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Index > Protein center > BSG(Gene name) > Human
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  • BSG (Gene name),
  • Basigin (Protein name ),  BASI_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    BSG(UNQ6505/PRO21383);
    Protein name:
    Basigin;
    Alternative:
    Collagenase stimulatory factor;5F7;Leukocyte activation antigen M6;Extracellular matrix metalloproteinase inducer(EMMPRIN);Tumor cell-derived collagenase stimulatory factor(TCSF);OK blood group antigen;
    CD:
    CD147;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms homooligomers in a cis-dependent manner on the plasma membrane. Forms a complex with MMP1 at the tumor cell surface. Interacts with SLC16A1 and SLC1A3; probably a BSG dimer is associated with a monocarboxylate transporter dimer. Interacts with ATP1B2, MAG and L1CAM (By similarity). Interacts with AJAP1.
    Function:
    Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). May target monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to plasma membranes of retinal pigment epithelium and neural retina. Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein Melanosome Colocalizes with SLC16A1 and SLC16A8 (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
    Protein Attributes:
    Sequence length:
    385
    Sequence:
    50:
    MAAALFVLLG | FALLGTHGAS | GAAGFVQAPL | SQQRWVGGSV | ELHCEAVGSP | 
    100:
    VPEIQWWFEG | QGPNDTCSQL | WDGARLDRVH | IHATYHQHAA | STISIDTLVE | 
    150:
    EDTGTYECRA | SNDPDRNHLT | RAPRVKWVRA | QAVVLVLEPG | TVFTTVEDLG | 
    200:
    SKILLTCSLN | DSATEVTGHR | WLKGGVVLKE | DALPGQKTEF | KVDSDDQWGE | 
    250:
    YSCVFLPEPM | GTANIQLHGP | PRVKAVKSSE | HINEGETAML | VCKSESVPPV | 
    300:
    TDWAWYKITD | SEDKALMNGS | ESRFFVSSSQ | GRSELHIENL | NMEADPGQYR | 
    350:
    CNGTSSKGSD | QAIITLRVRS | HLAALWPFLG | IVAEVLVLVT | IIFIYEKRRK | 
    385:
    PEDVLDDDDA | GSAPLKSSGQ | HQNDKGKNVR | QRNSS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    Pfam:
    UniGene:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Basigin
    Cat.:
    E1850h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Basigin
    Cat.:
    E1850r
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Basigin
    Cat.:
    E1850m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Basigin
    Cat.:
    E1850c
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Basigin
    MSDS:
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    ELISA Kit for Human Basigin
    Cat.:
    E1850b
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Basigin
    Cat.:
    U1850r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Basigin
    Cat.:
    U1850b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Basigin
    Cat.:
    U1850c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Basigin
    Cat.:
    U1850m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Basigin
    MSDS:
    Please sign in first.
    CLIA Kit for Human Basigin
    Cat.:
    U1850h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    Polyclonal Antibody for Human Basigin
    Polyclonal Antibody for Human Basigin
    Polyclonal Antibody for Human Basigin
    Cat.:
    P1850Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Basigin
    Cat.:
    P1850Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Basigin
    Cat.:
    P1850Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Basigin
    Monoclonal Antibody for Human Basigin
    Monoclonal Antibody for Human Basigin
    Monoclonal Antibody for Human Basigin
    Monoclonal Antibody for Human Basigin
    Monoclonal Antibody for Human Basigin
    Monoclonal Antibody for Human Basigin
    Protein for Human Basigin
    Protein for Human Basigin
    Protein for Human Basigin
    Protein for Human Basigin
    Protein for Human Basigin
    Protein for Human Basigin

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    Recovery
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    Linearity
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    References
    1. 1.
      "Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule."
      Kasinrerk W. , Fiebiger E. , Stefanova I. , Baumruker T. , Knapp W. , Stockinger H.
      J. Immunol.149:847-854(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    2. 2.
      "The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen."
      Miyauchi T. , Masuzawa Y. , Muramatsu T.
      J. Biochem.110:770-774(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2)
    3. 3.
      "The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily."
      Biswas C. , Zhang Y. , Decastro R. , Guo H. , Nakamura T. , Kataoka H. , Nabeshima K.
      Cancer Res.55:434-439(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    4. 4.
      Wakasugi H. , Scamps C. , Yang G. , Vancong N. , Bernheim A. , Tursz T. , Harada N.
      Submitted (1996-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2)
    5. 5.
      Decastro R. , Zhang Y. , Kataoka H. , Coon J. , Biswas C.
      Submitted (1996-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2)
    6. 6.
      "Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases."
      Guo H. , Majmudar G. , Jensen T.C. , Biswas C. , Toole B.P. , Gordon M.K.
      Gene220:99-108(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2)
    7. 7.
      "Regulation of EMMPRIN/CD147 expression and its function of controlling matrix metalloproteinases production and cell-surface localization in co-culture of human uterine cervical carcinoma SKG-II cells and human uterine cervical fibroblasts."
