ATG12 ELISA Kit for Human(Homo sapiens) | EIAab.comATG12 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > ATG12(Gene name) > Human

ATG12 (Gene name),

Ubiquitin-like protein ATG12 (Protein name ), ATG12_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ATG12(APG12;APG12L);

Protein name:

Ubiquitin-like protein ATG12;

Alternative:

Autophagy-related protein 12(APG12-like);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Ubiquitin-like protein required for autophagy. Conjugated to ATG3 and ATG5.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

140

Sequence:

50:

100:

140:

FIYVNQSFAP | SPDQEVGTLY | ECFGSDGKLV | LHYCKSQAWG |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

O94817

MIM:

609608

String:

O94817

KEGG:

hsa:9140

UniGene:

Hs.264482

Pfam:

PF04110

STRING:

9606.ENSP00000274459

Uniprot:

O94817

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ELISA Kit for Human Ubiquitin-like protein ATG12

Cat.:

E2478h

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96T

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ELISA Kit for Human Ubiquitin-like protein ATG12

Cat.:

E2478m

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Looking for manual.

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96T

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ELISA Kit for Human Ubiquitin-like protein ATG12

Cat.:

E2478r

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96T

ELISA Kit for Human Ubiquitin-like protein ATG12

Cat.:

E2478b

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96T

CLIA Kit for Human Ubiquitin-like protein ATG12

Cat.:

U2478m

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96T

CLIA Kit for Human Ubiquitin-like protein ATG12

Cat.:

U2478b

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96T

CLIA Kit for Human Ubiquitin-like protein ATG12

Cat.:

U2478h

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MSDS:

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Packing:

96T

CLIA Kit for Human Ubiquitin-like protein ATG12

Cat.:

U2478r

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96T

Polyclonal Antibody for Human Ubiquitin-like protein ATG12

Cat.:

P2478Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Ubiquitin-like protein ATG12

Cat.:

P2478Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Ubiquitin-like protein ATG12

Cat.:

P2478Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Ubiquitin-like protein ATG12

Monoclonal Antibody for Human Ubiquitin-like protein ATG12

Protein for Human Ubiquitin-like protein ATG12

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy."
Mizushima N. , Sugita H. , Yoshimori T. , Ohsumi Y.
J. Biol. Chem.273:33889-33892(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CONJUGATION TO ATG5;TISSUE SPECIFICITY
2.

"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J. , Martin J. , Terry A. , Couronne O. , Grimwood J. , Lowry S. , Gordon L.A. , Scott D. , Xie G. , Huang W. , Hellsten U. , Tran-Gyamfi M. , She X. , Prabhakar S. , Aerts A. , Altherr M. , Bajorek E. , Black S. , more...
Nature431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Brain.
tissue: Ovary.
4.

"The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3."
Tanida I. , Tanida-Miyake E. , Ueno T. , Kominami E.
J. Biol. Chem.276:1701-1706(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATG7;CONJUGATION TO ATG5
5.

"Mammalian Apg12p, but not the Apg12p.Apg5p conjugate, facilitates LC3 processing."
Tanida I. , Nishitani T. , Nemoto T. , Ueno T. , Kominami E.
Biochem. Biophys. Res. Commun.296:1164-1170(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATG3;CONJUGATION TO ATG5;FUNCTION
6.

"Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p."
Tanida I. , Tanida-Miyake E. , Komatsu M. , Ueno T. , Kominami E.
J. Biol. Chem.277:13739-13744(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATG3;CONJUGATION TO ATG5
7.

"Stimulation of ATG12-ATG5 conjugation by ribonucleic acid."
Shao Y. , Gao Z. , Feldman T. , Jiang X.
Autophagy3:10-16(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CONJUGATION TO ATG5
8.

"Mitochondrial DNA deletions and chloramphenicol treatment stimulate the autophagic transcript ATG12."
Prigione A. , Cortopassi G.
Autophagy3:377-380(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
9.

"The Atg5-Atg12 conjugate associates with innate antiviral immune responses."
Jounai N. , Takeshita F. , Kobiyama K. , Sawano A. , Miyawaki A. , Xin K.Q. , Ishii K.J. , Kawai T. , Akira S. , Suzuki K. , Okuda K.
Proc. Natl. Acad. Sci. U.S.A.104:14050-14055(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INNATE IMMUNE RESPONSE;INTERACTION WITH MAVS; MGA AND RARRES3
10.

"The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series."
Geng J. , Klionsky D.J.
EMBO Rep.9:859-864(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN
11.

"Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes."
Kim P.K. , Hailey D.W. , Mullen R.T. , Lippincott-Schwartz J.
Proc. Natl. Acad. Sci. U.S.A.105:20567-20574(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"Induction of autophagy promotes fusion of multivesicular bodies with autophagic vacuoles in k562 cells."
Fader C.M. , Sanchez D. , Furlan M. , Colombo M.I.
Traffic9:230-250(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"Nicotinamide enhances mitochondria quality through autophagy activation in human cells."
Kang H.T. , Hwang E.S.
Aging Cell8:426-438(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
14.

"Effect of Helicobacter pylori's vacuolating cytotoxin on the autophagy pathway in gastric epithelial cells."
Terebiznik M.R. , Raju D. , Vazquez C.L. , Torbricki K. , Kulkarni R. , Blanke S.R. , Yoshimori T. , Colombo M.I. , Jones N.L.
Autophagy5:370-379(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

"Regulation of autophagy by the p300 acetyltransferase."
Lee I.H. , Finkel T.
J. Biol. Chem.284:6322-6328(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION
16.

"The autophagy machinery is required to initiate hepatitis C virus replication."
Dreux M. , Gastaminza P. , Wieland S.F. , Chisari F.V.
Proc. Natl. Acad. Sci. U.S.A.106:14046-14051(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN VIRAL REPLICATION
17.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate."
Chen D. , Fan W. , Lu Y. , Ding X. , Chen S. , Zhong Q.
Mol. Cell45:629-641(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TECPR1;SUBCELLULAR LOCATION
19.

"Structure of the human ATG12-ATG5 conjugate required for LC3 lipidation in autophagy."
Otomo C. , Metlagel Z. , Takaesu G. , Otomo T.
Nat. Struct. Mol. Biol.20:59-66(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 52-140 IN COMPLEX WITH ATG5 AND ATG16L;INTERACTION WITH ATG3;FUNCTION;MUTAGENESIS OF LYS-54; VAL-62; GLY-63; LYS-72; TRP-73; PHE-108; ASP-113; CYS-122; PHE-123; ALA-138 AND TRP-139

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