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Index > Protein center > ATP2A3(Gene name) > Human
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  • ATP2A3 (Gene name),
  • Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (Protein name ),  AT2A3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    ATP2A3;
    Protein name:
    Sarcoplasmic/endoplasmic reticulum calcium ATPase 3(SERCA3;SR Ca(2+)-ATPase 3);
    Alternative:
    Calcium pump 3;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
    Subcellular Location:
    Nucleus membrane Multi-pass membrane protein Endoplasmic reticulum membrane Multi-pass membrane protein Sarcoplasmic reticulum membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    1043
    Sequence:
    50:
    MEAAHLLPAA | DVLRHFSVTA | EGGLSPAQVT | GARERYGPNE | LPSEEGKSLW | 
    100:
    ELVLEQFEDL | LVRILLLAAL | VSFVLAWFEE | GEETTTAFVE | PLVIMLILVA | 
    150:
    NAIVGVWQER | NAESAIEALK | EYEPEMGKVI | RSDRKGVQRI | RARDIVPGDI | 
    200:
    VEVAVGDKVP | ADLRLIEIKS | TTLRVDQSIL | TGESVSVTKH | TEAIPDPRAV | 
    250:
    NQDKKNMLFS | GTNITSGKAV | GVAVATGLHT | ELGKIRSQMA | AVEPERTPLQ | 
    300:
    RKLDEFGRQL | SHAISVICVA | VWVINIGHFA | DPAHGGSWLR | GAVYYFKIAV | 
    350:
    ALAVAAIPEG | LPAVITTCLA | LGTRRMARKN | AIVRSLPSVE | TLGCTSVICS | 
    400:
    DKTGTLTTNQ | MSVCRMFVVA | EADAGSCLLH | EFTISGTTYT | PEGEVRQGDQ | 
    450:
    PVRCGQFDGL | VELATICALC | NDSALDYNEA | KGVYEKVGEA | TETALTCLVE | 
    500:
    KMNVFDTDLQ | ALSRVERAGA | CNTVIKQLMR | KEFTLEFSRD | RKSMSVYCTP | 
    550:
    TRPHPTGQGS | KMFVKGAPES | VIERCSSVRV | GSRTAPLTPT | SREQILAKIR | 
    600:
    DWGSGSDTLR | CLALATRDAP | PRKEDMELDD | CSKFVQYETD | LTFVGCVGML | 
    650:
    DPPRPEVAAC | ITRCYQAGIR | VVMITGDNKG | TAVAICRRLG | IFGDTEDVAG | 
    700:
    KAYTGREFDD | LSPEQQRQAC | RTARCFARVE | PAHKSRIVEN | LQSFNEITAM | 
    750:
    TGDGVNDAPA | LKKAEIGIAM | GSGTAVAKSA | AEMVLSDDNF | ASIVAAVEEG | 
    800:
    RAIYSNMKQF | IRYLISSNVG | EVVCIFLTAI | LGLPEALIPV | QLLWVNLVTD | 
    850:
    GLPATALGFN | PPDLDIMEKL | PRSPREALIS | GWLFFRYLAI | GVYVGLATVA | 
    900:
    AATWWFVYDA | EGPHINFYQL | RNFLKCSEDN | PLFAGIDCEV | FESRFPTTMA | 
    950:
    LSVLVTIEMC | NALNSVSENQ | SLLRMPPWMN | PWLLVAVAMS | MALHFLILLV | 
    1000:
    PPLPLIFQVT | PLSGRQWVVV | LQISLPVILL | DEALKYLSRN | HMHACLYPGL | 
    1043:
    LRTVSQAWSR | QPLTTSWTPD | HTGRNEPEVS | AGNRVESPVC | TSD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    String:
    Pfam:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human SERCA3
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    ELISA Kit for Human SERCA3
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    ELISA Kit for Human SERCA3
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    CLIA Kit for Human SERCA3
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    CLIA Kit for Human SERCA3
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    U9232h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human SERCA3
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    U9232r
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    Polyclonal Antibody for Human SERCA3
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    P9232Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human SERCA3
    Polyclonal Antibody for Human SERCA3
    Polyclonal Antibody for Human SERCA3
    Polyclonal Antibody for Human SERCA3
    Cat.:
    P9232Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human SERCA3
    Monoclonal Antibody for Human SERCA3
    Monoclonal Antibody for Human SERCA3
    Monoclonal Antibody for Human SERCA3
    Monoclonal Antibody for Human SERCA3
    Protein for Human SERCA3
    Protein for Human SERCA3
    Protein for Human SERCA3
    Protein for Human SERCA3
    Protein for Human SERCA3

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    Linearity
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    References
    1. 1.
      "cDNA cloning, expression and chromosomal localization of the human sarco/endoplasmic reticulum Ca(2+)-ATPase 3 gene."
      Dode L. , Wuytack F. , Kools P.F.J. , Baba-Aissa F. , Raeymaekers L. , Brik F. , van de Ven W.J.M. , Casteels R.
      Biochem. J.318:689-699(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM SERCA3A)
      tissue: Leukemic T-cell.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    3. 3.
      "Structure of the human sarco/endoplasmic reticulum Ca2+-ATPase 3 gene. Promoter analysis and alternative splicing of the SERCA3 pre-mRNA."
      Dode L. , De Greef C. , Mountian I. , Attard M. , Town M.M. , Casteels R. , Wuytack F.
      J. Biol. Chem.273:13982-13994(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS SERCA3B AND SERCA3C)
    4. 4.
      "Functional characterization of alternatively spliced human SERCA3 transcripts."
      Poch E. , Leach S. , Snape S. , Cacic T. , McLennan D.H. , Lytton J.
      Am. J. Physiol.275:C1449-C1458(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SERCA3A; SERCA3C AND SERCA3G)
      tissue: Kidney.
      tissue: Leukemic T-cell.
    5. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SERCA3A)
      tissue: Ovary.
    7. 8.
      "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
      Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-14;ACETYLATION AT MET-1
      tissue: Platelet.
    8. 9.
      Bienvenut W.V. , Claeys D.
      Submitted (2005-11) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-33; 111-120; 219-234; 482-489; 516-524; 549-560 AND 657-667;ACETYLATION AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Platelet.
    9. 10.
      "A sarco/endoplasmic reticulum Ca(2+)-ATPase 3-type Ca2+ pump is expressed in platelets, in lymphoid cells, and in mast cells."
      Wuytack F. , Papp B. , Verboomen H. , Raeymaekers L. , Dode L. , Bobe R. , Enouf J. , Bokkala S. , Authi K.S. , Casteels R.
      J. Biol. Chem.269:1410-1416(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 454-509
    10. 11.
      "Three novel sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 3 isoforms. Expression, regulation, and function of the membranes of the SERCA3 family."
      Martin V. , Bredoux R. , Corvazier E. , Van Gorp R. , Kovacs T. , Gelebart P. , Enouf J.
      J. Biol. Chem.277:24442-24452(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 892-1043 (ISOFORMS SERCA3D AND SERCA3E);ALTERNATIVE SPLICING;FUNCTION;TISSUE SPECIFICITY
    11. 12.
      "Identification, expression, function, and localization of a novel (sixth) isoform of the human sarco/endoplasmic reticulum Ca2+ATPase 3 gene."
      Bobe R. , Bredoux R. , Corvazier E. , Andersen J.P. , Clausen J.D. , Dode L. , Kovacs T. , Enouf J.
      J. Biol. Chem.279:24297-24306(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 892-1043 (ISOFORM SERCA3F);ALTERNATIVE SPLICING;FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    12. 13.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-662;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    13. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] HIS-674
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