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Index > Protein center > ABO(Gene name) > Human
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  • ABO (Gene name),
  • Histo-blood group ABO system transferase (Protein name ),  BGAT_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ABO;
    Protein name:
    Histo-blood group ABO system transferase;
    Alternative:
    Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase;Fucosylglycoprotein 3-alpha-galactosyltransferase;2.4.1.37;Glycoprotein-fucosylgalactoside alpha-galactosyltransferase);2.4.1.40;Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase);Histo-blood group B transferase(B transferase);Histo-blood group A transferase(A transferase);NAGAT;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
    Subcellular Location:
    Golgi apparatus Golgi stack membrane Single-pass type II membrane protein Secreted Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
    Protein Attributes:
    Sequence length:
    354
    Sequence:
    50:
    MAEVLRTLAG | KPKCHALRPM | ILFLIMLVLV | LFGYGVLSPR | SLMPGSLERG | 
    100:
    FCMAVREPDH | LQRVSLPRMV | YPQPKVLTPC | RKDVLVVTPW | LAPIVWEGTF | 
    150:
    NIDILNEQFR | LQNTTIGLTV | FAIKKYVAFL | KLFLETAEKH | FMVGHRVHYY | 
    200:
    VFTDQPAAVP | RVTLGTGRQL | SVLEVRAYKR | WQDVSMRRME | MISDFCERRF | 
    250:
    LSEVDYLVCV | DVDMEFRDHV | GVEILTPLFG | TLHPGFYGSS | REAFTYERRP | 
    300:
    QSQAYIPKDE | GDFYYLGGFF | GGSVQEVQRL | TRACHQAMMV | DQANGIEAVW | 
    350:
    HDESHLNKYL | LRHKPTKVLS | PEYLWDQQLL | GWPAVLRKLR | FTAVPKNHQA | 
    354:
    VRNP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    SMR:
    Pfam:
    UniGene:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Histo-blood group ABO system transferase
    Cat.:
    E8923m
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Histo-blood group ABO system transferase
    Cat.:
    E8923r
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Histo-blood group ABO system transferase
    Cat.:
    E8923h
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human Histo-blood group ABO system transferase
    Cat.:
    U8923r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Histo-blood group ABO system transferase
    Cat.:
    U8923m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Histo-blood group ABO system transferase
    Cat.:
    U8923h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Histo-blood group ABO system transferase
    Cat.:
    P8923Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Histo-blood group ABO system transferase
    Cat.:
    P8923Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Histo-blood group ABO system transferase
    Monoclonal Antibody for Human Histo-blood group ABO system transferase
    Monoclonal Antibody for Human Histo-blood group ABO system transferase
    Monoclonal Antibody for Human Histo-blood group ABO system transferase
    Protein for Human Histo-blood group ABO system transferase
    Protein for Human Histo-blood group ABO system transferase
    Protein for Human Histo-blood group ABO system transferase

    R&D Technical Data
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    s

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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤7.2%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤10.8%

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    Recovery was determined by spiking various levels of BGAT into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    94

    89-101

    Plasma

    95

    91-103

     

     

     

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
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    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of BGAT and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    88-102%

    90-100%

    85-103%

    91-98%

    EDTA plasma(n=5)

    90-101%

    89-101%

    87-102%

    90-102%

    heparin plasma(n=5)

