BIN1 ELISA Kit for Human(Homo sapiens) | EIAab.comBIN1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > BIN1(Gene name) > Human

BIN1 (Gene name),

Myc box-dependent-interacting protein 1 (Protein name ), BIN1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

BIN1(AMPHL);

Protein name:

Myc box-dependent-interacting protein 1;

Alternative:

Amphiphysin-like protein;Amphiphysin II;Bridging integrator 1;Box-dependent myc-interacting protein 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer with AMPH. Binds SH3GLB1 (By similarity). Interacts (via SH3 domain) with SYNJ1. Interacts (via SH3 domain) with DNM1. Isoform IIA interacts with CLTC. Isoform IIB does not interact with CLTC. Isoform IIC1 does not interact with CLTC. Isoform IIC2 does not interact with CLTC. Interacts with AP2A2. Interacts with AP2B1. Interacts with MYC (via N-terminal transactivation domain); the interaction requires the integrity of the conserved MYC box regions 1 and 2. Interacts with BIN2. Interacts (SH3 domain) with HCV NS5A.

Function:

May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.

Subcellular Location:

Isoform IIA Cytoplasm

Protein Attributes:

Sequence length:

593

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

593:

PFQNPEEQDE | GWLMGVKESD | WNQHKELEKC | RGVFPENFTE | RVP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

O00499

MIM:

255200

Pfam:

PF03114

UniGene:

Hs.193163

String:

O00499

KEGG:

hsa:274

Uniprot:

O00499

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ELISA Kit for Human Myc box-dependent-interacting protein 1

Cat.:

E8983m

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96T

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ELISA Kit for Human Myc box-dependent-interacting protein 1

Cat.:

E8983r

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Packing:

96T

ELISA Kit for Human Myc box-dependent-interacting protein 1

Cat.:

E8983h

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96T

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CLIA Kit for Human Myc box-dependent-interacting protein 1

Cat.:

U8983h

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Manual:

Looking for manual.

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96T

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CLIA Kit for Human Myc box-dependent-interacting protein 1

Cat.:

U8983m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Myc box-dependent-interacting protein 1

Cat.:

U8983r

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Myc box-dependent-interacting protein 1

Cat.:

P8983Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Myc box-dependent-interacting protein 1

Cat.:

P8983Rb-h

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Packing:

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Polyclonal Antibody for Human Myc box-dependent-interacting protein 1

Monoclonal Antibody for Human Myc box-dependent-interacting protein 1

Protein for Human Myc box-dependent-interacting protein 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Identification and characterization of a nerve terminal-enriched amphiphysin isoform."
Ramjaun A.R. , Micheva K.D. , Bouchelet I. , McPherson P.S.
J. Biol. Chem.272:16700-16706(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IIA)
tissue: Brain.
2.

"Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of Ranvier in brain and around T tubules in skeletal muscle."
Butler M.H. , David C. , Ochoa G.-C. , Freyberg Z. , Daniell L. , Grabs D. , Cremona O. , De Camilli P.
J. Cell Biol.137:1355-1367(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS IIA AND BIN1)
tissue: Brain.
tissue: Skeletal muscle.
3.

"BIN1 is a novel Myc-interacting protein with features of a tumour suppressor."
Sakamuro D. , Elliott K.J. , Wechsler-Reya R. , Prendergast G.C.
Nat. Genet.14:69-76(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BIN1)
tissue: Skeletal muscle.
4.

Sakamuro D. , Elliott K.J. , Wechsler-Reya R. , Prendergast G.C.
Submitted (1998-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO N-TERMINUS
5.

"Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites."
Ramjaun A.R. , McPherson P.S.
J. Neurochem.70:2369-2376(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS IIB; IIC1; IIC2 AND IID);INTERACTION WITH CLTC
tissue: Brain.
6.

"cDNA cloning of a novel amphiphysin isoform and tissue-specific expression of its multiple splice variants."
Tsutsui K. , Maeda Y. , Tsutsui K. , Seki S. , Tokunaga A.
Biochem. Biophys. Res. Commun.236:178-183(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS II2 AND II3)
tissue: Brain.
7.

"Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing."
Wechsler-Reya R.J. , Sakamuro D. , Zhang J. , Duhadaway J. , Prendergast G.C.
J. Biol. Chem.272:31453-31458(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS II3; II3; BIN1-10-13; BIN1-13 AND BIN1+12A)
tissue: Fibroblast.
8.

Zhang J. , Du W. , Wechsler-Reya R.J. , Duhadaway J. , Sakamuro D. , Prendergast G.C.
Submitted (1998-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM II2)
9.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM IIA)
tissue: Brain.
10.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
12.

Yu W. , Gibbs R.A.
Submitted (1998-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 133-593
tissue: Brain.
13.

"A role for the putative tumor suppressor Bin1 in muscle cell differentiation."
Wechsler-Reya R.J. , Elliott K.J. , Prendergast G.C.
Mol. Cell. Biol.18:566-575(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
tissue: Skeletal muscle.
14.

"Bin2, a functionally nonredundant member of the BAR adaptor gene family."
Ge K. , Prendergast G.C.
Genomics67:210-220(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BIN2;TISSUE SPECIFICITY
15.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-303;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
16.

"The SH3 binding motif of HCV NS5A protein interacts with Bin1 and is important for apoptosis and infectivity."
Nanda S.K. , Herion D. , Liang T.J.
Gastroenterology130:794-809(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HCV NS5A
17.

"Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."
Carrascal M. , Ovelleiro D. , Casas V. , Gay M. , Abian J.
J. Proteome Res.7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-307;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: T-cell.
18.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-296; SER-298; SER-303; THR-307; THR-323 AND SER-331;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
19.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
21.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-296; THR-323 AND SER-331;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
22.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
23.

"Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy."
Nicot A.-S. , Toussaint A. , Tosch V. , Kretz C. , Wallgren-Pettersson C. , Iwarsson E. , Kingston H. , Garnier J.-M. , Biancalana V. , Oldfors A. , Mandel J.-L. , Laporte J.
Nat. Genet.39:1134-1139(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CNM2 ASN-35 AND ASN-151;CHARACTERIZATION OF VARIANTS CNM2 ASN-35 AND ASN-151

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