BMPR2 ELISA Kit for Human(Homo sapiens) | EIAab.comBMPR2 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > BMPR2(Gene name) > Human

BMPR2 (Gene name),

Bone morphogenetic protein receptor type-2 (Protein name ), BMPR2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

BMPR2(PPH1);

Protein name:

Bone morphogenetic protein receptor type-2(BMP type-2 receptor;BMPR-2);

Alternative:

Bone morphogenetic protein receptor type II(BMP type II receptor;BMPR-II);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

1038

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1038:

NNNGSNRAVH | SKSSTAVYLA | EGGTATTMVS | KDIGMNCL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.471119

MIM:

178600

String:

Q13873

STRING:

9606.ENSP00000363708

KEGG:

hsa:659

SMR:

Q13873

Pfam:

PF01064

Uniprot:

Q13873

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ELISA Kit for Human BMP type-2 receptor

Cat.:

E0016h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human BMP type-2 receptor

Cat.:

E0016m

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Packing:

96T

CLIA Kit for Human BMP type-2 receptor

Cat.:

U0016m

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MSDS:

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Packing:

96T

CLIA Kit for Human BMP type-2 receptor

Cat.:

U0016h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human BMP type-2 receptor

Cat.:

P0016Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human BMP type-2 receptor

Cat.:

P0016Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human BMP type-2 receptor

Protein for Human BMP type-2 receptor

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs."
Liu F. , Ventura F. , Doody J. , Massague J.
Mol. Cell. Biol.15:3479-3486(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);ALTERNATIVE SPLICING
tissue: Kidney.
2.

"Cloning and characterization of a human type II receptor for bone morphogenetic proteins."
Rosenzweig B.L. , Imamura T. , Okadome T. , Cox G.N. , Yamashita H. , ten Dijke P. , Heldin C. , Miyazono K.
Proc. Natl. Acad. Sci. U.S.A.92:7632-7636(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Substantia nigra.
3.

"Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors."
Nohno T. , Ishikawa T. , Saito T. , Hosokawa K. , Noji S. , Wosing D.H. , Rosenbaum J.S.
J. Biol. Chem.270:22522-22526(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Skin fibroblast.
4.

"Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor."
Kawabata M. , Chytil A. , Moses H.L.
J. Biol. Chem.270:5625-5630(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
5.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Skin.
8.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-586;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
9.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-379;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.

"Crystal structure of the BMPR2 kinase domain."
Structural genomics consortium (SGC)
Submitted (2009-02) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 189-517 IN COMPLEX WITH ADP
11.

"Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene."
Deng Z. , Morse J.H. , Slager S.L. , Cuervo N. , Moore K.J. , Venetos G. , Kalachikov S. , Cayanis E. , Fischer S.G. , Barst R.J. , Hodge S.E. , Knowles J.A.
Am. J. Hum. Genet.67:737-744(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PPH1 GLN-491 AND TRP-491
12.

"Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family."
Thomson J.R. , Machado R.D. , Pauciulo M.W. , Morgan N.V. , Humbert M. , Elliott G.C. , Ward K. , Yacoub M. , Mikhail G. , Rogers P. , Newman J.H. , Wheeler L. , Higenbottam T. , Gibbs J.S.R. , Egan J. , Crozier A. , Peacock A. , Allcock R. , more...
J. Med. Genet.37:741-745(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PPH1 TYR-60; TYR-117 AND ARG-483
13.

"Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension."
Lane K.B. , Machado R.D. , Pauciulo M.W. , Thomson J.R. , Phillips J.A. III , Loyd J.E. , Nichols W.C. , Trembath R.C. , Aldred M. , Brannon C.A. , Conneally P.M. , Foroud T. , Fretwell N. , Gaddipati R. , Koller D. , Loyd E.J. , Morgan N.V. , Newman J.H. , more...
Nat. Genet.26:81-84(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PPH1 TRP-118; TYR-347 AND GLY-485
14.

"BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension."
Machado R.D. , Pauciulo M.W. , Thomson J.R. , Lane K.B. , Morgan N.V. , Wheeler L. , Phillips J.A. III , Newman J.H. , Williams D. , Galie N. , Manes A. , McNeil K. , Yacoub M. , Mikhail G. , Rogers P. , Corris P. , Humbert M. , Donnai D. , more...
Am. J. Hum. Genet.68:92-102(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PPH1 ARG-123; SER-123; ARG-420 AND THR-512;VARIANT ASP-224;CHARACTERIZATION OF VARIANT PPH1 GLY-485
15.

"BMPR2 germline mutations in pulmonary hypertension associated with fenfluramine derivatives."
Humbert M. , Deng Z. , Simonneau G. , Barst R.J. , Sitbon O. , Wolf M. , Cuervo N. , Moore K.J. , Hodge S.E. , Knowles J.A. , Morse J.H.
Eur. Respir. J.20:518-523(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PPH1 HIS-82; ASP-182 AND ARG-483
16.

"Pulmonary veno-occlusive disease caused by an inherited mutation in bone morphogenetic protein receptor II."
Runo J.R. , Vnencak-Jones C.L. , Prince M. , Loyd J.E. , Wheeler L. , Robbins I.M. , Lane K.B. , Newman J.H. , Johnson J. , Nichols W.C. , Phillips J.A. III
Am. J. Respir. Crit. Care Med.167:889-894(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN PVOD1
17.

"BMPR2 mutations have short lifetime expectancy in primary pulmonary hypertension."
Sankelo M. , Flanagan J.A. , Machado R. , Harrison R. , Rudarakanchana N. , Morrell N. , Dixon M. , Halme M. , Puolijoki H. , Kere J. , Elomaa O. , Kupari M. , Raeisaenen-Sokolowski A. , Trembath R.C. , Laitinen T.
Hum. Mutat.26:119-124(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PPH1 PRO-899;CHARACTERIZATION OF VARIANT PPH1 PRO-899
18.

"Mutations of the TGF-beta type II receptor BMPR2 in pulmonary arterial hypertension."
Machado R.D. , Aldred M.A. , James V. , Harrison R.E. , Patel B. , Schwalbe E.C. , Gruenig E. , Janssen B. , Koehler R. , Seeger W. , Eickelberg O. , Olschewski H. , Elliott C.G. , Glissmeyer E. , Carlquist J. , Kim M. , Torbicki A. , Fijalkowska A. , more...
Hum. Mutat.27:121-132(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN PVOD1
19.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ASN-775

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