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Index > Protein center > BCAM(Gene name) > Human
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  • BCAM (Gene name),
  • Basal cell adhesion molecule (Protein name ),  BCAM_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    BCAM(LU;MSK19);
    Protein name:
    Basal cell adhesion molecule;
    Alternative:
    B-CAM cell surface glycoprotein;Auberger B antigen;Lutheran antigen;F8/G253 antigen;Lutheran blood group glycoprotein;
    CD:
    CD239;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Laminin alpha-5 receptor. May mediate intracellular signaling.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    628
    Sequence:
    50:
    MEPPDAPAQA | RGAPRLLLLA | VLLAAHPDAQ | AEVRLSVPPL | VEVMRGKSVI | 
    100:
    LDCTPTGTHD | HYMLEWFLTD | RSGARPRLAS | AEMQGSELQV | TMHDTRGRSP | 
    150:
    PYQLDSQGRL | VLAEAQVGDE | RDYVCVVRAG | AAGTAEATAR | LNVFAKPEAT | 
    200:
    EVSPNKGTLS | VMEDSAQEIA | TCNSRNGNPA | PKITWYRNGQ | RLEVPVEMNP | 
    250:
    EGYMTSRTVR | EASGLLSLTS | TLYLRLRKDD | RDASFHCAAH | YSLPEGRHGR | 
    300:
    LDSPTFHLTL | HYPTEHVQFW | VGSPSTPAGW | VREGDTVQLL | CRGDGSPSPE | 
    350:
    YTLFRLQDEQ | EEVLNVNLEG | NLTLEGVTRG | QSGTYGCRVE | DYDAADDVQL | 
    400:
    SKTLELRVAY | LDPLELSEGK | VLSLPLNSSA | VVNCSVHGLP | TPALRWTKDS | 
    450:
    TPLGDGPMLS | LSSITFDSNG | TYVCEASLPT | VPVLSRTQNF | TLLVQGSPEL | 
    500:
    KTAEIEPKAD | GSWREGDEVT | LICSARGHPD | PKLSWSQLGG | SPAEPIPGRQ | 
    550:
    GWVSSSLTLK | VTSALSRDGI | SCEASNPHGN | KRHVFHFGTV | SPQTSQAGVA | 
    600:
    VMAVAVSVGL | LLLVVAVFYC | VRRKGGPCCR | QRREKGAPPP | GEPGLSHSGS | 
    628:
    EQPEQTGLLM | GGASGGARGG | SGGFGDEC
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    SMR:
    KEGG:
    MIM:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Basal cell adhesion molecule
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    ELISA Kit for Human Basal cell adhesion molecule
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    ELISA Kit for Human Basal cell adhesion molecule
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    CLIA Kit for Human Basal cell adhesion molecule
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    Polyclonal Antibody for Human Basal cell adhesion molecule
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    P9357Rb-h
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    Polyclonal Antibody for Human Basal cell adhesion molecule
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    Packing:
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    Polyclonal Antibody for Human Basal cell adhesion molecule
    Polyclonal Antibody for Human Basal cell adhesion molecule
    Monoclonal Antibody for Human Basal cell adhesion molecule
    Monoclonal Antibody for Human Basal cell adhesion molecule
    Monoclonal Antibody for Human Basal cell adhesion molecule
    Monoclonal Antibody for Human Basal cell adhesion molecule
    Protein for Human Basal cell adhesion molecule
    Protein for Human Basal cell adhesion molecule
    Protein for Human Basal cell adhesion molecule
    Protein for Human Basal cell adhesion molecule

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    References
    1. 1.
      "The Lutheran blood group glycoprotein, another member of the immunoglobulin superfamily, is widely expressed in human tissues and is developmentally regulated in human liver."
      Parsons S.F. , Mallinson G. , Holmes C.H. , Houlihan J.M. , Simpson K.L. , Mawby W.J. , Spurr N.K. , Warne D. , Barclay A.N. , Anstee D.J.
