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Index > Protein center > ATF1(Gene name) > Human
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  • ATF1 (Gene name),
  • Cyclic AMP-dependent transcription factor ATF-1 (Protein name ),  ATF1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ATF1;
    Protein name:
    Cyclic AMP-dependent transcription factor ATF-1(cAMP-dependent transcription factor ATF-1);
    Alternative:
    Protein TREB36;Activating transcription factor 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds DNA as a dimer. Interacts with HIPK2 and CDK3.
    Function:
    This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    271
    Sequence:
    50:
    MEDSHKSTTS | ETAPQPGSAV | QGAHISHIAQ | QVSSLSESEE | SQDSSDSIGS | 
    100:
    SQKAHGILAR | RPSYRKILKD | LSSEDTRGRK | GDGENSGVSA | AVTSMSVPTP | 
    150:
    IYQTSSGQYI | AIAPNGALQL | ASPGTDGVQG | LQTLTMTNSG | STQQGTTILQ | 
    200:
    YAQTSDGQQI | LVPSNQVVVQ | TASGDMQTYQ | IRTTPSATSL | PQTVVMTSPV | 
    250:
    TLTSQTTKTD | DPQLKREIRL | MKNREAAREC | RRKKKEYVKC | LENRVAVLEN | 
    271:
    QNKTLIEELK | TLKDLYSNKS | V
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    MIM:
    String:
    Pfam:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human cAMP-dependent transcription factor ATF-1
    Cat.:
    E1346b
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human cAMP-dependent transcription factor ATF-1
    Cat.:
    E1346h
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    Packing:
    96T
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    ELISA Kit for Human cAMP-dependent transcription factor ATF-1
    Cat.:
    E1346m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human cAMP-dependent transcription factor ATF-1
    Cat.:
    U1346h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human cAMP-dependent transcription factor ATF-1
    Cat.:
    U1346b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human cAMP-dependent transcription factor ATF-1
    Cat.:
    U1346m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human cAMP-dependent transcription factor ATF-1
    Cat.:
    P1346Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human cAMP-dependent transcription factor ATF-1
    Cat.:
    P1346Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human cAMP-dependent transcription factor ATF-1
    Monoclonal Antibody for Human cAMP-dependent transcription factor ATF-1
    Monoclonal Antibody for Human cAMP-dependent transcription factor ATF-1
    Monoclonal Antibody for Human cAMP-dependent transcription factor ATF-1
    Protein for Human cAMP-dependent transcription factor ATF-1
    Protein for Human cAMP-dependent transcription factor ATF-1
    Protein for Human cAMP-dependent transcription factor ATF-1

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    Linearity
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    References
    1. 1.
      "Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain."
      Yoshimura T. , Fujisawa J. , Yoshida M.
      EMBO J.9:2537-2542(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "The cAMP-regulated enhancer-binding protein ATF-1 activates transcription in response to cAMP-dependent protein kinase A."
      Rehfuss R.P. , Walton K.M. , Loriaux M.M. , Goodman R.H.
      J. Biol. Chem.266:18431-18434(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    4. 4.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Bone marrow.
    6. 6.
      "Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers."
      Hai T. , Liu F. , Coukos W.J. , Green M.R.
      Genes Dev.3:2083-2090(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 39-271 (ISOFORM 1)
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    8. 8.
      "Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF-1 genes induced by a chromosomal translocation involving bands 12q13 and 16p11."
      Waters B.L. , Panagopoulos I. , Allen E.F.
      Cancer Genet. Cytogenet.121:109-116(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-246 (ISOFORM 1);CHROMOSOMAL TRANSLOCATION WITH FUS;ASSOCIATION WITH ANGIOMATOID FIBROUS HISTIOCYTOMA
    9. 9.
      "Regulation of activating transcription factor-1 and the cAMP response element-binding protein by Ca2+/calmodulin-dependent protein kinases type I, II, and IV."
      Sun P. , Lou L. , Maurer R.A.
      J. Biol. Chem.271:3066-3073(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-63;PHOSPHORYLATION BY CAMK1
    10. 10.
      "Fusion of the EWSR1 and ATF1 genes without expression of the MITF-M transcript in angiomatoid fibrous histiocytoma."
      Hallor K.H. , Mertens F. , Jin Y. , Meis-Kindblom J.M. , Kindblom L.-G. , Behrendtz M. , Kalen A. , Mandahl N. , Panagopoulos I.
      Genes Chromosomes Cancer44:97-102(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH EWSR1;ASSOCIATION WITH ANGIOMATOID FIBROUS HISTIOCYTOMA
    11. 11.
      "Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation."
      Zheng D. , Cho Y.-Y. , Lau A.T.Y. , Zhang J. , Ma W.-Y. , Bode A.M. , Dong Z.
      Cancer Res.68:7650-7660(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT SER-63 BY CDK3;INTERACTION WITH CDK3;MUTAGENESIS OF SER-63
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-198;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 13.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-198;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    14. 14.
      "Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress."
      Hailemariam K. , Iwasaki K. , Huang B.W. , Sakamoto K. , Tsuji Y.
      J. Cell Sci.123:3863-3871(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS REPRESSOR;PHOSPHORYLATION AT SER-198 BY HIPK2;INTERACTION WITH HIPK2
    15. 15.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
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