Gene name:
Gm6484 (Angptl8;Rifl) ;
Protein name:
Betatrophin ;
Alternative:
Lipasin ;Angiopoietin-like protein 8 ;Refeeding-induced fat and liver protein ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with ANGPTL3.
Function:
Hormone that specifically promotes pancreatic beta cell proliferation and beta cell mass expansion, thereby improving glucose tolerance. Promotes pancreatic beta cell proliferation without insulin resistance. Also acts as a blood lipid regulator by regulating serum triglyceride levels; possibly by promoting ANGPTL3 cleavage.
Subcellular Location:
Secreted
Protein Attributes:
50:
MAVLALCLLW | TLASAVRPAP | VAPLGGPEPA | QYEELTLLFH | GALQLGQALN |
100:
GVYRATEARL | TEAGHSLGLY | DRALEFLGTE | VRQGQDATQE | LRTSLSEIQV |
150:
EEDALHLRAE | ATARSLGEVA | RAQQALRDTV | RRLQVQLRGA | WLGQAHQEFE |
198:
TLKARADKQS | HLLWALTGHV | QRQQREMAEQ | QQWLRQIQQR | LHTAALPA
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
ELISA Kit for Mouse Betatrophin
CLIA Kit for Mouse Betatrophin
Polyclonal Antibody for Mouse Betatrophin
Monoclonal Antibody for Mouse Betatrophin
Protein for Mouse Betatrophin
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Citations
[1].
Puhan L, Xi C, Zeqing Z, et al.
References
1.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
Goodstadt L.
,
Hillier L.W.
,
Zody M.C.
,
Goldstein S.
,
She X.
,
Bult C.J.
,
Agarwala R.
,
Cherry J.L.
,
DiCuccio M.
,
Hlavina W.
,
Kapustin Y.
,
Meric P.
,
Maglott D.
,
Birtle Z.
,
Marques A.C.
,
Graves T.
,
Zhou S.
,
Teague B.
,
Potamousis K.
,
Churas C.
,
Place M.
,
Herschleb J.
,
Runnheim R.
,
Forrest D.
,
Amos-Landgraf J.
,
Schwartz D.C.
,
Cheng Z.
,
Lindblad-Toh K.
,
Eichler E.E.
,
Ponting C.P.
more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 18-181
strain :
FVB/N .
tissue :
Liver .
3.
"A mouse knockout library for secreted and transmembrane proteins."
Tang T.
,
Li L.
,
Tang J.
,
Li Y.
,
Lin W.Y.
,
Martin F.
,
Grant D.
,
Solloway M.
,
Parker L.
,
Ye W.
,
Forrest W.
,
Ghilardi N.
,
Oravecz T.
,
Platt K.A.
,
Rice D.S.
,
Hansen G.M.
,
Abuin A.
,
Eberhart D.E.
,
Godowski P.
,
Holt K.H.
,
Peterson A.
,
Zambrowicz B.P.
,
de Sauvage F.J.
more...
Nat. Biotechnol.28:749-755(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY;INDUCTION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INDUCTION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;TISSUE SPECIFICITY
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : EXPRESSION IN HUMAN PANCREATIC BETA-CELLS
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ROLE IN PANCREATIC BETA-CELLS PROLIFERATION
12.
"ANGPTL8/betatrophin does not control pancreatic beta cell expansion."
Gusarova V.
,
Alexa C.A.
,
Na A.
,
Stevis P.E.
,
Xin Y.
,
Bonner-Weir S.
,
Cohen J.C.
,
Hobbs H.H.
,
Murphy A.J.
,
Yancopoulos G.D.
,
Gromada J.
Cell159:691-696(2014)
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE