Protein name:
Aryl hydrocarbon receptor nuclear translocator (ARNT protein) ;
Alternative:
Dioxin receptor, nuclear translocator ;Class E basic helix-loop-helix protein 2 (bHLHe2) ;Hypoxia-inducible factor 1-beta (HIF-1-beta;HIF1-beta) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with AHR, AHRR, HIF1A and EPAS1/HIF2A as well as with other bHLH proteins. Interacts with TACC3 (By similarity). Interacts with NOCA7.
Function:
Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MAATTANPEM | TSDVPSLGPA | IASGNSGPGI | QGGGAIVQRA | IKRRPGLDFD |
100:
DDGEGNSKFL | RCDDDQMSND | KERFARSDDE | QSSADKERLA | RENHSEIERR |
150:
RRNKMTAYIT | ELSDMVPTCS | ALARKPDKLT | ILRMAVSHMK | SLRGTGNTST |
200:
DGSYKPSFLT | DQELKHLILE | AADGFLFIVS | CETGRVVYVS | DSVTPVLNQP |
250:
QSEWFGSTLY | DQVHPDDVDK | LREQLSTSEN | ALTGRILDLK | TGTVKKEGQQ |
300:
SSMRMCMGSR | RSFICRMRCG | SSSVDPVSVN | RLSFVRNRCR | NGLGSVKDGE |
350:
PHFVVVHCTG | YIKAWPPAGV | SLPDDDPEAG | QGSKFCLVAI | GRLQVTSSPN |
400:
CTDMSNVCQP | TEFISRHNIE | GIFTFVDHRC | VATVGYQPQE | LLGKNIVEFC |
450:
HPEDQQLLRD | SFQQVVKLKG | QVLSVMFRFR | SKNQEWLWMR | TSSFTFQNPY |
500:
SDEIEYIICT | NTNVKNSSQE | PRPTLSNTIQ | RPQLGPTANL | PLEMGSGQLA |
550:
PRQQQQQTEL | DMVPGRDGLA | SYNHSQVVQP | VTTTGPEHSK | PLEKSDGLFA |
600:
QDRDPRFSEI | YHNINADQSK | GISSSTVPAT | QQLFSQGNTF | PPTPRPAENF |
650:
RNSGLAPPVT | IVQPSASAGQ | MLAQISRHSN | PTQGATPTWT | PTTRSGFSAQ |
700:
QVATQATAKT | RTSQFGVGSF | QTPSSFSSMS | LPGAPTASPG | AAAYPSLTNR |
750:
GSNFAPETGQ | TAGQFQTRTA | EGVGVWPQWQ | GQQPHHRSSS | SEQHVQQPPA |
789:
QQPGQPEVFQ | EMLSMLGDQS | NSYNNEEFPD | LTMFPPFSE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rabbit
Bovine
Rat
ELISA Kit for Human ARNT protein
ELISA Kit for Human ARNT protein
ELISA Kit for Human ARNT protein
ELISA Kit for Human ARNT protein
ELISA Kit for Human ARNT protein
CLIA Kit for Human ARNT protein
CLIA Kit for Human ARNT protein
CLIA Kit for Human ARNT protein
CLIA Kit for Human ARNT protein
CLIA Kit for Human ARNT protein
Polyclonal Antibody for Human ARNT protein
Polyclonal Antibody for Human ARNT protein
Polyclonal Antibody for Human ARNT protein
Polyclonal Antibody for Human ARNT protein
Polyclonal Antibody for Human ARNT protein
Monoclonal Antibody for Human ARNT protein
Monoclonal Antibody for Human ARNT protein
Monoclonal Antibody for Human ARNT protein
Monoclonal Antibody for Human ARNT protein
Monoclonal Antibody for Human ARNT protein
Protein for Human ARNT protein
Protein for Human ARNT protein
Protein for Human ARNT protein
Protein for Human ARNT protein
Protein for Human ARNT protein
R&D Technical Data
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Precision
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Recovery
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Linearity
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Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
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Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.
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Cited for : PROTEIN SEQUENCE OF 186-203 AND 662-694
10.
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Cited for : CHARACTERIZATION
11.
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Cited for : DNA-BINDING;MUTAGENESIS OF ARG-91; ASN-93; HIS-94; GLU-98; ARG-99; ARG-101 AND ARG-102
12.
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Cited for : INTERACTION WITH NOCA7
13.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
14.
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Cited for : INTERACTION WITH HIF1A
15.
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P.
,
Lasa M.
,
Polevoda B.
,
Gazquez C.
,
Elosegui-Artola A.
,
Kim D.S.
,
De Juan-Pardo E.
,
Demeyer K.
,
Hole K.
,
Larrea E.
,
Timmerman E.
,
Prieto J.
,
Arnesen T.
,
Sherman F.
,
Gevaert K.
,
Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]