    93-99%

    91-100%

    92-99%

    88-104%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Cloning and characterization of DNA complementary to human UDP-GalNAc: Fuc alpha 1-->2Gal alpha 1-->3GalNAc transferase (histo-blood group A transferase) mRNA."
      Yamamoto F. , Marken J. , Tsuji T. , White T. , Clausen H. , Hakomori S.
      J. Biol. Chem.265:1146-1151(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
    2. 2.
      "Molecular genetic basis of the histo-blood group ABO system."
      Yamamoto F. , Clausen H. , White T. , Marken J. , Hakomori S.
      Nature345:229-233(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT LEU-156
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    5. 5.
      "Human histo-blood group ABO gene locus alleles."
      Yamamoto F.
      Submitted (1999-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];VARIANTS LEU-156; GLY-176; SER-235 AND MET-266
    6. 6.
      "A weak blood group A phenotype caused by a translation-initiator mutation in the ABO gene."
      Seltsam A. , Das Gupta C. , Bade-Doeding C. , Blasczyk R.
      Transfusion46:434-440(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Peripheral blood.
    7. 7.
      "Weak blood group B phenotypes may be caused by variations in the CCAAT-binding factor/NF-Y enhancer region of the ABO gene."
      Seltsam A. , Wagner F.F. , Gruger D. , Gupta C.D. , Bade-Doeding C. , Blasczyk R.
      Transfusion47:2330-2335(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Peripheral blood.
    8. 8.
      "Aberrant intracellular trafficking of a variant B glycosyltransferase."
      Seltsam A. , Gruger D. , Just B. , Figueiredo C. , Gupta C.D. , Deluca D.S. , Blasczyk R.
      Transfusion48:1898-1905(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-230; SER-235; MET-266 AND ALA-268
      tissue: Peripheral blood.
    9. 9.
      SeattleSNPs variation discovery resource
      Submitted (2003-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-35; PHE-36; HIS-63; SER-74; LEU-156; HIS-161; GLY-176; CYS-199; ILE-216; SER-235; MET-266; ALA-268 AND MET-277
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS GLY-176; SER-235; MET-266 AND ALA-268
    11. 11.
      "The nature of diversity and diversification at the ABO locus."
      Seltsam A. , Hallensleben M. , Kollmann A. , Blasczyk R.
      Blood102:3035-3042(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 11-354;VARIANTS SER-74; LEU-156; MET-163; GLY-176; SER-235; MET-266; ALA-268; ARG-268; ARG-288 AND MET-346
    12. 12.
      "Molecular genetic analysis of variant phenotypes of the ABO blood group system."
      Ogasawara K. , Yabe R. , Uchikawa M. , Saitou N. , Bannai M. , Nakata K. , Takenaka M. , Fujisawa K. , Ishikawa Y. , Juji T. , Tokunaga K.
      Blood88:2732-2737(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-354;VARIANTS LEU-156; GLY-176; ARG-214; ILE-216; ASP-223; SER-235; MET-266; ALA-268; MET-277; ASN-291; GLY-352 AND TRP-352
    13. 13.
      "Heterogeneity of the blood group Ax allele: genetic recombination of common alleles can result in the Ax phenotype."
      Olsson M.L. , Chester M.A.
      Transfus. Med.8:231-238(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 81-354
    14. 14.
      "Evolution of the O alleles of the human ABO blood group gene."
      Roubinet F. , Despiau S. , Calafell F. , Jin F. , Bertanpetit J. , Saitou N. , Blancher A.
      Transfusion44:707-715(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 11-354;VARIANTS GLY-176; SER-235; MET-266 AND ALA-268
    15. 15.
      "A novel B Transferase."
      Seltsam A. , Hallensleben M. , Salama A. , Blasczyk R.
      Submitted (2000-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 126-354;VARIANTS GLY-176; SER-235 AND MET-346
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 146-334;VARIANTS MET-266 AND ALA-268
    17. 17.
      "Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid substitutions."
      Yamamoto F. , Hakomori S.
      J. Biol. Chem.265:19257-19262(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    18. 18.
      "The structural basis for specificity in human ABO(H) blood group biosynthesis."
      Patenaude S.I. , Seto N.O.L. , Borisova S.N. , Szpacenko A. , Marcus S.L. , Palcic M.M. , Evans S.V.
      Nat. Struct. Biol.9:685-690(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 64-354;METAL-BINDING;MUTAGENESIS OF GLU-303
    19. 19.
      "A single point mutation reverses the donor specificity of human blood group B-synthesizing galactosyltransferase."
      Marcus S.L. , Polakowski R. , Seto N.O.L. , Leinala E. , Borisova S. , Blancher A. , Roubinet F. , Evans S.V. , Palcic M.M.
      J. Biol. Chem.278:12403-12405(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 64-345 OF MUTANT SER-234 IN COMPLEX WITH GLYCOPROTEIN FUCOSYL-GALACTOSE ANALOG
    20. 20.
      "The influence of an intramolecular hydrogen bond in differential recognition of inhibitory acceptor analogs by human ABO(H) blood group A and B glycosyltransferases."
      Nguyen H.P. , Seto N.O.L. , Cai Y. , Leinala E.K. , Borisova S.N. , Palcic M.M. , Evans S.V.
      J. Biol. Chem.278:49191-49195(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 64-345 IN COMPLEXES WITH UDP; UDP-N-ACETYL-GALACTOSAMINE; UDP-GALACTOSE AND GLYCOPROTEIN FUCOSYL-GALACTOSE ANALOGS
    21. 21.
      "Structural basis for the inactivity of human blood group O2 glycosyltransferase."
      Lee H.J. , Barry C.H. , Borisova S.N. , Seto N.O.L. , Zheng R.B. , Blancher A. , Evans S.V. , Palcic M.M.
      J. Biol. Chem.280:525-529(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.49 ANGSTROMS) OF 64-354 OF MUTANTS SER-74 AND ARG-268 IN COMPLEXES WITH GLYCOPROTEIN FUCOSYL-GALACTOSE ANALOG AND UDP-N-ACETYL-GALACTOSAMINE
    22. 22.
      "Differential recognition of the type I and II H antigen acceptors by the human ABO(H) blood group A and B glycosyltransferases."
      Letts J.A. , Rose N.L. , Fang Y.R. , Barry C.H. , Borisova S.N. , Seto N.O.L. , Palcic M.M. , Evans S.V.
      J. Biol. Chem.281:3625-3632(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.49 ANGSTROMS) OF 64-354 OF HISTO-BLOOD GROUP GROUP A TRANSFERASE AND HISTO-BLOOD GROUP GROUP B TRANSFERASE IN COMPLEXES WITH GLYCOPROTEIN FUCOSYL-GALACTOSE ANALOGS
    23. 23.
      "Structural effects of naturally occurring human blood group B galactosyltransferase mutations adjacent to the DXD motif."
      Persson M. , Letts J.A. , Hosseini-Maaf B. , Borisova S.N. , Palcic M.M. , Evans S.V. , Olsson M.L.
      J. Biol. Chem.282:9564-9570(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.67 ANGSTROMS) OF 64-354 OF MUTANTS ARG-214 AND THR-214;COFACTOR;CHARACTERIZATION OF VARIANT ARG-214;MUTAGENESIS OF MET-214
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