      Proc. Natl. Acad. Sci. U.S.A.92:5496-5500(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 32-67 AND 182-203;VARIANT ALA-539
      tissue: Placenta.
    2. 2.
      SeattleSNPs variation discovery resource
      Submitted (2004-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS HIS-77; ILE-196; LYS-204; HIS-282; ILE-381; GLN-451 AND LEU-581
    3. 3.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    6. 6.
      "Molecular cloning of the B-CAM cell surface glycoprotein of epithelial cancers: a novel member of the immunoglobulin superfamily."
      Campbell I.G. , Foulkes W.D. , Senger G. , Trowsdale J. , Garin-Chesa P. , Rettig W.J.
      Cancer Res.54:5761-5765(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-588;VARIANT ALA-539
    7. 7.
      "Molecular basis of Lub(-) individual among Chinese blood donors in Shanghai area."
      Wang C. , Li Q. , Guo Z. , Yang Y. , Zhu Z.
      Submitted (2007-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 492-539;VARIANT ALA-539
    8. 8.
      "Use of domain-deletion mutants to locate Lutheran blood group antigens to each of the five immunoglobulin superfamily domains of the Lutheran glycoprotein: elucidation of the molecular basis of the Lu(a)/Lu(b) and the Au(a)/Au(b) polymorphisms."
      Parsons S.F. , Mallinson G. , Daniels G.L. , Green C.A. , Smythe J.S. , Anstee D.J.
      Blood89:4219-4225(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LU(A)/LU(B) POLYMORPHISM
    9. 9.
      "Organization of the human LU gene and molecular basis of the Lu(a)/Lu(b) blood group polymorphism."
      El Nemer W. , Rahuel C. , Colin Y. , Gane P. , Cartron J.P. , Le Van Kim C.
      Blood89:4608-4616(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LU(A)/LU(B) POLYMORPHISM
    10. 10.
      "Basal cell adhesion molecule/lutheran protein. The receptor critical for sickle cell adhesion to laminin."
      Udani M. , Zen Q. , Cottman M. , Leonard N. , Jefferson S. , Daymont C. , Truskey G. , Telen M.J.
      J. Clin. Invest.101:2550-2558(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    11. 11.
      "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H. , Li X.-J. , Martin D.B. , Aebersold R.
      Nat. Biotechnol.21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-439
    12. 12.
      "Protein kinase A-dependent phosphorylation of Lutheran/basal cell adhesion molecule glycoprotein regulates cell adhesion to laminin alpha5."
      Gauthier E. , Rahuel C. , Wautier M.P. , El Nemer W. , Gane P. , Wautier J.L. , Cartron J.P. , Colin Y. , Le Van Kim C.
      J. Biol. Chem.280:30055-30062(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-596; SER-598 AND SER-621;MUTAGENESIS OF SER-621
    13. 13.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-439
      tissue: Plasma.
    14. 14.
      "Different inactivating mutations in the LU genes of three individuals with the Lutheran-null phenotype."
      Karamatic Crew V. , Mallinson G. , Green C. , Poole J. , Uchikawa M. , Tani Y. , Geisen C. , Oldenburg J. , Daniels G.
      Transfusion47:492-498(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN THE LUTHERAN NULL PHENOTYPE
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 16.
      "The Laminin 511/521-binding site on the Lutheran blood group glycoprotein is located at the flexible junction of Ig domains 2 and 3."
      Mankelow T.J. , Burton N. , Stefansdottir F.O. , Spring F.A. , Parsons S.F. , Pedersen J.S. , Oliveira C.L. , Lammie D. , Wess T. , Mohandas N. , Chasis J.A. , Brady R.L. , Anstee D.J.
      Blood110:3398-3406(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 32-262;LAMININ-ALPHA5 BINDING REGION;DISULFIDE BONDS
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