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Index > Protein center > ARC(Gene name) > Human
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  • ARC (Gene name),
  • Activity-regulated cytoskeleton-associated protein (Protein name ),  ARC_HUMAN from NCBI database.
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  • Gene name:
    ARC(KIAA0278);
    Protein name:
    Activity-regulated cytoskeleton-associated protein;
    Alternative:
    Activity-regulated gene 3.1 protein homolog(Arg3.1);ARC/ARG3.1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with SH3GL1/endophilin-2, SH3GL3/endophilin-3 and DNM2/DYN2.
    Function:
    Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors.
    Subcellular Location:
    Cytoplasm cytoskeleton Endosome Cytoplasmic vesicle secretory vesicle acrosome Cell junction synapse postsynaptic cell membrane postsynaptic density Cell projection dendrite Cell projection dendritic spine Cell junction synapse Associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail.
    Protein Attributes:
    Sequence length:
    396
    Sequence:
    50:
    MELDHRTSGG | LHAYPGPRGG | QVAKPNVILQ | IGKCRAEMLE | HVRRTHRHLL | 
    100:
    AEVSKQVERE | LKGLHRSVGK | LESNLDGYVP | TSDSQRWKKS | IKACLCRCQE | 
    150:
    TIANLERWVK | REMHVWREVF | YRLERWADRL | ESTGGKYPVG | SESARHTVSV | 
    200:
    GVGGPESYCH | EADGYDYTVS | PYAITPPPAA | GELPGQEPAE | AQQYQPWVPG | 
    250:
    EDGQPSPGVD | TQIFEDPREF | LSHLEEYLRQ | VGGSEEYWLS | QIQNHMNGPA | 
    300:
    KKWWEFKQGS | VKNWVEFKKE | FLQYSEGTLS | REAIQRELDL | PQKQGEPLDQ | 
    350:
    FLWRKRDLYQ | TLYVDADEEE | IIQYVVGTLQ | PKLKRFLRHP | LPKTLEQLIQ | 
    396:
    RGMEVQDDLE | QAAEPAGPHL | PVEDEAETLT | PAPNSESVAS | DRTQPE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    MIM:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Activity-regulated cytoskeleton-associated protein
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    E7736h
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    96T
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    ELISA Kit for Human Activity-regulated cytoskeleton-associated protein
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    ELISA Kit for Human Activity-regulated cytoskeleton-associated protein
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    E7736m
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    Packing:
    96T
    ELISA Kit for Human Activity-regulated cytoskeleton-associated protein
    Cat.:
    E7736r
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    96T
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    CLIA Kit for Human Activity-regulated cytoskeleton-associated protein
    Cat.:
    U7736r
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    Packing:
    96T
    CLIA Kit for Human Activity-regulated cytoskeleton-associated protein
    MSDS:
    Please sign in first.
    CLIA Kit for Human Activity-regulated cytoskeleton-associated protein
    Cat.:
    U7736h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Activity-regulated cytoskeleton-associated protein
    Cat.:
    U7736m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Activity-regulated cytoskeleton-associated protein
    Cat.:
    P7736Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Activity-regulated cytoskeleton-associated protein
    Polyclonal Antibody for Human Activity-regulated cytoskeleton-associated protein
    Cat.:
    P7736Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Activity-regulated cytoskeleton-associated protein
    Monoclonal Antibody for Human Activity-regulated cytoskeleton-associated protein
    Monoclonal Antibody for Human Activity-regulated cytoskeleton-associated protein
    Monoclonal Antibody for Human Activity-regulated cytoskeleton-associated protein
    Monoclonal Antibody for Human Activity-regulated cytoskeleton-associated protein
    Protein for Human Activity-regulated cytoskeleton-associated protein
    Protein for Human Activity-regulated cytoskeleton-associated protein
    Protein for Human Activity-regulated cytoskeleton-associated protein
    Protein for Human Activity-regulated cytoskeleton-associated protein

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    References
    1. 1.
      "Mutation screening of the chromosome 8q24.3-human activity-regulated cytoskeleton-associated gene (ARC) in idiopathic generalized epilepsy."
      Haug K. , Kremerskothen J. , Hallmann K. , Sander T. , Dullinger J. , Rau B. , Beyenburg S. , Lentze M.J. , Barnekow A. , Elger C.E. , Propping P. , Heils A.
      Mol. Cell. Probes14:255-260(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
      tissue: Forebrain.
    2. 2.
      "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
      Nagase T. , Seki N. , Ishikawa K. , Ohira M. , Kawarabayasi Y. , Ohara O. , Tanaka A. , Kotani H. , Miyajima N. , Nomura N.
      DNA Res.3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
      tissue: Uterus.
    4. 4.
      "Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration."
      Bai S.W. , Herrera-Abreu M.T. , Rohn J.L. , Racine V. , Tajadura V. , Suryavanshi N. , Bechtel S. , Wiemann S. , Baum B. , Ridley A.J.
      BMC Biol.9:54-54(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
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