      Sato T. , Takita M. , Noguchi Y. , Hirata M. , Sakai T. , Ito A.
      Submitted (2001-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2)
    8. 8.
      Kim D. , Kanai Y. , Choi H. , Shin H. , Kim J. , Teraoka H. , Shigeta Y. , Chairoungdua A. , Babu E. , Anzai N. , Iribe Y. , Endou H.
      Submitted (2002-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2)
    9. 9.
      "Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily."
      Ochrietor J.D. , Moroz T.P. , van Ekeris L. , Clamp M.F. , Jefferson S.C. , deCarvalho A.C. , Fadool J.M. , Wistow G. , Muramatsu T. , Linser P.J.
      Invest. Ophthalmol. Vis. Sci.44:4086-4096(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1)
      tissue: Retina.
    10. 10.
      "Characterization of basigin isoforms and the inhibitory function of basigin-3 in human hepatocellular carcinoma proliferation and invasion."
      Liao C.G. , Kong L.M. , Song F. , Xing J.L. , Wang L.X. , Sun Z.J. , Tang H. , Yao H. , Zhang Y. , Wang L. , Wang Y. , Yang X.M. , Li Y. , Chen Z.N.
      Mol. Cell. Biol.31:2591-2604(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4);SUBUNIT;SUBCELLULAR LOCATION;ALTERNATIVE PROMOTER USAGE
    11. 11.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    12. 12.
      SeattleSNPs variation discovery resource
      Submitted (2005-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    13. 13.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    15. 15.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Eye.
    16. 16.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 22-36 (ISOFORM 1)
    17. 17.
      "Partial sequencing and characterization of the tumor cell-derived collagenase stimulatory factor."
      Nabeshima K. , Lane W.S. , Biswas C.
      Arch. Biochem. Biophys.285:90-96(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;CHARACTERIZATION
    18. 18.
      "Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion."
      Muramatsu T. , Miyauchi T.
      Histol. Histopathol.18:981-987(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    19. 19.
      "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H. , Li X.-J. , Martin D.B. , Aebersold R.
      Nat. Biotechnol.21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-160 AND ASN-268
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPIL2;SUBCELLULAR LOCATION;MUTAGENESIS OF PRO-327
    21. 21.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    22. 22.
      "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
      Chi A. , Valencia J.C. , Hu Z.-Z. , Watabe H. , Yamaguchi H. , Mangini N.J. , Huang H. , Canfield V.A. , Cheng K.C. , Yang F. , Abe R. , Yamagishi S. , Shabanowitz J. , Hearing V.J. , Wu C. , Appella E. , Hunt D.F.
      J. Proteome Res.5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
      tissue: Melanoma.
    23. 23.
      "The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity."
      Manoharan C. , Wilson M.C. , Sessions R.B. , Halestrap A.P.
      Mol. Membr. Biol.23:486-498(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH SLC16A1
    24. 24.
      "junction protein shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147."
      Schreiner A. , Ruonala M. , Jakob V. , Suthaus J. , Boles E. , Wouters F. , Starzinski-Powitz A.
      Mol. Biol. Cell18:1272-1281(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AJAP1
    25. 25.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    26. 26.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-160 AND ASN-268
      tissue: Liver.
    27. 27.
      "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
      Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-160 AND ASN-268
      tissue: Leukemic T-cell.
    28. 28.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    29. 29.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    30. 30.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    31. 31.
      "Crystal structure of HAb18G/CD147: implications for immunoglobulin superfamily homophilic adhesion."
      Yu X.-L. , Hu T. , Du J.-M. , Ding J.-P. , Yang X.-M. , Zhang J. , Yang B. , Shen X. , Zhang Z. , Zhong W.-D. , Wen N. , Jiang H. , Zhu P. , Chen Z.-N.
      J. Biol. Chem.283:18056-18065(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 140-321;SUBUNIT;DISULFIDE BONDS
    32. 32.
      "Structure of the EMMPRIN N-terminal domain 1: dimerization via beta-strand swapping."
      Luo J. , Teplyakov A. , Obmolova G. , Malia T. , Wu S.-J. , Beil E. , Baker A. , Swencki-Underwood B. , Zhao Y. , Sprenkle J. , Dixon K. , Sweet R. , Gilliland G.L.
      Proteins77:1009-1014(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 13-219;IDENTIFICATION BY MASS SPECTROMETRY;SUBUNIT;DISULFIDE BONDS
    33. 33.
      "The Ok(a) blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX-47 antigen, basigin and neurothelin, an immunoglobulin superfamily molecule that is widely expressed in human cells and tissues."
      Spring F.A. , Holmes C.H. , Simpson K.L. , Mawby W.J. , Mattes M.J. , Okubo Y. , Parsons S.F.
      Eur. J. Immunol.27:891-897(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LYS-208
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