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Index > Protein center > BBC3(Gene name) > Human
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  • BBC3 (Gene name),
  • Bcl-2-binding component 3 (Protein name ),  BBC3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    BBC3(PUMA);
    Protein name:
    Bcl-2-binding component 3;
    Alternative:
    JFY-1;p53 up-regulated modulator of apoptosis;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with MCL1 and BCL2A1 (By similarity). Interacts with BCL2 and BCL2L1/BCL-XL.
    Function:
    Essential mediator of p53-dependent and p53-independent apoptosis.
    Subcellular Location:
    Mitochondrion Localized to the mitochondria in order to induce cytochrome c release.
    Protein Attributes:
    Sequence length:
    193
    Sequence:
    50:
    MARARQEGSS | PEPVEGLARD | GPRPFPLGRL | VPSAVSCGLC | EPGLAAAPAA | 
    100:
    PTLLPAAYLC | APTAPPAVTA | ALGGSRWPGG | PRSRPRGPRP | DGPQPSLSLA | 
    150:
    EQHLESPVPS | APGALAGGPT | QAAPGVRGEE | EQWAREIGAQ | LRRMADDLNA | 
    193:
    QYERRRQEEQ | QRHRPSPWRV | LYNLIMGLLP | LPRGHRAPEM | EPN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    UniGene:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Bcl-2-binding component 3
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    E1909h
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    Packing:
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    ELISA Kit for Human Bcl-2-binding component 3
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    E1909r
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    ELISA Kit for Human Bcl-2-binding component 3
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    E1909m
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    ELISA Kit for Human Bcl-2-binding component 3
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    E1909h
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    CLIA Kit for Human Bcl-2-binding component 3
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    CLIA Kit for Human Bcl-2-binding component 3
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    U1909r
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    96T
    CLIA Kit for Human Bcl-2-binding component 3
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    U1909h
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    CLIA Kit for Human Bcl-2-binding component 3
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    U1909h
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    Packing:
    96T
    Polyclonal Antibody for Human Bcl-2-binding component 3
    Cat.:
    P1909Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Bcl-2-binding component 3
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    P1909Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Bcl-2-binding component 3
    Cat.:
    P1909Rb-r
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    40ug/0.2ml
    Polyclonal Antibody for Human Bcl-2-binding component 3
    Cat.:
    P1909Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Bcl-2-binding component 3
    Monoclonal Antibody for Human Bcl-2-binding component 3
    Monoclonal Antibody for Human Bcl-2-binding component 3
    Monoclonal Antibody for Human Bcl-2-binding component 3
    Protein for Human Bcl-2-binding component 3
    Protein for Human Bcl-2-binding component 3
    Protein for Human Bcl-2-binding component 3
    Protein for Human Bcl-2-binding component 3

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "PUMA induces the rapid apoptosis of colorectal cancer cells."
      Yu J. , Zhang L. , Hwang P.M. , Kinzler K.W. , Vogelstein B.
      Mol. Cell7:673-682(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH BCL2 AND BCL2L1;TISSUE SPECIFICITY
    2. 2.
      "PUMA, a novel proapoptotic gene, is induced by p53."
      Nakano K. , Wousden K.H.
      Mol. Cell7:683-694(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4);INDUCTION;SUBCELLULAR LOCATION
    3. 3.
      "Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals."
      Han J.-W. , Flemington C. , Houghton A.B. , Gu Z. , Zambetti G.P. , Lutz R.J. , Zhu L. , Chittenden T.
      Proc. Natl. Acad. Sci. U.S.A.98:11318-11323(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INDUCTION;SUBCELLULAR LOCATION
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Testis.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    7. 7.
      "CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress."
      Ghosh A.P. , Klocke B.J. , Ballestas M.E. , Roth K.A.
      PLoS ONE7:E39586-E39586(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    8. 8.
      "PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis."
      Follis A.V. , Chipuk J.E. , Fisher J.C. , Yun M.K. , Grace C.R. , Nourse A. , Baran K. , Ou L. , Min L. , White S.W. , Green D.R. , Kriwacki R.W.
      Nat. Chem. Biol.9:163-168(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 130-154 IN COMPLEX WITH BCL2L1;STRUCTURE BY NMR OF 130-154 IN COMPLEX WITH BCL2L1;FUNCTION;DOMAIN;MUTAGENESIS OF TRP-133;INTERACTION WITH BCL2L1
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