Gene name:
ATF2 (CREB2;CREBP1) ;
Protein name:
Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) ;
Alternative:
Cyclic AMP-responsive element-binding protein 2 (CREB-2;cAMP-responsive element-binding protein 2) ;Activating transcription factor 2 ;cAMP response element-binding protein CRE-BP1 ;HB16 ;cAMP response element-binding protein CRE-BP1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Interacts with SMAD3 and SMAD4. Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity.
Function:
Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MKFKLHVNSA | RQYKDLWNMS | DDKPFLCTAP | GCGQRFTNED | HLAVHKHKHE |
100:
MTLKFGPARN | DSVIVADQTP | TPTRFLKNCE | EVGLFNELAS | PFENEFKKAS |
150:
EDDIKKMPLD | LSPLATPIIR | SKIEEPSVVE | TTHQDSPLPH | PESTTSDEKE |
200:
VPLAQTAQPT | SAIVRPASLQ | VPNVLLTSSD | SSVIIQQAVP | SPTSSTVITQ |
250:
APSSNRPIVP | VPGPFPLLLH | LPNGQTMPVA | IPASITSSNV | HVPAAVPLVR |
300:
PVTMVPSVPG | IPGPSSPQPV | QSEAKMRLKA | ALTQQHPPVT | NGDTVKGHGS |
350:
GLVRTQSEES | RPQSLQQPAT | STTETPASPA | HTTPQTQSTS | GRRRRAANED |
400:
PDEKRRKFLE | RNRAAASRCR | QKRKVWVQSL | EKKAEDLSSL | NGQLQSEVTL |
450:
LRNEVAQLKQ | LLLAHKDCPV | TAMQKKSGYH | TADKDDSSED | ISVPSSPHTE |
500:
AIQHSSVSTS | NGVSSTSKAE | AVATSVLTQM | ADQSTEPALS | QIVMAPSSQS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Chicken
Human
Mouse
ELISA Kit for Human cAMP-dependent transcription factor ATF-2
ELISA Kit for Human cAMP-dependent transcription factor ATF-2
ELISA Kit for Human cAMP-dependent transcription factor ATF-2
ELISA Kit for Human cAMP-dependent transcription factor ATF-2
CLIA Kit for Human cAMP-dependent transcription factor ATF-2
CLIA Kit for Human cAMP-dependent transcription factor ATF-2
CLIA Kit for Human cAMP-dependent transcription factor ATF-2
CLIA Kit for Human cAMP-dependent transcription factor ATF-2
Polyclonal Antibody for Human cAMP-dependent transcription factor ATF-2
Polyclonal Antibody for Human cAMP-dependent transcription factor ATF-2
Polyclonal Antibody for Human cAMP-dependent transcription factor ATF-2
Polyclonal Antibody for Human cAMP-dependent transcription factor ATF-2
Monoclonal Antibody for Human cAMP-dependent transcription factor ATF-2
Monoclonal Antibody for Human cAMP-dependent transcription factor ATF-2
Monoclonal Antibody for Human cAMP-dependent transcription factor ATF-2
Monoclonal Antibody for Human cAMP-dependent transcription factor ATF-2
Protein for Human cAMP-dependent transcription factor ATF-2
Protein for Human cAMP-dependent transcription factor ATF-2
Protein for Human cAMP-dependent transcription factor ATF-2
Protein for Human cAMP-dependent transcription factor ATF-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Fetal brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
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Thymus .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8)
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Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 5; 6 AND 7)
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Nature434:724-731(2005)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4)
tissue :
Brain .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 211-505 (ISOFORMS 1/2)
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION BY CAMK4
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT THR-69 AND THR-71
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH UTF1
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;CATALYTIC ACTIVITY;PHOSPHORYLATION;MUTAGENESIS OF THR-69 AND THR-71
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT THR-69 AND THR-71
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-62 AND THR-73;SUBCELLULAR LOCATION
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH NBN AND MRE11A;SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-490 AND SER-498
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION AT LYS-357 AND LYS-374;IDENTIFICATION BY MASS SPECTROMETRY
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH CUL3 AND KAT5;SUBCELLULAR LOCATION
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-328;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-69 AND SER-112;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT THR-69; THR-71; SER-121; SER-340 AND SER-367;SUBCELLULAR LOCATION
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-69; THR-71 AND SER-112;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
24.
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Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-69; THR-71; SER-112 AND THR-116;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT THR-71;SUBCELLULAR LOCATION;MUTAGENESIS OF THR-71
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-69; THR-71; SER-90 AND SER-112;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH HK1/VDAC1 COMPLEX;PHOSPHORYLATION AT THR-52
28.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;NUCLEAR EXPORT SIGNAL;INTERACTION WITH XPO1;HETERODIMERIZATION WITH JUN
29.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
30.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 19-56
31.
"The consensus coding sequences of human breast and colorectal cancers."
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Science314:268-274(2006)
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT [LARGE SCALE ANALYSIS] HIS-352