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Index > Protein center > ATG5(Gene name) > Human
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  • ATG5 (Gene name),
  • Autophagy protein 5 (Protein name ),  ATG5_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    ATG5(APG5L;ASP);
    Protein name:
    Autophagy protein 5;
    Alternative:
    APG5-like;Apoptosis-specific protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity.
    Subcellular Location:
    Cytoplasm Colocalizes with nonmuscle actin.
    Protein Attributes:
    Sequence length:
    275
    Sequence:
    50:
    MTDDKDVLRD | VWFGRIPTCF | TLYQDEITER | EAEPYYLLLP | RVSYLTLVTD | 
    100:
    KVKKHFQKVM | RQEDISEIWF | EYEGTPLKWH | YPIGLLFDLL | ASSSALPWNI | 
    150:
    TVHFKSFPEK | DLLHCPSKDA | IEAHFMSCMK | EADALKHKSQ | VINEMQKKDH | 
    200:
    KQLWMGLQND | RFDQFWAINR | KLMEYPAEEN | GFRYIPFRIY | QTTTERPFIQ | 
    250:
    KLFRPVAADG | QLHTLGDLLK | EVCPSAIDPE | DGEKKNQVMI | HGIEPMLETP | 
    275:
    LQWLSEHLSY | PDNFLHISII | PQPTD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    UniGene:
    String:
    Pfam:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Autophagy protein 5
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    E15032h
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    96T
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    ELISA Kit for Human Autophagy protein 5
    MSDS:
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    ELISA Kit for Human Autophagy protein 5
    MSDS:
    Please sign in first.
    ELISA Kit for Human Autophagy protein 5
    MSDS:
    Please sign in first.
    ELISA Kit for Human Autophagy protein 5
    Cat.:
    E15032m
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human Autophagy protein 5
    MSDS:
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    CLIA Kit for Human Autophagy protein 5
    MSDS:
    Please sign in first.
    CLIA Kit for Human Autophagy protein 5
    MSDS:
    Please sign in first.
    CLIA Kit for Human Autophagy protein 5
    MSDS:
    Please sign in first.
    CLIA Kit for Human Autophagy protein 5
    Cat.:
    U15032h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Autophagy protein 5
    Polyclonal Antibody for Human Autophagy protein 5
    Polyclonal Antibody for Human Autophagy protein 5
    Polyclonal Antibody for Human Autophagy protein 5
    Polyclonal Antibody for Human Autophagy protein 5
    Monoclonal Antibody for Human Autophagy protein 5
    Monoclonal Antibody for Human Autophagy protein 5
    Monoclonal Antibody for Human Autophagy protein 5
    Monoclonal Antibody for Human Autophagy protein 5
    Monoclonal Antibody for Human Autophagy protein 5
    Protein for Human Autophagy protein 5
    Protein for Human Autophagy protein 5
    Protein for Human Autophagy protein 5
    Protein for Human Autophagy protein 5
    Protein for Human Autophagy protein 5

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    References
    1. 1.
      "Homology between a human apoptosis specific protein and the product of APG5, a gene involved in autophagy in yeast."
      Hammond E.M. , Brunet C.L. , Johnson G.D. , Parkhill J. , Milner A.E. , Brady G. , Gregory C.D. , Grand R.J.A.
      FEBS Lett.425:391-395(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
      tissue: Fetal liver.
    2. 2.
      "A novel splicing isoform of human APG5."
      Chen Y. , Piao Y.J. , Jiang Y.
      Submitted (2000-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT)
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SHORT)
      tissue: Fetal brain.
    4. 4.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
      tissue: Endometrium.
      tissue: Placenta.
    6. 6.
      "A novel protein expressed in mammalian cells undergoing apoptosis."
      Grand R.J.A. , Milner A.E. , Mustoe T. , Johnson G.D. , Owen D. , Grant M.L. , Gregory C.D.
      Exp. Cell Res.218:439-451(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN APOPTOSIS
    7. 7.
      "A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy."
      Mizushima N. , Sugita H. , Yoshimori T. , Ohsumi Y.
      J. Biol. Chem.273:33889-33892(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CONJUGATION TO ATG12 AT LYS-130;MUTAGENESIS OF LYS-130
    8. 8.
      "The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3."
      Tanida I. , Tanida-Miyake E. , Ueno T. , Kominami E.
      J. Biol. Chem.276:1701-1706(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CONJUGATION TO ATG12
    9. 9.
      "Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells."
      Mizushima N. , Yamamoto A. , Hatano M. , Kobayashi Y. , Kabeya Y. , Suzuki K. , Tokuhisa T. , Ohsumi Y. , Yoshimori T.
      J. Cell Biol.152:657-668(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CONJUGATION TO ATG12;SUBCELLULAR LOCATION
      tissue: Embryonic stem cell.
    10. 10.
      "Mammalian Apg12p, but not the Apg12p.Apg5p conjugate, facilitates LC3 processing."
      Tanida I. , Nishitani T. , Nemoto T. , Ueno T. , Kominami E.
      Biochem. Biophys. Res. Commun.296:1164-1170(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATG3;CONJUGATION TO ATG12;FUNCTION
    11. 11.
      "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p."
      Tanida I. , Tanida-Miyake E. , Komatsu M. , Ueno T. , Kominami E.
      J. Biol. Chem.277:13739-13744(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATG3;CONJUGATION TO ATG12
    12. 12.
      "Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death."
      Pyo J.O. , Jang M.H. , Kwon Y.K. , Lee H.J. , Jun J.I. , Woo H.N. , Cho D.H. , Choi B. , Lee H. , Kim J.H. , Mizushima N. , Oshumi Y. , Jung Y.K.
      J. Biol. Chem.280:20722-20729(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH FADD
    13. 13.
      "Stimulation of ATG12-ATG5 conjugation by ribonucleic acid."
      Shao Y. , Gao Z. , Feldman T. , Jiang X.
      Autophagy3:10-16(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CONJUGATION TO ATG12
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INNATE IMMUNE RESPONSE;INTERACTION WITH MAVS; MGA AND RARRES3
    15. 15.
      "Regulation of autophagy by the p300 acetyltransferase."
      Lee I.H. , Finkel T.
      J. Biol. Chem.284:6322-6328(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION BY EP300
    16. 16.
      "Autophagy protein ATG5 interacts transiently with the hepatitis C virus RNA polymerase (NS5B) early during infection."
      Guevin C. , Manna D. , Belanger C. , Konan K.V. , Mak P. , Labonte P.
      Virology405:1-7(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH HEPATITIS C VIRUS PROTEIN NS5B
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TECPR1
    19. 19.
      "Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan."
      Mai S. , Muster B. , Bereiter-Hahn J. , Jendrach M.
      Autophagy8:47-62(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    20. 20.
      "A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate."
      Chen D. , Fan W. , Lu Y. , Ding X. , Chen S. , Zhong Q.
      Mol. Cell45:629-641(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TECPR1
    21. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    22. 22.
      "Structure of the human ATG12-ATG5 conjugate required for LC3 lipidation in autophagy."
      Otomo C. , Metlagel Z. , Takaesu G. , Otomo T.
      Nat. Struct. Mol. Biol.20:59-66(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) IN CONJUGATION WITH ATG12
    23. 23.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] MET-58
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