Gene name:
BLNK (BASH;SLP65) ;
Protein name:
B-cell linker protein ;
Alternative:
B-cell adapter containing a Src homology 2 domain protein ;B-cell adapter containing a SH2 domain protein ;Src homology 2 domain-containing leukocyte protein of 65 kDa (SLP-65) ;Cytoplasmic adapter protein ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Associates with PLCG1, VAV1 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with VAV3, PLCG2 and GRB2. Interacts through its SH2 domain with CD79A.
Function:
Functions as a central linker protein that bridges kinases associated with the B-cell receptor (BCR) with a multitude of signaling pathways, regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition (By similarity). Plays an important role in BCR-induced B-cell apoptosis.
Subcellular Location:
Cytoplasm
Cell membrane
BCR activation results in the translocation to membrane fraction.
Protein Attributes:
50:
MDKLNKITVP | ASQKLRQLQK | MVHDIKNNEG | GIMNKIKKLK | VKAPPSVPRR |
100:
DYASESPADE | EEQWSDDFDS | DYENPDEHSD | SEMYVMPAEE | NADDSYEPPP |
150:
VEQETRPVHP | ALPFARGEYI | DNRSSQRHSP | PFSKTLPSKP | SWPSEKARLT |
200:
STLPALTALQ | KPQVPPKPKG | LLEDEADYVV | PVEDNDENYI | HPTESSSPPP |
250:
EKAPMVNRST | KPNSSTPASP | PGTASGRNSG | AWETKSPPPA | APSPLPRAGK |
300:
KPTTPLKTTP | VASQQNASSV | CEEKPIPAER | HRGSSHRQEA | VQSPVFPPAQ |
350:
KQIHQKPIPL | PRFTEGGNPT | VDGPLPSFSS | NSTISEQEAG | VLCKPWYAGA |
400:
CDRKSAEEAL | HRSNKDGSFL | IRKSSGHDSK | QPYTLVVFFN | KRVYNIPVRF |
450:
IEATKQYALG | RKKNGEEYFG | SVAEIIRNHQ | HSPLVLIDSQ | NNTKDSTRLK |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Chicken
ELISA Kit for Human B-cell linker protein
ELISA Kit for Human B-cell linker protein
ELISA Kit for Human B-cell linker protein
ELISA Kit for Human B-cell linker protein
CLIA Kit for Human B-cell linker protein
CLIA Kit for Human B-cell linker protein
CLIA Kit for Human B-cell linker protein
CLIA Kit for Human B-cell linker protein
Polyclonal Antibody for Human B-cell linker protein
Polyclonal Antibody for Human B-cell linker protein
Polyclonal Antibody for Human B-cell linker protein
Polyclonal Antibody for Human B-cell linker protein
Monoclonal Antibody for Human B-cell linker protein
Monoclonal Antibody for Human B-cell linker protein
Monoclonal Antibody for Human B-cell linker protein
Monoclonal Antibody for Human B-cell linker protein
Protein for Human B-cell linker protein
Protein for Human B-cell linker protein
Protein for Human B-cell linker protein
Protein for Human B-cell linker protein
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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tissue :
B-cell .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-72; TYR-84; TYR-96; TYR-178 AND TYR-189 BY SYK;MUTAGENESIS OF TYR-72; TYR-84 AND TYR-96
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SCIMP