein
CLIA Kit for Human Activity-regulated cytoskeleton-associated protein
CLIA Kit for Human Activity-regulated cytoskeleton-associated protein
Polyclonal Antibody for Human Activity-regulated cytoskeleton-associated protein
Polyclonal Antibody for Human Activity-regulated cytoskeleton-associated protein
Polyclonal Antibody for Human Activity-regulated cytoskeleton-associated protein
Polyclonal Antibody for Human Activity-regulated cytoskeleton-associated protein
Monoclonal Antibody for Human Activity-regulated cytoskeleton-associated protein
Monoclonal Antibody for Human Activity-regulated cytoskeleton-associated protein
Monoclonal Antibody for Human Activity-regulated cytoskeleton-associated protein
Monoclonal Antibody for Human Activity-regulated cytoskeleton-associated protein
Protein for Human Activity-regulated cytoskeleton-associated protein
Protein for Human Activity-regulated cytoskeleton-associated protein
Protein for Human Activity-regulated cytoskeleton-associated protein
Protein for Human Activity-regulated cytoskeleton-associated protein
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Mutation screening of the chromosome 8q24.3-human activity-regulated cytoskeleton-associated gene (ARC) in idiopathic generalized epilepsy."
Haug K.
,
Kremerskothen J.
,
Hallmann K.
,
Sander T.
,
Dullinger J.
,
Rau B.
,
Beyenburg S.
,
Lentze M.J.
,
Barnekow A.
,
Elger C.E.
,
Propping P.
,
Heils A.
Mol. Cell. Probes14:255-260(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
tissue :
Forebrain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
tissue :
Uterus .
4.
"Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration."
Bai S.W.
,
Herrera-Abreu M.T.
,
Rohn J.L.
,
Racine V.
,
Tajadura V.
,
Suryavanshi N.
,
Bechtel S.
,
Wiemann S.
,
Baum B.
,
Ridley A.J.
BMC Biol.9:54-54(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION