BMPR1A ELISA Kit for Human(Homo sapiens) | EIAab.comBMPR1A ELISA Kit for Human(Homo sapiens)

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BMPR1A (Gene name),

Bone morphogenetic protein receptor type-1A (Protein name ), BMR1A_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

BMPR1A(ACVRLK3;ALK3);

Protein name:

Bone morphogenetic protein receptor type-1A(BMP type-1A receptor;BMPR-1A);

Alternative:

Serine/threonine-protein kinase receptor R5(SKR5);Activin receptor-like kinase 3(ALK-3);

CD:

CD292;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

532

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

532:

SECWAHNPAS | RLTALRIKKT | LAKMVESQDV | KI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P36894

UniGene:

Hs.524477

KEGG:

hsa:657

SMR:

P36894

MIM:

174900

STRING:

9606.ENSP00000224764

MIM:

158350

Pfam:

PF01064

Uniprot:

P36894

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ELISA Kit for Human BMP type-1A receptor

Cat.:

E0015h

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96T

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ELISA Kit for Human BMP type-1A receptor

Cat.:

E0015r

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96T

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ELISA Kit for Human BMP type-1A receptor

Cat.:

E0015m

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MSDS:

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Packing:

96T

CLIA Kit for Human BMP type-1A receptor

Cat.:

U0015r

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Manual:

Looking for manual.

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Packing:

96T

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CLIA Kit for Human BMP type-1A receptor

Cat.:

U0015h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human BMP type-1A receptor

Cat.:

U0015m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human BMP type-1A receptor

Cat.:

P0015Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human BMP type-1A receptor

Cat.:

P0015Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human BMP type-1A receptor

Cat.:

P0015Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human BMP type-1A receptor

Protein for Human BMP type-1A receptor

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity."
ten Dijke P. , Ichijo H. , Franzen P. , Schulz P. , Saras J. , Toyoshima H. , Heldin C.-H. , Miyazono K.
Oncogene8:2879-2887(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT THR-2
tissue: Placenta.
2.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT THR-2
tissue: Placenta.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Testis.
4.

"Structure of the Alk1 extracellular domain and characterization of its bone morphogenetic protein (BMP) binding properties."
Mahlawat P. , Ilangovan U. , Biswas T. , Sun L.Z. , Hinck A.P.
Biochemistry51:6328-6341(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BMP2;MUTAGENESIS OF 107-ASP--GLN-109
5.

"Crystal structure of the BMP-2-BRIA ectodomain complex."
Kirsch T. , Sebald W. , Dreyer M.K.
Nat. Struct. Biol.7:492-496(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 55-143 IN COMPLEX WITH BMP-2
6.

"Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis."
Howe J.R. , Bair J.L. , Sayed M.G. , Anderson M.E. , Mitros F.A. , Petersen G.M. , Velculescu V.E. , Traverso G. , Vogelstein B.
Nat. Genet.28:184-187(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE
7.

"Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes."
Zhou X.-P. , Woodford-Richens K. , Lehtonen R. , Kurose K. , Aldred M. , Hampel H. , Launonen V. , Virta S. , Pilarski R. , Salovaara R. , Bodmer W.F. , Conrad B.A. , Dunlop M. , Hodgson S.V. , Iwama T. , Jaervinen H. , Kellokumpu I. , Kim J.C. , more...
Am. J. Hum. Genet.69:704-711(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS JPS ARG-124; ASP-338 AND TYR-376
8.

"Germline SMAD4 or BMPR1A mutations and phenotype of juvenile polyposis."
Sayed M.G. , Ahmed A.F. , Ringold J.R. , Anderson M.E. , Bair J.L. , Mitros F.A. , Lynch H.T. , Tinley S.T. , Petersen G.M. , Giardiello F.M. , Vogelstein B. , Howe J.R.
Ann. Surg. Oncol.9:901-906(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS JPS ASP-62; TYR-82 AND CYS-443
9.

"Juvenile polyposis: massive gastric polyposis is more common in MADH4 mutation carriers than in BMPR1A mutation carriers."
Friedl W. , Uhlhaas S. , Schulmann K. , Stolte M. , Loff S. , Back W. , Mangold E. , Stern M. , Knaebel H.P. , Sutter C. , Weber R.G. , Pistorius S. , Burger B. , Propping P.
Hum. Genet.111:108-111(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT JPS ARG-130
10.

"Identification of a novel BMPR1A germline mutation in a Korean juvenile polyposis patient without SMAD4 mutation."
Kim I.J. , Park J.H. , Kang H.C. , Kim K.H. , Kim J.H. , Ku J.L. , Kang S.B. , Park S.Y. , Lee J.S. , Park J.G.
Clin. Genet.63:126-130(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT JPS THR-470
11.

"Contiguous gene deletion within chromosome arm 10q is associated with juvenile polyposis of infancy, reflecting cooperation between the BMPR1A and PTEN tumor-suppressor genes."
Delnatte C. , Sanlaville D. , Mougenot J.-F. , Vermeesch J.-R. , Houdayer C. , Blois M.-C. , Genevieve D. , Goulet O. , Fryns J.-P. , Jaubert F. , Vekemans M. , Lyonnet S. , Romana S. , Eng C. , Stoppa-Lyonnet D.
Am. J. Hum. Genet.78:1066-1074(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN JUVENILE POLYPOSIS OF INFANCY
12.

"Mapping of hereditary mixed polyposis syndrome (HMPS) to chromosome 10q23 by genomewide high-density single nucleotide polymorphism (SNP) scan and identification of BMPR1A loss of function."
Cao X. , Eu K.W. , Kumarasinghe M.P. , Li H.H. , Loi C. , Cheah P.Y.
J. Med. Genet.43:E13-E13(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN HEREDITARY MIXED POLYPOSIS SYNDROME 2
13.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-2; TYR-58; CYS-443; MET-450 AND GLN-486

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