Protein name:
Beta-secretase 2 ;
Alternative:
Memapsin-1 ;Beta-site amyloid precursor protein cleaving enzyme 2 (Beta-site APP cleaving enzyme 2) ;Theta-secretase ;Membrane-associated aspartic protease 1 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Monomer. Interacts ith RTN3 and RTN4.
Function:
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Golgi apparatus
Endoplasmic reticulum
Endosome
Cell surface
Protein Attributes:
50:
MGALLRALLL | PLLAQWLLRA | VPVLAPAPFT | LPLQVAGAAN | HRASTVPGLG |
100:
TPELPRADGL | ALALEPARAT | ANFLAMVDNL | QGDSGRGYYL | EMLIGTPPQK |
150:
VRILVDTGSS | NFAVAGAPHS | YIDTYFDSES | SSTYHSKGFE | VTVKYTQGSW |
200:
TGFVGEDLVT | IPKGFNSSFL | VNIATIFESE | NFFLPGIKWN | GILGLAYAAL |
250:
AKPSSSLETF | FDSLVAQAKI | PDIFSMQMCG | AGLPVAGSGT | NGGSLVLGGI |
300:
EPSLYKGDIW | YTPIKEEWYY | QIEILKLEIG | GQSLNLDCRE | YNADKAIVDS |
350:
GTTLLRLPQK | VFDAVVEAVA | RTSLIPEFSD | GFWTGAQLAC | WTNSETPWAY |
400:
FPKISIYLRD | ENASRSFRIT | ILPQLYIQPM | MGAGFNYECY | RFGISSSTNA |
450:
LVIGATVMEG | FYVVFDRAQR | RVGFAVSPCA | EIAGTTVSEI | SGPFSTEDIA |
500:
SNCVPAQALN | EPILWIVSYA | LMSVCGAILL | VLILLLLFPL | HCRHAPRDPE |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
ELISA Kit for Rat Beta-secretase 2
ELISA Kit for Rat Beta-secretase 2
ELISA Kit for Rat Beta-secretase 2
CLIA Kit for Rat Beta-secretase 2
CLIA Kit for Rat Beta-secretase 2
CLIA Kit for Rat Beta-secretase 2
Polyclonal Antibody for Rat Beta-secretase 2
Polyclonal Antibody for Rat Beta-secretase 2
Polyclonal Antibody for Rat Beta-secretase 2
Monoclonal Antibody for Rat Beta-secretase 2
Monoclonal Antibody for Rat Beta-secretase 2
Monoclonal Antibody for Rat Beta-secretase 2
Protein for Rat Beta-secretase 2
Protein for Rat Beta-secretase 2
Protein for Rat Beta-secretase 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Prostate .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION
strain :
Sprague-Dawley .