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Index > Protein center > AXIN1(Gene name) > Human
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  • AXIN1 (Gene name),
  • Axin-1 (Protein name ),  AXIN1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    AXIN1(AXIN);
    Protein name:
    Axin-1;
    Alternative:
    Axis inhibition protein 1(hAxin);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer (By similarity). Component of the beta-catenin destruction complex, containing at least, CTNNB1, an axin and GSK3B, that regulates CTNNB1 protein levels through phosphorylation and ubiquitination. Interacts with CTNNB1 (via the armadillo repeats 2-7). Interacts with GSK3B; the interaction hyperphosphorylates CTNNB1 leading to its ubiquitination and destruction. Component of the AXIN1-HIPK2-TP53 complex. Interacts directly in the complex with TP53 and HIPK2. Interacts with DAXX; the interaction stimulates the interaction of DAXX with TP53, stimulates 'Ser-46' phosphorylation of TP53 and induces cell death on UV irradiation. Also binds APC, SMAD6, SMAD7 and RNF111. Interacts with DIXDC1; prevents interaction with MAP3K1. Interacts with MAP3K4. Interacts with ANKRD6 and AIDA (By similarity). Interacts with MDFI; the interaction decreases AXIN1-mediated JUN N-terminal kinase (JNK) activation. Interacts with MDFIC; the interaction inhibits beta-cateninin-mediated signaling and AXIN1-mediated JUN N-terminal kinase (JNK) activation. Interacts with LRP5 (via its phosphorylated PPPSP motifs); the interaction is stimulated by WNT1 and GSK3B and activates beta-catenin signaling. Interacts (via the C-terminal) with PPP1CA; the interaction dephosphorylates AXIN1 and regulates interaction with GSK3B. Interacts with PPP2CA; the interaction dephosphorylates AXIN1. Interacts with MACF1 (By similarity). Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B.
    Function:
    Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.
    Subcellular Location:
    Cytoplasm Nucleus Cell membrane MACF1 is required for its translocation to cell membrane (By similarity). On UV irradiation, translocates to the nucleus and colocalizes with DAAX.
    Protein Attributes:
    Sequence length:
    862
    Sequence:
    50:
    MNIQEQGFPL | DLGASFTEDA | PRPPVPGEEG | ELVSTDPRPA | SYSFCSGKGV | 
    100:
    GIKGETSTAT | PRRSDLDLGY | EPEGSASPTP | PYLKWAESLH | SLLDDQDGIS | 
    150:
    LFRTFLKQEG | CADLLDFWFA | CTGFRKLEPC | DSNEEKRLKL | ARAIYRKYIL | 
    200:
    DNNGIVSRQT | KPATKSFIKG | CIMKQLIDPA | MFDQAQTEIQ | ATMEENTYPS | 
    250:
    FLKSDIYLEY | TRTGSESPKV | CSDQSSGSGT | GKGISGYLPT | LNEDEEWKCD | 
    300:
    QDMDEDDGRD | AAPPGRLPQK | LLLETAAPRV | SSSRRYSEGR | EFRYGSWREP | 
    350:
    VNPYYVNAGY | ALAPATSAND | SEQQSLSSDA | DTLSLTDSSV | DGIPPYRIRK | 
    400:
    QHRREMQESV | QVNGRVPLPH | IPRTYRVPKE | VRVEPQKFAE | ELIHRLEAVQ | 
    450:
    RTREAEEKLE | ERLKRVRMEE | EGEDGDPSSG | PPGPCHKLPP | APAWHHFPPR | 
    500:
    CVDMGCAGLR | DAHEENPESI | LDEHVQRVLR | TPGRQSPGPG | HRSPDSGHVA | 
    550:
    KMPVALGGAA | SGHGKHVPKS | GAKLDAAGLH | HHRHVHHHVH | HSTARPKEQV | 
    600:
    EAEATRRAQS | SFAWGLEPHS | HGARSRGYSE | SVGAAPNASD | GLAHSGKVGV | 
    650:
    ACKRNAKKAE | SGKSASTEVP | GASEDAEKNQ | KIMQWIIEGE | KEISRHRRTG | 
    700:
    HGSSGTRKPQ | PHENSRPLSL | EHPWAGPQLR | TSVQPSHLFI | QDPTMPPHPA | 
    750:
    PNPLTQLEEA | RRRLEEEEKR | ASRAPSKQRY | VQEVMRRGRA | CVRPACAPVL | 
    800:
    HVVPAVSDME | LSETETRSQR | KVGGGSAQPC | DSIVVAYYFC | GEPIPYRTLV | 
    850:
    RGRAVTLGQF | KELLTKKGSY | RYYFKKVSDE | FDCGVVFEEV | REDEAVLPVF | 
    862:
    EEKIIGKVEK | VD
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    Pfam:
    UniGene:
