Protein name:
Apoptosis regulator Bcl-2 ;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity. Also interacts with APAF1, BBC3, BCL2L1, BNIPL, EI24, FKBP8, MRPL41, RAF-1, TP53BP2. Interacts with BAG1 in an ATP-dependent manner.
Function:
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Subcellular Location:
Mitochondrion outer membrane
Single-pass membrane protein
Nucleus membrane
Single-pass membrane protein
Endoplasmic reticulum membrane
Single-pass membrane protein
Protein Attributes:
50:
MAQAGRTGYD | NREIVMKYIH | YKLSQRGYEW | DTGDEDSAPL | RAAPTPGIFS |
100:
FQPESNRTPA | VHRDTAARTS | PLRPLVANAG | PALSPVPPVV | HLTLRRAGDD |
150:
FSRRYRRDFA | EMSSQLHLTP | FTARGRFATV | VEELFRDGVN | WGRIVAFFEF |
200:
GGVMCVESVN | REMSPLVDNI | ALWMTEYLNR | HLHTWIQDNG | GWDAFVELYG |
236:
PSMRPLFDFS | WLSLKTLLSL | ALVGACITLG | AYLGHK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Bovine
Human
Mouse
Chicken
Dog
ELISA Kit for Rat Apoptosis regulator Bcl-2
ELISA Kit for Rat Apoptosis regulator Bcl-2
ELISA Kit for Rat Apoptosis regulator Bcl-2
ELISA Kit for Rat Apoptosis regulator Bcl-2
ELISA Kit for Rat Apoptosis regulator Bcl-2
ELISA Kit for Rat Apoptosis regulator Bcl-2
CLIA Kit for Rat Apoptosis regulator Bcl-2
CLIA Kit for Rat Apoptosis regulator Bcl-2
CLIA Kit for Rat Apoptosis regulator Bcl-2
CLIA Kit for Rat Apoptosis regulator Bcl-2
CLIA Kit for Rat Apoptosis regulator Bcl-2
CLIA Kit for Rat Apoptosis regulator Bcl-2
Polyclonal Antibody for Rat Apoptosis regulator Bcl-2
Polyclonal Antibody for Rat Apoptosis regulator Bcl-2
Polyclonal Antibody for Rat Apoptosis regulator Bcl-2
Polyclonal Antibody for Rat Apoptosis regulator Bcl-2
Polyclonal Antibody for Rat Apoptosis regulator Bcl-2
Polyclonal Antibody for Rat Apoptosis regulator Bcl-2
Monoclonal Antibody for Rat Apoptosis regulator Bcl-2
Monoclonal Antibody for Rat Apoptosis regulator Bcl-2
Monoclonal Antibody for Rat Apoptosis regulator Bcl-2
Monoclonal Antibody for Rat Apoptosis regulator Bcl-2
Monoclonal Antibody for Rat Apoptosis regulator Bcl-2
Monoclonal Antibody for Rat Apoptosis regulator Bcl-2
Protein for Rat Apoptosis regulator Bcl-2
Protein for Rat Apoptosis regulator Bcl-2
Protein for Rat Apoptosis regulator Bcl-2
Protein for Rat Apoptosis regulator Bcl-2
Protein for Rat Apoptosis regulator Bcl-2
Protein for Rat Apoptosis regulator Bcl-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Y Atef, H M.Ei-Fayoumi, M F.Mahmoud, et al.
[2].
Wei Zhang, Hongqi Feng, Yanhui Gao, Liyan Sun, Jing Wang, Yuanyuan Li, Cheng Wang, Lijun Zhao, Xinxin Hu, Huixin Sun, Yudan Wei, Dianjun Sun
[3].
Tare K. M, Shohda A. E, Aliaa Nabil E, et al.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Sprague-Dawley .
tissue :
Ovary .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 19-172
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PPIF