AXIN2 ELISA Kit for Human(Homo sapiens) | EIAab.comAXIN2 ELISA Kit for Human(Homo sapiens)

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AXIN2 (Gene name),

Axin-2 (Protein name ), AXIN2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

AXIN2;

Protein name:

Axin-2;

Alternative:

Axis inhibition protein 2;Axin-like protein(Axil);Conductin;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with glycogen synthase kinase-3 beta (GSK3B) and beta-catenin. The interaction between axin and beta-catenin occurs via the armadillo repeats contained in beta-catenin (By similarity). Interacts with SMAD7 and RNF111. Interacts with ANKRD6.

Function:

Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

843

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

843:

YRYYFKKASD | EFACGAVFEE | IWEDETVLPM | YEGRILGKVE | RID

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:8313

Pfam:

PF08833

String:

Q9Y2T1

UniGene:

Hs.156527

STRING:

9606.ENSP00000302625

MIM:

114500

SMR:

Q9Y2T1

Uniprot:

Q9Y2T1

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ELISA Kit for Human Axin-2

Cat.:

E9563h

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96T

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ELISA Kit for Human Axin-2

Cat.:

E9563m

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MSDS:

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Packing:

96T

ELISA Kit for Human Axin-2

Cat.:

E9563r

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MSDS:

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Packing:

96T

CLIA Kit for Human Axin-2

Cat.:

U9563h

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Manual:

Looking for manual.

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Packing:

96T

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CLIA Kit for Human Axin-2

Cat.:

U9563m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Axin-2

Cat.:

U9563r

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Axin-2

Cat.:

P9563Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Axin-2

Cat.:

P9563Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Axin-2

Monoclonal Antibody for Human Axin-2

Protein for Human Axin-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24."
Mai M. , Qian C. , Yokomizo A. , Smith D.I. , Liu W.
Genomics55:341-344(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Properties of mouse Axin2 and human AXIN2: chromosomal location, expression pattern, interaction with Axin and effects on embryonic axis formation."
Zhang T. , Fagotto F. , Hsu W. , Zeng L. , Gilbert D. , Copeland N.G. , Jenkins N.A. , Warburton D. , Costantini F.
Submitted (1999-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
tissue: Lymphoblast.
3.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
5.

"Identification of 3' UTR of Axin2."
Takahashi M. , Furukawa Y.
Submitted (2000-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 697-843
6.

"Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling."
Liu W. , Dong X. , Mai M. , Seelan R.S. , Taniguchi K. , Krishnadath K.K. , Halling K.C. , Cunningham J.M. , Qian C. , Christensen E. , Roches P.C. , Smith D.I. , Thibodeau S.N.
Nat. Genet.26:146-147(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN COLORECTAL CANCER
7.

"Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer."
Lammi L. , Arte S. , Somer M. , Jarvinen H. , Lahermo P. , Thesleff I. , Pirinen S. , Nieminen P.
Am. J. Hum. Genet.74:1043-1050(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN ODCRCS
8.

"Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia."
Liu W. , Rui H. , Wang J. , Lin S. , He Y. , Chen M. , Li Q. , Ye Z. , Zhang S. , Chan S.C. , Chen Y.-G. , Han J. , Lin S.-C.
EMBO J.25:1646-1658(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SMAD7 AND RNF111
9.

"Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling."
Huang S.M. , Mishina Y.M. , Liu S. , Cheung A. , Stegmeier F. , Michaud G.A. , Charlat O. , Wiellette E. , Zhang Y. , Wiessner S. , Hild M. , Shi X. , Wilson C.J. , Mickanin C. , Myer V. , Fazal A. , Tomlinson R. , Serluca F. , more...
Nature461:614-620(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ADP-RIBOSYLATION;UBIQUITINATION;INTERACTION WITH TNKS AND TNKS2
10.

"The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/beta-catenin signaling."
Lui T.T. , Lacroix C. , Ahmed S.M. , Goldenberg S.J. , Leach C.A. , Daulat A.M. , Angers S.
Mol. Cell. Biol.31:2053-2065(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;DEUBIQUITINATION BY USP34
11.

"RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling."
Zhang Y. , Liu S. , Mickanin C. , Feng Y. , Charlat O. , Michaud G.A. , Schirle M. , Shi X. , Hild M. , Bauer A. , Myer V.E. , Finan P.M. , Porter J.A. , Huang S.M. , Cong F.
Nat. Cell Biol.13:623-629(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ADP-RIBOSYLATION;UBIQUITINATION;INTERACTION WITH RNF146; TNKS AND TNKS2
12.

"Single nucleotide polymorphism of the AXIN2 gene is preferentially associated with human lung cancer risk in a Japanese population."
Kanzaki H. , Ouchida M. , Hanafusa H. , Yano M. , Suzuki H. , Aoe M. , Imai K. , Shimizu N. , Nakachi K. , Shimizu K.
Int. J. Mol. Med.18:279-284(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PRO-50

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