    SMR:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Axin-1
    Cat.:
    E9657h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Axin-1
    MSDS:
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    ELISA Kit for Human Axin-1
    Cat.:
    E9657m
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    Packing:
    96T
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    ELISA Kit for Human Axin-1
    Cat.:
    E9657r
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    MSDS:
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    Packing:
    96T
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    CLIA Kit for Human Axin-1
    Cat.:
    U9657m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Axin-1
    Cat.:
    U9657r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Axin-1
    MSDS:
    Please sign in first.
    CLIA Kit for Human Axin-1
    Cat.:
    U9657h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    Polyclonal Antibody for Human Axin-1
    Polyclonal Antibody for Human Axin-1
    Polyclonal Antibody for Human Axin-1
    Cat.:
    P9657Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Axin-1
    Cat.:
    P9657Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Axin-1
    Monoclonal Antibody for Human Axin-1
    Monoclonal Antibody for Human Axin-1
    Monoclonal Antibody for Human Axin-1
    Protein for Human Axin-1
    Protein for Human Axin-1
    Protein for Human Axin-1
    Protein for Human Axin-1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation."
      Zeng L. , Fagotto F. , Zhang T. , Hsu W. , Vasicek T.J. , Perry W.L. III , Lee J.J. , Tilghman S.M. , Gumbiner B.M. , Costantini F.
      Cell90:181-192(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16."
      Daniels R.J. , Peden J.F. , Lloyd C. , Horsley S.W. , Clark K. , Tufarelli C. , Kearney L. , Buckle V.J. , Doggett N.A. , Flint J. , Higgs D.R.
      Hum. Mol. Genet.10:339-352(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 471-862 (ISOFORM 1)
      tissue: Lymphoma.
      tissue: Renal cell carcinoma.
    5. 5.
      "Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain."
      Hsu W. , Zeng L. , Costantini F.
      J. Biol. Chem.274:3439-3445(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GSK3B AND PPP2CA;PHOSPHORYLATION;DEPHOSPHORYLATION
    6. 6.
      "AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1."
      Satoh S. , Daigo Y. , Furukawa Y. , Kato T. , Miwa N. , Nishiwaki T. , Kawasoe T. , Ishiguro H. , Fujita M. , Tokino T. , Sasaki Y. , Imaoka S. , Murata M. , Shimano T. , Yamaoka Y. , Nakamura Y.
      Nat. Genet.24:245-250(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE
    7. 7.
      "Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway."
      Mao J. , Wang J. , Liu B. , Pan W. , Farr G.H. III , Flynn C. , Yuan H. , Takada S. , Kimelman D. , Li L. , Wu D.
      Mol. Cell7:801-809(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRP5
    8. 8.
      "I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways."
      Kusano S. , Raab-Traub N.
      Mol. Cell. Biol.22:6393-6405(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MDFI AND MDFIC;FUNCTION
    9. 9.
      "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)."
      Howe P.H.
      EMBO J.22:3084-3094(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DAB2
    10. 10.
      "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms."
      Wong C.K. , Luo W. , Deng Y. , Zou H. , Ye Z. , Lin S.-C.
      J. Biol. Chem.279:39366-39373(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DIXDC1; MAP3K1 AND MAP3K4
    11. 11.
      "Increased DNA methylation at the AXIN1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly."
