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Index > Protein center > ASRGL1(Gene name) > Human
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  • ASRGL1 (Gene name),
  • L-asparaginase (Protein name ),  ASGL1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ASRGL1(ALP;CRASH);
    Protein name:
    L-asparaginase;
    Alternative:
    L-asparagine amidohydrolase;Asparaginase-like protein 1;L-asparagine amidohydrolase;Isoaspartyl dipeptidase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Acts in asparagine catabolism. May be involved in astroglial production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions.
    Subcellular Location:
    Cytoplasm Midpiece of sperm tail.
    Protein Attributes:
    Sequence length:
    308
    Sequence:
    50:
    MNPIVVVHGG | GAGPISKDRK | ERVHQGMVRA | ATVGYGILRE | GGSAVDAVEG | 
    100:
    AVVALEDDPE | FNAGCGSVLN | TNGEVEMDAS | IMDGKDLSAG | AVSAVQCIAN | 
    150:
    PIKLARLVME | KTPHCFLTDQ | GAAQFAAAMG | VPEIPGEKLV | TERNKKRLEK | 
    200:
    EKHEKGAQKT | DCQKNLGTVG | AVALDCKGNV | AYATSTGGIV | NKMVGRVGDS | 
    250:
    PCLGAGGYAD | NDIGAVSTTG | HGESILKVNL | ARLTLFHIEQ | GKTVEEAADL | 
    300:
    SLGYMKSRVK | GLGGLIVVSK | TGDWVAKWTS | TSMPWAAAKD | GKLHFGIDPD | 
    308:
    DTTITDLP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    UniGene:
    String:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human L-asparaginase
    MSDS:
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    ELISA Kit for Human L-asparaginase
    Cat.:
    E14138h
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    Packing:
    96T
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    ELISA Kit for Human L-asparaginase
    MSDS:
    Please sign in first.
    ELISA Kit for Human L-asparaginase
    Cat.:
    E14138m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human L-asparaginase
    MSDS:
    Please sign in first.
    CLIA Kit for Human L-asparaginase
    Cat.:
    U14138h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human L-asparaginase
    MSDS:
    Please sign in first.
    CLIA Kit for Human L-asparaginase
    Cat.:
    U14138m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human L-asparaginase
    Polyclonal Antibody for Human L-asparaginase
    Polyclonal Antibody for Human L-asparaginase
    Polyclonal Antibody for Human L-asparaginase
    Monoclonal Antibody for Human L-asparaginase
    Monoclonal Antibody for Human L-asparaginase
    Monoclonal Antibody for Human L-asparaginase
    Monoclonal Antibody for Human L-asparaginase
    Protein for Human L-asparaginase
    Protein for Human L-asparaginase
    Protein for Human L-asparaginase
    Protein for Human L-asparaginase

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    Linearity
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    References
    1. 1.
      "A novel asparaginase-like protein is a sperm autoantigen in rats."
      Bush L.A. , Herr J.C. , Wolkowicz M. , Sherman N.E. , Shore A. , Flickinger C.J.
      Mol. Reprod. Dev.62:233-247(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;SUBCELLULAR LOCATION
      tissue: Testis.
    2. 2.
      "Identification of CRASH, a gene deregulated in gynecological tumors."
      Evtimova V. , Zeillinger R. , Kaul S. , Weidle U.H.
      Int. J. Oncol.24:33-41(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;INDUCTION
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Corpus callosum.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Eye.
      tissue: Lung.
      tissue: Skin.
    6. 6.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    7. 7.
      "The human asparaginase-like protein 1 hASRGL1 is an Ntn hydrolase with beta-aspartyl peptidase activity."
      Cantor J.R. , Stone E.M. , Chantranupong L. , Georgiou G.
      Biochemistry48:11026-11031(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES;ACTIVE SITE;MUTAGENESIS OF THR-168;IDENTIFICATION BY MASS SPECTROMETRY;AUTOCATALYTIC CLEAVAGE
    8. 8.
      "Structures of apo and product-bound human L-asparaginase: insights into the mechanism of autoproteolysis and substrate hydrolysis."
      Nomme J. , Su Y. , Konrad M. , Lavie A.
      Biochemistry51:6816-6826(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEXES WITH ASPARTATE;ACTIVE SITE;SUBUNIT;ENZYME REGULATION;AUTOCATALYTIC CLEAVAGE
    9. 9.
      "Uncoupling intramolecular processing and substrate hydrolysis in the N-terminal nucleophile hydrolase hASRGL1 by circular permutation."
      Li W. , Cantor J.R. , Yogesha S.D. , Yang S. , Chantranupong L. , Liu J.Q. , Agnello G. , Georgiou G. , Stone E.M. , Zhang Y.
      ACS Chem. Biol.7:1840-1847(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS);CATALYTIC ACTIVITY;MUTAGENESIS OF THR-168;SUBUNIT
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