Protein name:
Apoptosis regulator Bcl-2 ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity. Also interacts with APAF1, BBC3, BCL2L1, BNIPL, EI24, MRPL41, RAF-1 and TP53BP2. Binding to FKBP8 seems to target BCL2 to the mitochondria and probably interferes with the binding of BCL2 to its targets. Interacts with BAG1 in an ATP-dependent manner.
Function:
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Subcellular Location:
Mitochondrion outer membrane
Single-pass membrane protein
Nucleus membrane
Single-pass membrane protein
Endoplasmic reticulum membrane
Single-pass membrane protein
Protein Attributes:
50:
MAQAGRTGYD | NREIVMKYIH | YKLSQRGYEW | DAGDADAAPL | GAAPTPGIFS |
100:
FQPESNPMPA | VHREMAARTS | PLRPLVATAG | PALSPVPPCV | HLTLRRAGDD |
150:
FSRRYRRDFA | EMSSQLHLTP | FTARGRFATV | VEELFRDGVN | WGRIVAFFEF |
200:
GGVMCVESVN | REMSPLVDNI | ALWMTEYLNR | HLHTWIQDNG | GWDAFVELYG |
236:
PSMRPLFDFS | WLSLKTLLSL | ALVGACITLG | AYLGHK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Bovine
Human
Mouse
Chicken
Dog
ELISA Kit for Mouse Apoptosis regulator Bcl-2
ELISA Kit for Mouse Apoptosis regulator Bcl-2
ELISA Kit for Mouse Apoptosis regulator Bcl-2
ELISA Kit for Mouse Apoptosis regulator Bcl-2
ELISA Kit for Mouse Apoptosis regulator Bcl-2
ELISA Kit for Mouse Apoptosis regulator Bcl-2
CLIA Kit for Mouse Apoptosis regulator Bcl-2
CLIA Kit for Mouse Apoptosis regulator Bcl-2
CLIA Kit for Mouse Apoptosis regulator Bcl-2
CLIA Kit for Mouse Apoptosis regulator Bcl-2
CLIA Kit for Mouse Apoptosis regulator Bcl-2
CLIA Kit for Mouse Apoptosis regulator Bcl-2
Polyclonal Antibody for Mouse Apoptosis regulator Bcl-2
Polyclonal Antibody for Mouse Apoptosis regulator Bcl-2
Polyclonal Antibody for Mouse Apoptosis regulator Bcl-2
Polyclonal Antibody for Mouse Apoptosis regulator Bcl-2
Polyclonal Antibody for Mouse Apoptosis regulator Bcl-2
Polyclonal Antibody for Mouse Apoptosis regulator Bcl-2
Monoclonal Antibody for Mouse Apoptosis regulator Bcl-2
Monoclonal Antibody for Mouse Apoptosis regulator Bcl-2
Monoclonal Antibody for Mouse Apoptosis regulator Bcl-2
Monoclonal Antibody for Mouse Apoptosis regulator Bcl-2
Monoclonal Antibody for Mouse Apoptosis regulator Bcl-2
Monoclonal Antibody for Mouse Apoptosis regulator Bcl-2
Protein for Mouse Apoptosis regulator Bcl-2
Protein for Mouse Apoptosis regulator Bcl-2
Protein for Mouse Apoptosis regulator Bcl-2
Protein for Mouse Apoptosis regulator Bcl-2
Protein for Mouse Apoptosis regulator Bcl-2
Protein for Mouse Apoptosis regulator Bcl-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS ALPHA AND BETA)
strain :
BALB/c .
tissue :
Liver .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SEQUENCE REVISION TO 221-222
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"Lineage-specific biology revealed by a finished genome assembly of the mouse."
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PLoS Biol.7:E1000112-E1000112(2009)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Olfactory epithelium .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-70 BY PKC;MUTAGENESIS OF SER-70
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DEPHOSPHORYLATION BY PP2A
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH EI24