      Oates N.A. , van Vliet J. , Duffy D.L. , Kroes H.Y. , Martin N.G. , Boomsma D.I. , Campbell M. , Coulthard M.G. , Whitelaw E. , Chong S.
      Am. J. Hum. Genet.79:155-162(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CAUDAL DUPLICATION ANOMALY
    12. 12.
      "Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia."
      Liu W. , Rui H. , Wang J. , Lin S. , He Y. , Chen M. , Li Q. , Ye Z. , Zhang S. , Chan S.C. , Chen Y.-G. , Han J. , Lin S.-C.
      EMBO J.25:1646-1658(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SMAD6; SMAD7 AND RNF111;FUNCTION;SUBCELLULAR LOCATION
    13. 13.
      "Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death."
      Li Q. , Wang X. , Wu X. , Rui Y. , Liu W. , Wang J. , Wang X. , Liou Y.C. , Ye Z. , Lin S.C.
      Cancer Res.67:66-74(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DAXX;IDENTIFICATION AS A COMPONENT OF THE AXIN1-HIPK2-TP53 COMPLEX;SUBCELLULAR LOCATION;FUNCTION
    14. 14.
      "Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex."
      Luo W. , Peterson A. , Garcia B.A. , Coombs G. , Kofahl B. , Heinrich R. , Shabanowitz J. , Hunt D.F. , Yost H.J. , Virshup D.M.
      EMBO J.26:1511-1521(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-75; SER-77; SER-217 AND SER-469;INTERACTION WITH GSK3B AND PPP1CA;IDENTIFICATION BY MASS SPECTROMETRY
    15. 15.
      "SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability."
      Kim M.J. , Chia I.V. , Costantini F.
      FASEB J.22:3785-3794(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ADP-RIBOSYLATION;UBIQUITINATION;DOMAIN TANKYRASE-BINDING MOTIF;INTERACTION WITH TNKS AND TNKS2
    18. 18.
      "The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/beta-catenin signaling."
      Lui T.T. , Lacroix C. , Ahmed S.M. , Goldenberg S.J. , Leach C.A. , Daulat A.M. , Angers S.
      Mol. Cell. Biol.31:2053-2065(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;DEUBIQUITINATION BY USP34;SUBCELLULAR LOCATION
    19. 19.
      "RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling."
      Zhang Y. , Liu S. , Mickanin C. , Feng Y. , Charlat O. , Michaud G.A. , Schirle M. , Shi X. , Hild M. , Bauer A. , Myer V.E. , Finan P.M. , Porter J.A. , Huang S.M. , Cong F.
      Nat. Cell Biol.13:623-629(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ADP-RIBOSYLATION;UBIQUITINATION;INTERACTION WITH RNF146; TNKS AND TNKS2
    20. 20.
      "Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling."
      Callow M.G. , Tran H. , Phu L. , Lau T. , Lee J. , Sandoval W.N. , Liu P.S. , Bheddah S. , Tao J. , Lill J.R. , Hongo J.A. , Davis D. , Kirkpatrick D.S. , Polakis P. , Costa M.
      PLoS ONE6:E22595-E22595(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TNKS;UBIQUITINATION
    21. 21.
      "Structural basis of the axin-adenomatous polyposis coli interaction."
      Spink K.E. , Polakis P. , Weis W.I.
      EMBO J.19:2270-2279(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.57 ANGSTROMS) OF 74-220 IN COMPLEX WITH APC
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      "Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex."
      Dajani R. , Fraser E. , Roe S.M. , Yeo M. , Good V.M. , Thompson V. , Dale T.C. , Pearl L.H.
      EMBO J.22:494-501(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 383-400 IN COMPLEX WITH GSK3B
    23. 23.
      "Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas."
      Taniguchi K. , Roberts L.R. , Aderca I.N. , Dong X. , Qian C. , Murphy L.M. , Nagorney D.M. , Burgart L.J. , Roche P.C. , Smith D.I. , Ross J.A. , Liu W.
      Oncogene21:4863-4871(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HCC ARG-106; LEU-345; SER-425 AND SER-650;VARIANT HEPATOBLASTOMA GLN-841
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