BMP4 ELISA Kit for Human(Homo sapiens) | EIAab.comBMP4 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > BMP4(Gene name) > Human

BMP4 (Gene name),

Bone morphogenetic protein 4 (Protein name ), BMP4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

BMP4(BMP2B;DVR4);

Protein name:

Bone morphogenetic protein 4(BMP-4);

Alternative:

Bone morphogenetic protein 2B(BMP-2B);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer; disulfide-linked (By similarity). Interacts with GREM2 (By similarity) and SOSTDC1. Part of a complex consisting of TWSG1 and CHRD.

Function:

Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.

Subcellular Location:

Secreted extracellular space extracellular matrix

Protein Attributes:

Sequence length:

408

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

408:

VVEGCGCR

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

112262

Pfam:

PF00019

KEGG:

hsa:652

STRING:

9606.ENSP00000245451

UniGene:

Hs.68879

String:

P12644

SMR:

P12644

Uniprot:

P12644

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ELISA Kit for Human BMP-4

Cat.:

E0014h

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96T

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ELISA Kit for Human BMP-4

Cat.:

E0014m

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96T

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ELISA Kit for Human BMP-4

Cat.:

E0014r

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96T

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ELISA Kit for Human BMP-4

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ELISA Kit for Human BMP-4

Cat.:

E0014b

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96T

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ELISA Kit for Human BMP-4

Cat.:

E0014c

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96T

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CLIA Kit for Human BMP-4

Cat.:

U0014c

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Packing:

96T

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CLIA Kit for Human BMP-4

Cat.:

U0014b

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96T

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CLIA Kit for Human BMP-4

MSDS:

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CLIA Kit for Human BMP-4

Cat.:

U0014r

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Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

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CLIA Kit for Human BMP-4

Cat.:

U0014m

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Please sign in first.

Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human BMP-4

Cat.:

U0014h

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96T

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Polyclonal Antibody for Human BMP-4

Cat.:

P0014Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human BMP-4

Cat.:

P0014Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human BMP-4

Cat.:

P0014Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human BMP-4

Protein for Human BMP-4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤4.4%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.9%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

Recovery was determined by spiking various levels of BMP4 into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	99	96-102
Plasma	98	94-100

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of BMP4 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	96-100%	98-101%	94-99%	96-100%
EDTA plasma(n=5)	95-99%	98-103%	100-103%	102-106%
heparin plasma(n=5)	96-101%	98-100%	95-103%	101-105%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Novel regulators of bone formation: molecular clones and activities."
Wozney J.M. , Rosen V. , Celeste A.J. , Mitsock L.M. , Whitters M.J. , Kriz R.W. , Hewick R.M. , Wang E.A.
Science242:1528-1534(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"The human bone morphogenetic protein 4 (BMP-4) gene: molecular structure and transcriptional regulation."
Shore E.M. , Xu M. , Shah P.B. , Janoff H.B. , Hahn G.V. , Deardorff M.A. , Sovinsky L. , Spinner N.B. , Zasloff M.A. , Wozney J.M. , Kaplan F.S.
Calcif. Tissue Int.63:221-229(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ALA-152
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ALA-152
tissue: Duodenum.
4.

"Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library."
Oida S. , Iimura T. , Maruoka Y. , Takeda K. , Sasaki S.
DNA Seq.5:273-275(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-408
tissue: Placenta.
5.

"USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney."
Yanagita M. , Oka M. , Watabe T. , Iguchi H. , Niida A. , Takahashi S. , Akiyama T. , Miyazono K. , Yanagisawa M. , Sakurai T.
Biochem. Biophys. Res. Commun.316:490-500(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SOSTDC1
6.

"Evaluation of BMP4 and its specific inhibitor NOG as candidates in human neural tube defects (NTDs)."
Felder B. , Stegmann K. , Schultealbert A. , Geller F. , Strehl E. , Ermert A. , Koch M.C.
Eur. J. Hum. Genet.10:753-756(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYS-91; ALA-152; ALA-225; TRP-226 AND THR-367
7.

"Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathways."
Bakrania P. , Efthymiou M. , Klein J.C. , Salt A. , Bunyan D.J. , Wyatt A. , Ponting C.P. , Martin A. , Williams S. , Lindley V. , Gilmore J. , Restori M. , Robson A.G. , Neveu M.M. , Holder G.E. , Collin J.R.O. , Robinson D.O. , Farndon P. , more...
Am. J. Hum. Genet.82d:304-319(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MCOPS6 GLY-93
8.

"SIX2 and BMP4 mutations associate with anomalous kidney development."
Weber S. , Taylor J.C. , Winyard P. , Baker K.F. , Sullivan-Brown J. , Schild R. , Knueppel T. , Zurowska A.M. , Caldas-Alfonso A. , Litwin M. , Emre S. , Ghiggeri G.M. , Bakkaloglu A. , Mehls O. , Antignac C. , Schaefer F. , Burdine R.D.
J. Am. Soc. Nephrol.19:891-903(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYS-91; SER-116 AND LYS-150
9.

"Mutations in BMP4 are associated with subepithelial, microform, and overt cleft lip."
Suzuki S. , Marazita M.L. , Cooper M.E. , Miwa N. , Hing A. , Jugessur A. , Natsume N. , Shimozato K. , Ohbayashi N. , Suzuki Y. , Niimi T. , Minami K. , Yamamoto M. , Altannamar T.J. , Erkhembaatar T. , Furukawa H. , Daack-Hirsch S. , L'heureux J. , more...
Am. J. Hum. Genet.84:406-411(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS OFC11 CYS-91; GLN-162; HIS-287 AND VAL-346;VARIANTS ALA-102; ALA-152 AND ALA-168

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